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    SRFBP1 serum response factor binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 153443, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SRFBP1provided by HGNC
    Official Full Name
    serum response factor binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:26333
    See related
    Ensembl:ENSG00000151304 MIM:610479; AllianceGenome:HGNC:26333
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P49; Rlb1; BUD22; STRAP; p49/STRAP
    Summary
    Enables RNA binding activity. Predicted to be involved in maturation of SSU-rRNA. Predicted to be located in perinuclear region of cytoplasm. Predicted to be part of 90S preribosome. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 4.8), fat (RPKM 4.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SRFBP1 in Genome Data Viewer
    Location:
    5q23.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (121961975..122078935)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (122478734..122592980)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (121297670..121364328)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379149 Neighboring gene uncharacterized LOC105379148 Neighboring gene ferritin mitochondrial Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:121297323-121297861 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:121412305-121412822 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:121412823-121413340 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:121434535-121435734 Neighboring gene lysyl oxidase Neighboring gene Sharpr-MPRA regulatory region 13182 Neighboring gene ZNF474 antisense RNA 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:121464631-121465830 Neighboring gene zinc finger protein 474 Neighboring gene zinc finger protein 475

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Interaction of Hsp70 with p49/STRAP, a serum response factor binding protein. Lin JL, et al. Biochem Biophys Res Commun, 2009 Nov 27. PMID 19751705
    2. Quantitative Proteomics Identifies Serum Response Factor Binding Protein 1 as a Host Factor for Hepatitis C Virus Entry. Gerold G, et al. Cell Rep, 2015 Aug 4. PMID 26212323, Free PMC Article
    3. Identification of a subunit of NADH-dehydrogenase as a p49/STRAP-binding protein. Zhang X, et al. BMC Cell Biol, 2008 Jan 29. PMID 18230186, Free PMC Article
    4. Does p49/STRAP, a SRF-binding protein (SRFBP1), modulate cardiac mitochondrial function in aging? Zhang X, et al. Exp Gerontol, 2016 Sep. PMID 27337995, Free PMC Article
    5. Heterogeneity of ternary complex factors in HeLa cell nuclear extracts. Pingoud V, et al. J Biol Chem, 1994 Sep 16. PMID 8083237

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. P49/STRAP expression was increased in the old versus young adult mouse hearts and also increased with advancing population doubling levels in cultured human umbilical vein endothelial cells. The increased expression of p49/STRAP in late life may alter the status of histone acetylation and impact mitochondrial dynamics and thereby reduce mitochondrial function and cardiac performance during mammalian senescence.
      Title: Does p49/STRAP, a SRF-binding protein (SRFBP1), modulate cardiac mitochondrial function in aging?
    2. SRFBP1 is an HCV-specific, pan-genotypic host entry factor.
      Title: Quantitative Proteomics Identifies Serum Response Factor Binding Protein 1 as a Host Factor for Hepatitis C Virus Entry.
    3. p49/STRAP can be considered a bona fide co-chaperone of Hsp70.
      Title: Interaction of Hsp70 with p49/STRAP, a serum response factor binding protein.
    4. p49/STRAP plays a role in the regulation of intracellular processes such as cardiac cellular metabolism, gene expression, and possibly aging.
      Title: Identification of a subunit of NADH-dehydrogenase as a p49/STRAP-binding protein.
    5. p49/STRAP may be an important SRF cofactor in the transcriptional regulation of mammalian cardiac muscle genes throughout the life span
      Title: Identification of a novel serum response factor cofactor in cardiac gene regulation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ25286

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of 90S preribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serum response factor-binding protein 1
    Names
    BUD22 homolog
    SRF-dependent transcription regulation-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152546.3 → NP_689759.2  serum response factor-binding protein 1

      See identical proteins and their annotated locations for NP_689759.2

      Status: VALIDATED

      Source sequence(s)
      AC010255, AK058015, BC017102, BG193119
      Consensus CDS
      CCDS43354.1
      UniProtKB/Swiss-Prot
      Q5QFI2, Q8NEF9, Q96AH4, Q96DK2
      Related
      ENSP00000341324.4, ENST00000339397.5
      Conserved Domains (2) summary
      PTZ00108
      Location:37 → 285
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam09073
      Location:355 → 428
      BUD22

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      121961975..122078935
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017009111.3 → XP_016864600.2  serum response factor-binding protein 1 isoform X1

      Conserved Domains (1) summary
      cl25574
      Location:37 → 285
      TOP2c; TopoisomeraseII

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      122478734..122592980
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351798.1 → XP_054207773.1  serum response factor-binding protein 1 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NEF9.1 GenPept UniProtKB/Swiss-Prot:Q8NEF9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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