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    RALA RAS like proto-oncogene A [ Homo sapiens (human) ]

    Gene ID: 5898, updated on 9-Dec-2024

    Summary

    Official Symbol
    RALAprovided by HGNC
    Official Full Name
    RAS like proto-oncogene Aprovided by HGNC
    Primary source
    HGNC:HGNC:9839
    See related
    Ensembl:ENSG00000006451 MIM:179550; AllianceGenome:HGNC:9839
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RAL; HINCONS
    Summary
    The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in esophagus (RPKM 22.0), lung (RPKM 20.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RALA in Genome Data Viewer
    Location:
    7p14.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (39623572..39708120)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (39781130..39865684)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (39663171..39747719)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene YAE1 maturation factor of ABCE1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18111 Neighboring gene uncharacterized LOC107986785 Neighboring gene akirin 1 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:39663047-39663894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25879 Neighboring gene Sharpr-MPRA regulatory region 6412 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25880 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:39761893-39762394 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:39762968-39763530 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:39763531-39764091 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25881 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25882 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:39772987-39774186 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:39774391-39775162 Neighboring gene long intergenic non-protein coding RNA 265 Neighboring gene NANOG hESC enhancer GRCh37_chr7:39789308-39790145 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:39793752-39794419 Neighboring gene RNA, U6 small nuclear 719, pseudogene Neighboring gene capicua transcriptional repressor pseudogene 22

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of v-ral simian leukemia viral oncogene homolog A (RALA) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC48949

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables Edg-2 lysophosphatidic acid receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GDP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables myosin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chemotaxis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in establishment of protein localization to mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in membrane raft localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neural tube closure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of filopodium assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of mitochondrial fission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in receptor internalization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of exocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Flemming body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    colocalizes_with endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in focal adhesion HDA PubMed 
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ras-related protein Ral-A
    Names
    RALA Ras like proto-oncogene A
    RAS-like protein A
    Ras family small GTP binding protein RALA
    ras related GTP binding protein A
    v-ral simian leukemia viral oncogene homolog A (ras related)
    NP_005393.2
    XP_047276637.1
    XP_047276638.1
    XP_054214726.1
    XP_054214727.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005402.4NP_005393.2  ras-related protein Ral-A precursor

      See identical proteins and their annotated locations for NP_005393.2

      Status: REVIEWED

      Source sequence(s)
      BC039858, DC313757
      Consensus CDS
      CCDS5460.1
      UniProtKB/Swiss-Prot
      A4D1W3, P11233
      Related
      ENSP00000005257.2, ENST00000005257.7
      Conserved Domains (1) summary
      cd04139
      Location:15177
      RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      39623572..39708120
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420682.1XP_047276638.1  ras-related protein Ral-A isoform X1

      UniProtKB/Swiss-Prot
      A4D1W3, P11233
    2. XM_047420681.1XP_047276637.1  ras-related protein Ral-A isoform X1

      UniProtKB/Swiss-Prot
      A4D1W3, P11233

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      39781130..39865684
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358752.1XP_054214727.1  ras-related protein Ral-A isoform X1

      UniProtKB/Swiss-Prot
      A4D1W3, P11233
    2. XM_054358751.1XP_054214726.1  ras-related protein Ral-A isoform X1

      UniProtKB/Swiss-Prot
      A4D1W3, P11233