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    FER1L6 fer-1 like family member 6 [ Homo sapiens (human) ]

    Gene ID: 654463, updated on 9-Dec-2024

    Summary

    Official Symbol
    FER1L6provided by HGNC
    Official Full Name
    fer-1 like family member 6provided by HGNC
    Primary source
    HGNC:HGNC:28065
    See related
    Ensembl:ENSG00000214814 MIM:620884; AllianceGenome:HGNC:28065
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C8ORFK23
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in positive regulation of gene expression. Predicted to act upstream of or within response to bacterium. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in stomach (RPKM 17.6), colon (RPKM 3.5) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FER1L6 in Genome Data Viewer
    Location:
    8q24.13
    Exon count:
    48
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (123851987..124120061)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (124984227..125252427)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (124864227..125132302)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375739 Neighboring gene annexin A13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19505 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19506 Neighboring gene family with sequence similarity 91 member A1 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:124863791-124863939 Neighboring gene uncharacterized LOC124902014 Neighboring gene Sharpr-MPRA regulatory region 15371 Neighboring gene FER1L6 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 12119 Neighboring gene FER1L6 antisense RNA 2 Neighboring gene neuropilin and tolloid like 2 pseudogene Neighboring gene ARF GTPase 1 pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    fer-1-like protein 6
    Names
    fer-1-like 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039112.2NP_001034201.2  fer-1-like protein 6

      See identical proteins and their annotated locations for NP_001034201.2

      Status: VALIDATED

      Source sequence(s)
      AB196633, AC011134, AC100871, DV080599, DW010047
      Consensus CDS
      CCDS43767.1
      UniProtKB/Swiss-Prot
      Q2WGJ9
      Related
      ENSP00000428280.1, ENST00000522917.5
      Conserved Domains (8) summary
      cd04011
      Location:80189
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:826959
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04018
      Location:244395
      C2C_Ferlin; C2 domain third repeat in Ferlin
      cd04037
      Location:13571480
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08374
      Location:15971730
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      pfam08150
      Location:713784
      FerB; FerB (NUC096) domain
      pfam08151
      Location:187236
      FerI; FerI (NUC094) domain
      pfam16165
      Location:17411850
      Ferlin_C; Ferlin C-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      123851987..124120061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011517231.3XP_011515533.1  fer-1-like protein 6 isoform X1

      Conserved Domains (8) summary
      cd04011
      Location:103212
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:849982
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04018
      Location:267418
      C2C_Ferlin; C2 domain third repeat in Ferlin
      cd04037
      Location:13801503
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08374
      Location:16201753
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      pfam08150
      Location:736807
      FerB; FerB (NUC096) domain
      pfam08151
      Location:210259
      FerI; FerI (NUC094) domain
      pfam16165
      Location:17641873
      Ferlin_C; Ferlin C-terminus
    2. XM_006716618.4XP_006716681.1  fer-1-like protein 6 isoform X2

      Conserved Domains (8) summary
      cd04011
      Location:90199
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:836969
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04018
      Location:254405
      C2C_Ferlin; C2 domain third repeat in Ferlin
      cd04037
      Location:13671490
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08374
      Location:16071740
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      pfam08150
      Location:723794
      FerB; FerB (NUC096) domain
      pfam08151
      Location:197246
      FerI; FerI (NUC094) domain
      pfam16165
      Location:17511860
      Ferlin_C; Ferlin C-terminus
    3. XM_011517235.4XP_011515537.1  fer-1-like protein 6 isoform X4

      Conserved Domains (7) summary
      cd04011
      Location:103212
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:849982
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04018
      Location:267418
      C2C_Ferlin; C2 domain third repeat in Ferlin
      pfam05103
      Location:628734
      DivIVA; DivIVA protein
      pfam08150
      Location:736807
      FerB; FerB (NUC096) domain
      pfam08151
      Location:210259
      FerI; FerI (NUC094) domain
      cl14603
      Location:13801437
      C2; C2 domain
    4. XM_011517232.4XP_011515534.1  fer-1-like protein 6 isoform X3

      See identical proteins and their annotated locations for XP_011515534.1

      UniProtKB/Swiss-Prot
      Q2WGJ9
      Conserved Domains (8) summary
      cd04011
      Location:80189
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:826959
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04018
      Location:244395
      C2C_Ferlin; C2 domain third repeat in Ferlin
      cd04037
      Location:13571480
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08374
      Location:15971730
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      pfam08150
      Location:713784
      FerB; FerB (NUC096) domain
      pfam08151
      Location:187236
      FerI; FerI (NUC094) domain
      pfam16165
      Location:17411850
      Ferlin_C; Ferlin C-terminus
    5. XM_011517233.4XP_011515535.1  fer-1-like protein 6 isoform X3

      See identical proteins and their annotated locations for XP_011515535.1

      UniProtKB/Swiss-Prot
      Q2WGJ9
      Conserved Domains (8) summary
      cd04011
      Location:80189
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:826959
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04018
      Location:244395
      C2C_Ferlin; C2 domain third repeat in Ferlin
      cd04037
      Location:13571480
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08374
      Location:15971730
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      pfam08150
      Location:713784
      FerB; FerB (NUC096) domain
      pfam08151
      Location:187236
      FerI; FerI (NUC094) domain
      pfam16165
      Location:17411850
      Ferlin_C; Ferlin C-terminus
    6. XM_047422118.1XP_047278074.1  fer-1-like protein 6 isoform X6

    7. XM_011517236.3XP_011515538.1  fer-1-like protein 6 isoform X5

      Conserved Domains (4) summary
      cd04017
      Location:499
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04037
      Location:497620
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08374
      Location:737870
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      pfam16165
      Location:881990
      Ferlin_C; Ferlin C-terminus
    8. XM_047422117.1XP_047278073.1  fer-1-like protein 6 isoform X6

    RNA

    1. XR_928347.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      124984227..125252427
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361033.1XP_054217008.1  fer-1-like protein 6 isoform X1

    2. XM_054361037.1XP_054217012.1  fer-1-like protein 6 isoform X4

    3. XM_054361034.1XP_054217009.1  fer-1-like protein 6 isoform X2

    4. XM_054361035.1XP_054217010.1  fer-1-like protein 6 isoform X3

    5. XM_054361036.1XP_054217011.1  fer-1-like protein 6 isoform X3

    6. XM_054361040.1XP_054217015.1  fer-1-like protein 6 isoform X6

    7. XM_054361038.1XP_054217013.1  fer-1-like protein 6 isoform X5

    8. XM_054361039.1XP_054217014.1  fer-1-like protein 6 isoform X6

    RNA

    1. XR_008487872.1 RNA Sequence