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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_007159.3 RefSeqGene
- Range
-
4981..181615
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_000084.5 → NP_000075.1 H(+)/Cl(-) exchange transporter 5 isoform b
See identical proteins and their annotated locations for NP_000075.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (3, also known as type 3) lacks several 5' exons but has an alternate 5' exon, and it thus differs in the 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (b) has a shorter N-terminus, compared to isoform a.
- Source sequence(s)
-
AC231645, AK025562, AK290940, BC051691, BX950885
- Consensus CDS
-
CCDS14328.1
- UniProtKB/TrEMBL
-
A8K4H5
- Related
- ENSP00000365276.3, ENST00000376108.7
- Conserved Domains (2) summary
-
- cd03684
Location:72 → 570
- ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...
- cd04591
Location:595 → 731
- CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
-
NM_001127898.4 → NP_001121370.1 H(+)/Cl(-) exchange transporter 5 isoform a
See identical proteins and their annotated locations for NP_001121370.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2, also known as type 1) uses an alternate splice site in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
- Source sequence(s)
-
AC231645, AC236430, AK025562, AK056560, BC051691, DA652242
- Consensus CDS
-
CCDS48115.1
- UniProtKB/Swiss-Prot
- A1L475, B3KPN6, P51795, Q5JQD5, Q7RTN8
- UniProtKB/TrEMBL
-
A8K4H5
- Related
- ENSP00000365259.3, ENST00000376091.8
- Conserved Domains (2) summary
-
- cd03684
Location:142 → 640
- ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...
- cd04591
Location:651 → 801
- CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria
-
NM_001127899.4 → NP_001121371.1 H(+)/Cl(-) exchange transporter 5 isoform a
See identical proteins and their annotated locations for NP_001121371.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1, also known as type 2) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 2 encode the same isoform.
- Source sequence(s)
-
AC231645, AC236430, AK025562, AK092049, BC051691, BK000969, DA737534
- Consensus CDS
-
CCDS48115.1
- UniProtKB/Swiss-Prot
- A1L475, B3KPN6, P51795, Q5JQD5, Q7RTN8
- UniProtKB/TrEMBL
-
A8K4H5
- Related
- ENSP00000365256.3, ENST00000376088.7
- Conserved Domains (2) summary
-
- cd03684
Location:142 → 640
- ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...
- cd04591
Location:651 → 801
- CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria
-
NM_001272102.2 → NP_001259031.1 H(+)/Cl(-) exchange transporter 5 isoform c
See identical proteins and their annotated locations for NP_001259031.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR, it lacks several 3' exons but has an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c) has a distinct and shorter C-terminus, compared to isoform a.
- Source sequence(s)
-
AC236430, AK092049, BF513571
- Consensus CDS
-
CCDS69763.1
- UniProtKB/TrEMBL
-
V9GYG7
- Related
- ENSP00000476732.1, ENST00000482218.2
-
NM_001282163.2 → NP_001269092.1 H(+)/Cl(-) exchange transporter 5 isoform d
See identical proteins and their annotated locations for NP_001269092.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (4, also known as type 4) lacks several 5' exons but has an alternate 5' exon, and it thus differs in the 5' UTR and uses an alternate start codon, compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus, compared to isoform a.
- Source sequence(s)
-
AC231645, AK025562, BC051691, X91906
- UniProtKB/TrEMBL
-
A8K4H5
- Conserved Domains (4) summary
-
- COG0517
Location:603 → 749
- CBS; CBS domain [Signal transduction mechanisms]
- cd03684
Location:92 → 590
- ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...
- cd04591
Location:615 → 751
- CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
- pfam00654
Location:169 → 570
- Voltage_CLC; Voltage gated chloride channel
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000023.11 Reference GRCh38.p14 Primary Assembly
- Range
-
49922596..50099230
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_017029258.2 → XP_016884747.1 H(+)/Cl(-) exchange transporter 5 isoform X1
- UniProtKB/TrEMBL
-
A8K4H5
- Conserved Domains (2) summary
-
- cd03684
Location:146 → 644
- ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...
- cd04591
Location:655 → 805
- CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria
-
XM_017029257.2 → XP_016884746.1 H(+)/Cl(-) exchange transporter 5 isoform X1
- UniProtKB/TrEMBL
-
A8K4H5
- Conserved Domains (2) summary
-
- cd03684
Location:146 → 644
- ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...
- cd04591
Location:655 → 805
- CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria
-
XM_047441808.1 → XP_047297764.1 H(+)/Cl(-) exchange transporter 5 isoform X2
- UniProtKB/TrEMBL
-
A8K4H5
-
XM_047441807.1 → XP_047297763.1 H(+)/Cl(-) exchange transporter 5 isoform X2
- UniProtKB/TrEMBL
-
A8K4H5
Alternate T2T-CHM13v2.0
Genomic
-
NC_060947.1 Alternate T2T-CHM13v2.0
- Range
-
49238534..49416892
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054326432.1 → XP_054182407.1 H(+)/Cl(-) exchange transporter 5 isoform X1
- UniProtKB/TrEMBL
-
A8K4H5
-
XM_054326433.1 → XP_054182408.1 H(+)/Cl(-) exchange transporter 5 isoform X1
- UniProtKB/TrEMBL
-
A8K4H5
-
XM_054326434.1 → XP_054182409.1 H(+)/Cl(-) exchange transporter 5 isoform X2
- UniProtKB/TrEMBL
-
A8K4H5