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    Pno1 partner of NOB1 homolog [ Mus musculus (house mouse) ]

    Gene ID: 66249, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pno1provided by MGI
    Official Full Name
    partner of NOB1 homologprovided by MGI
    Primary source
    MGI:MGI:1913499
    See related
    Ensembl:ENSMUSG00000020116 AllianceGenome:MGI:1913499
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Emi3; Imi3; 1810003N24Rik
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in ribosomal small subunit biogenesis. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of small-subunit processome. Predicted to be active in nucleus. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; heart; and immune system. Orthologous to human PNO1 (partner of NOB1 homolog). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 11.8), CNS E11.5 (RPKM 8.6) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pno1 in Genome Data Viewer
    Location:
    11 A2; 11 9.79 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (17153198..17161589, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (17203198..17211589, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_28703 Neighboring gene 60S ribosomal protein L39 pseudogene Neighboring gene protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) Neighboring gene STARR-seq mESC enhancer starr_28704 Neighboring gene STARR-positive B cell enhancer ABC_E3933 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:17111656-17111843 Neighboring gene dynein axonemal assembly factor 10 Neighboring gene STARR-seq mESC enhancer starr_28705 Neighboring gene C1D nuclear receptor co-repressor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Pno1 tissue-specific expression and its functions related to the immune responses and proteasome activities. Wang X, et al. PLoS One, 2012. PMID 23029399, Free PMC Article
    2. Cloning and characterization of a novel human RNA binding protein gene PNO1. Zhou GJ, et al. DNA Seq, 2004 Jun. PMID 15497447
    3. Identification of novel genes expressed during metanephric induction through single-cell library screening. Abidari JM, et al. Kidney Int, 2000 Jun. PMID 10844592
    4. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
    5. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pno1 gene knockout is Lethal in Embryos.
      Title: Pno1 tissue-specific expression and its functions related to the immune responses and proteasome activities.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of small-subunit processome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein PNO1
    Names
    expressed during mesenchymal induction 3
    induced during mesenchymal induction 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025443.2 → NP_079719.1  RNA-binding protein PNO1

      See identical proteins and their annotated locations for NP_079719.1

      Status: VALIDATED

      Source sequence(s)
      AI837771, AK007324, BY034432
      Consensus CDS
      CCDS24449.1
      UniProtKB/Swiss-Prot
      Q9CPS7
      Related
      ENSMUSP00000020317.8, ENSMUST00000020317.8
      Conserved Domains (2) summary
      smart00322
      Location:173 → 225
      KH; K homology RNA-binding domain
      COG1094
      Location:68 → 243
      Krr1; rRNA processing protein Krr1/Pno1, contains KH domain [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      17153198..17161589 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CPS7.1 GenPept UniProtKB/Swiss-Prot:Q9CPS7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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