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    KLHL35 kelch like family member 35 [ Homo sapiens (human) ]

    Gene ID: 283212, updated on 27-Dec-2024

    Summary

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    Official Symbol
    KLHL35provided by HGNC
    Official Full Name
    kelch like family member 35provided by HGNC
    Primary source
    HGNC:HGNC:26597
    See related
    Ensembl:ENSG00000149243 AllianceGenome:HGNC:26597
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis (RPKM 1.5), brain (RPKM 0.7) and 6 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See KLHL35 in Genome Data Viewer
    Location:
    11q13.4
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (75422394..75433203, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (75351903..75362712, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (75133438..75144248, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75111125-75111988 Neighboring gene Sharpr-MPRA regulatory regions 4651 and 6526 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:75118535-75119034 Neighboring gene small nucleolar RNA, C/D box 15A Neighboring gene small nucleolar RNA, C/D box 15B Neighboring gene ribosomal protein S3 Neighboring gene Sharpr-MPRA regulatory regions 6111 and 12908 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3764 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3765 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:75142886-75143772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:75151983-75152545 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:75167384-75167982 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:75171856-75172358 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75177195-75177867 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75178136-75178783 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75178784-75179430 Neighboring gene uncharacterized LOC105369389 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:75236337-75236837 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3767 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75242693-75243509 Neighboring gene CRISPRi-validated cis-regulatory element chr11.4348 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:75248027-75248527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:75254283-75254784 Neighboring gene VISTA enhancer hs1748 Neighboring gene CRISPRi-validated cis-regulatory element chr11.4355 Neighboring gene CRISPRi-validated cis-regulatory element chr11.4356 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75272978-75273517 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75273518-75274058 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:75274059-75274597 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75276989-75277604 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75277605-75278219 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:75279454-75279954 Neighboring gene serpin family H member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. MxA interacts with and is modified by the SUMOylation machinery. Brantis-de-Carvalho CE, et al. Exp Cell Res, 2015 Jan 1. PMID 25447205
    2. Update on the Kelch-like (KLHL) gene family. Dhanoa BS, et al. Hum Genomics, 2013 May 15. PMID 23676014, Free PMC Article
    3. Mapping the interactome of HPV E6 and E7 oncoproteins with the ubiquitin-proteasome system. Poirson J, et al. FEBS J, 2017 Oct. PMID 28786561
    4. High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153
    5. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. Haenig C, et al. Cell Rep, 2020 Aug 18. PMID 32814053

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • 26597, FLJ33790, DKFZp566C0546

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 35
    Names
    kelch-like 35

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039548.3 → NP_001034637.2  kelch-like protein 35

      See identical proteins and their annotated locations for NP_001034637.2

      Status: VALIDATED

      Source sequence(s)
      AP000744, KF510381
      Consensus CDS
      CCDS44685.2
      UniProtKB/Swiss-Prot
      A2RU06, F5H412, Q6PF15, Q86XM7, Q8NBB1
      Related
      ENSP00000438526.1, ENST00000539798.3
      Conserved Domains (6) summary
      smart00612
      Location:395 → 441
      Kelch; Kelch domain
      smart00225
      Location:42 → 76
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:156 → 255
      BACK; BTB And C-terminal Kelch
      sd00038
      Location:340 → 380
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:31 → 70
      BTB; BTB/POZ domain
      pfam01344
      Location:432 → 470
      Kelch_1; Kelch motif

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      75422394..75433203 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      75351903..75362712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_173583.1: Suppressed sequence

      Description
      NM_173583.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PF15.3 GenPept UniProtKB/Swiss-Prot:Q6PF15

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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