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    PGD1 Pgd1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852860, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PGD1
    Official Full Name
    Pgd1p
    Primary source
    SGD:S000002993
    Locus tag
    YGL025C
    See related
    AllianceGenome:SGD:S000002993; FungiDB:YGL025C; VEuPathDB:YGL025C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HRS1; MED3
    Summary
    Enables RNA polymerase II core promoter sequence-specific DNA binding activity; RNA polymerase II-specific DNA-binding transcription factor binding activity; and transcription coactivator activity. Involved in RNA polymerase II preinitiation complex assembly; cellular response to heat; and regulation of transcription by RNA polymerase II. Part of core mediator complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PGD1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (448764..449957, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene mannosyl-oligosaccharide glucosidase Neighboring gene tryptophan synthase TRP5 Neighboring gene Pib2p Neighboring gene dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The yeast HRS1 gene encodes a polyglutamine-rich nuclear protein required for spontaneous and hpr1-induced deletions between direct repeats. Santos-Rosa H, et al. Genetics, 1996 Mar. PMID 8849881, Free PMC Article
    2. Med3-mediated NADPH generation to help Saccharomyces cerevisiae tolerate hyperosmotic stress. Hou S, et al. Appl Environ Microbiol, 2024 Aug 21. PMID 39082808,
    3. Proteolytic instability and the action of nonclassical transcriptional activators. Wang X, et al. Curr Biol, 2010 May 11. PMID 20417106, Free PMC Article
    4. Isolation and genetic analysis of extragenic suppressors of the hyper-deletion phenotype of the Saccharomyces cerevisiae hpr1 delta mutation. Santos-Rosa H, et al. Genetics, 1995 Jan. PMID 7705651, Free PMC Article
    5. Suppression of Mediator is regulated by Cdk8-dependent Grr1 turnover of the Med3 coactivator. Gonzalez D, et al. Proc Natl Acad Sci U S A, 2014 Feb 18. PMID 24550274, Free PMC Article

    See all (117) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The function of the Mediator tail module component Med3, which is required for transcription activation, is suppressed by the kinase activity of the Cdk8 module.
      Title: Suppression of Mediator is regulated by Cdk8-dependent Grr1 turnover of the Med3 coactivator.
    2. Data suggest that Nhp6p and Med3p regulate gene expression by controlling the local subunit composition of RNA polymerase II.
      Title: Nhp6p and Med3p regulate gene expression by controlling the local subunit composition of RNA polymerase II.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA polymerase II core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to heat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of core mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pgd1p
    NP_011490.2
    • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      448764..449957 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180890.1 → NP_011490.2  TPA: Pgd1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011490.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUB3, P40356, Q6B1W3
      UniProtKB/TrEMBL
      G2WE69
      Conserved Domains (1) summary
      pfam11593
      Location:3 → 397
      Med3; Mediator complex subunit 3 fungal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40356.2

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