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    Ubr7 ubiquitin protein ligase E3 component n-recognin 7 (putative) [ Mus musculus (house mouse) ]

    Gene ID: 66622, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ubr7provided by MGI
    Official Full Name
    ubiquitin protein ligase E3 component n-recognin 7 (putative)provided by MGI
    Primary source
    MGI:MGI:1913872
    See related
    Ensembl:ENSMUSG00000041712 AllianceGenome:MGI:1913872
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5730410I19Rik
    Summary
    Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in protein ubiquitination. Is expressed in central nervous system; eye; genitourinary system; and otocyst. Orthologous to human UBR7 (ubiquitin protein ligase E3 component n-recognin 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 21.0), CNS E11.5 (RPKM 20.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ubr7 in Genome Data Viewer
    Location:
    12 E; 12 52.19 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (102724234..102743960)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (102757975..102777701)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9862 Neighboring gene STARR-positive B cell enhancer ABC_E9390 Neighboring gene predicted gene 20604 Neighboring gene lysosomal enzyme trafficking factor Neighboring gene STARR-seq mESC enhancer starr_33118 Neighboring gene GON7 subunit of KEOPS complex Neighboring gene STARR-seq mESC enhancer starr_33119 Neighboring gene BTB domain containing 7 Neighboring gene cytochrome c oxidase subunit 7C, mitochondrial pseudogene Neighboring gene ribosomal protein S2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of RING-finger ubiquitin ligase UBR7 in mammalian spermatozoa. Zimmerman SW, et al. Cell Tissue Res, 2014 Apr. PMID 24664117
    2. Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization. Powles N, et al. Dev Biol, 2004 Apr 1. PMID 15031102
    3. ACAA2 is a ligand-dependent coactivator for thyroid hormone receptor β1. Wang W, et al. Biochem Biophys Res Commun, 2021 Oct 22. PMID 34474245, Free PMC Article
    4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data provide the first evidence of ubiquitin ligase activity in mammalian spermatozoa and indicate UBR7 involvement in spermiogenesis.
      Title: Identification and characterization of RING-finger ubiquitin ligase UBR7 in mammalian spermatozoa.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative E3 ubiquitin-protein ligase UBR7
    Names
    N-recognin-7
    RING-type E3 ubiquitin transferase UBR7
    NP_079942.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025666.2 → NP_079942.1  putative E3 ubiquitin-protein ligase UBR7

      See identical proteins and their annotated locations for NP_079942.1

      Status: PROVISIONAL

      Source sequence(s)
      AK088208
      Consensus CDS
      CCDS26124.1
      UniProtKB/Swiss-Prot
      Q80UT9, Q8BU04
      UniProtKB/TrEMBL
      Q3U1Z8, Q52KC0
      Related
      ENSMUSP00000041247.7, ENSMUST00000046404.8
      Conserved Domains (2) summary
      cd15542
      Location:134 → 185
      PHD_UBR7; PHD finger found in putative E3 ubiquitin-protein ligase UBR7
      pfam02207
      Location:56 → 113
      zf-UBR; Putative zinc finger in N-recognin (UBR box)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      102724234..102743960
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BU04.1 GenPept UniProtKB/Swiss-Prot:Q8BU04

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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