Kat6b K(lysine) acetyltransferase 6B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kat6bprovided by MGI
Official Full Name: K(lysine) acetyltransferase 6Bprovided by MGI
Primary source: MGI:MGI:1858746
See related: Ensembl:ENSMUSG00000021767 AllianceGenome:MGI:1858746
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: qkf; Morf; Myst4; MYST-4; querkopf; mKIAA0383; B130044K16Rik
Summary: Enables histone acetyltransferase activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in chromatin. Predicted to be part of MOZ/MORF histone acetyltransferase complex. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; facial prominence; genitourinary system; and limb mesenchyme. Used to study Noonan syndrome. Human ortholog(s) of this gene implicated in Ohdo syndrome, SBBYS variant; bipolar disorder; breast cancer; and leiomyoma. Orthologous to human KAT6B (lysine acetyltransferase 6B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 5.4), frontal lobe adult (RPKM 5.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 A3; 14 11.73 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (21549284..21722546)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (21499216..21672478)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The histone acetyltransferase KAT6B is required for hematopoietic stem cell development and function.
Title: The histone acetyltransferase KAT6B is required for hematopoietic stem cell development and function.
SNORD17-mediated KAT6B mRNA 2'-O-methylation regulates vasculogenic mimicry in glioblastoma cells.
Title: SNORD17-mediated KAT6B mRNA 2'-O-methylation regulates vasculogenic mimicry in glioblastoma cells.
work identifies KAT6B as a novel epigenetic regulator of hematopoietic differentiation and a target to improve aged immune function.
Title: Aging-associated decrease in the histone acetyltransferase KAT6B is linked to altered hematopoietic stem cell differentiation.
Fluorescence correlation spectroscopy analyses suggest a more compact chromatin organization in K6b-/- cells and impaired interactions of Oct4 and Nanog with chromatin.
Title: Kat6b Modulates Oct4 and Nanog Binding to Chromatin in Embryonic Stem Cells and Is Required for Efficient Neural Differentiation.
Silence of lysine acetyltransferase 6B (KAT6B) suppressed lipopolysaccharide(LPS)-induced IL-6 production in peritoneal macrophages.
Title: [KAT6B promotes LPS-triggered IL-6 production via enhancing recruitment of H3K23 acetylation to IL-6 promoter region].
Data indicate that Myst4, Jmjd2b, Aof1 genes are regulated by H3K9me under hyperinsulinemia/hyperglycemia.
Title: Histone H3 lysine 4 monomethylation (H3K4me1) and H3 lysine 9 monomethylation (H3K9me1): distribution and their association in regulating gene expression under hyperglycaemic/hyperinsulinemic conditions in 3T3 cells.
Data show that H3 acetylation by Myst4 is important for neural, craniofacial, and skeletal morphogenesis, mainly through its ability to specifically regulating the MAPK signaling pathway.
Title: Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome-like phenotype and hyperactivated MAPK signaling in humans and mice.
Deregulation of polyamine biosynthesis alters intrinsic histone acetyltransferase and deacetylase activities in murine skin and tumors.
Title: Deregulation of polyamine biosynthesis alters intrinsic histone acetyltransferase and deacetylase activities in murine skin and tumors.
MORF4 has a role in cellular aging, and MRG15 associates with both histone deacetylases and histone acetyl transferase complexes [review]
Title: The role of the MORF/MRG family of genes in cell growth, differentiation, DNA repair, and thereby aging.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (1)
Gene trapped (1) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:225283

MYST4_3804 (e-PCR)
- UniSTS:468538

RH136273 (e-PCR)
- UniSTS:210266

NoName (e-PCR)
- UniSTS:491110

AI507552 (e-PCR)
- UniSTS:180613

D14Ertd725e (e-PCR), detects polymorphism
- UniSTS:167146

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone H2AK5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AK9 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BK12 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BK5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3 acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K122 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K14 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K14 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3K18 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K23 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K27 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K36 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K4 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K56 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K9 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K12 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K16 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K8 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptide-lysine-N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables peptide-lysine-N-acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISS Inferred from Sequence or Structural Similarity more info
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in nucleosome assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of developmental process	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of hemopoiesis	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of MOZ/MORF histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MOZ/MORF histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of MOZ/MORF histone acetyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
part_of nucleosome	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: histone acetyltransferase KAT6B

Names: MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4; MYST histone acetyltransferase monocytic leukemia 4; histone acetyltransferase MYST4; histone acetyltransferase querkopf; monocytic leukemia; protein querkopf

NP_001192170.1

EC 2.3.1.48

NP_001395624.1

EC 2.3.1.48

NP_001395625.1

EC 2.3.1.48

NP_059507.2

EC 2.3.1.48

XP_006519326.1

EC 2.3.1.48

XP_006519327.1

EC 2.3.1.48

XP_006519328.1

EC 2.3.1.48

XP_006519332.1

EC 2.3.1.48

XP_017171571.1

EC 2.3.1.48

XP_017171573.1

EC 2.3.1.48

XP_030103747.1

EC 2.3.1.48

XP_030103748.1

EC 2.3.1.48

XP_036014649.1

EC 2.3.1.48

XP_036014650.1

EC 2.3.1.48

XP_036014651.1

EC 2.3.1.48

XP_036014652.1

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001205241.2 → NP_001192170.1 histone acetyltransferase KAT6B isoform 1

See identical proteins and their annotated locations for NP_001192170.1

Status: VALIDATED

Source sequence(s)

AC115122, AC148978

Consensus CDS

CCDS59615.1

UniProtKB/TrEMBL

Q3UH94

Related

ENSMUSP00000138511.2, ENSMUST00000182855.8

Conserved Domains (4) summary

smart00526
Location:94 → 168

H15; Domain in histone families 1 and 5

PLN00104
Location:430 → 698

PLN00104; MYST -like histone acetyltransferase; Provisional

cd15527
Location:272 → 318

PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

cd15689
Location:213 → 271

PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)
NM_001408695.1 → NP_001395624.1 histone acetyltransferase KAT6B isoform 1

Status: VALIDATED

Source sequence(s)

AC115122, AC148978
NM_001408696.1 → NP_001395625.1 histone acetyltransferase KAT6B isoform 2

Status: VALIDATED

Source sequence(s)

AC115122, AC148978

UniProtKB/Swiss-Prot

E9QK86, Q7TNW5, Q8BG35, Q8BRB7, Q8C441, Q9JKX5

Related

ENSMUSP00000138421.2, ENSMUST00000182964.3
NM_017479.4 → NP_059507.2 histone acetyltransferase KAT6B isoform 1

See identical proteins and their annotated locations for NP_059507.2

Status: VALIDATED

Source sequence(s)

AC115122, AC148978

Consensus CDS

CCDS59615.1

UniProtKB/TrEMBL

Q3UH94

Related

ENSMUSP00000138377.2, ENSMUST00000182405.9

Conserved Domains (4) summary

smart00526
Location:94 → 168

H15; Domain in histone families 1 and 5

PLN00104
Location:430 → 698

PLN00104; MYST -like histone acetyltransferase; Provisional

cd15527
Location:272 → 318

PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

cd15689
Location:213 → 271

PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

21549284..21722546

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006519265.5 → XP_006519328.1 histone acetyltransferase KAT6B isoform X1

See identical proteins and their annotated locations for XP_006519328.1

UniProtKB/TrEMBL

A0A5F8MQ39, Q3UH94

Conserved Domains (4) summary

smart00526
Location:94 → 168

H15; Domain in histone families 1 and 5

PLN00104
Location:721 → 989

PLN00104; MYST -like histone acetyltransferase; Provisional

cd15527
Location:272 → 318

PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

cd15618
Location:213 → 270

PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
XM_036158758.1 → XP_036014651.1 histone acetyltransferase KAT6B isoform X6

UniProtKB/TrEMBL

Q3UH94

Conserved Domains (4) summary

smart00526
Location:94 → 168

H15; Domain in histone families 1 and 5

PLN00104
Location:430 → 698

PLN00104; MYST -like histone acetyltransferase; Provisional

cd15527
Location:272 → 318

PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

cd15689
Location:213 → 271

PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)
XM_006519264.5 → XP_006519327.1 histone acetyltransferase KAT6B isoform X1

See identical proteins and their annotated locations for XP_006519327.1

UniProtKB/TrEMBL

A0A5F8MQ39, Q3UH94

Conserved Domains (4) summary

smart00526
Location:94 → 168

H15; Domain in histone families 1 and 5

PLN00104
Location:721 → 989

PLN00104; MYST -like histone acetyltransferase; Provisional

cd15527
Location:272 → 318

PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

cd15618
Location:213 → 270

PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
XM_036158756.1 → XP_036014649.1 histone acetyltransferase KAT6B isoform X1

UniProtKB/TrEMBL

A0A5F8MQ39, Q3UH94

Related

ENSMUSP00000159058.2, ENSMUST00000238837.2

Conserved Domains (4) summary

smart00526
Location:94 → 168

H15; Domain in histone families 1 and 5

PLN00104
Location:721 → 989

PLN00104; MYST -like histone acetyltransferase; Provisional

cd15527
Location:272 → 318

PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

cd15618
Location:213 → 270

PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
XM_036158759.1 → XP_036014652.1 histone acetyltransferase KAT6B isoform X7

UniProtKB/TrEMBL

Q3UH94

Conserved Domains (4) summary

smart00526
Location:94 → 168

H15; Domain in histone families 1 and 5

PLN00104
Location:367 → 635

PLN00104; MYST -like histone acetyltransferase; Provisional

cd15527
Location:272 → 310

PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

cd15689
Location:213 → 271

PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)
XM_030247887.2 → XP_030103747.1 histone acetyltransferase KAT6B isoform X1

UniProtKB/TrEMBL

A0A5F8MQ39, Q3UH94

Conserved Domains (4) summary

smart00526
Location:94 → 168

H15; Domain in histone families 1 and 5

PLN00104
Location:721 → 989

PLN00104; MYST -like histone acetyltransferase; Provisional

cd15527
Location:272 → 318

PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

cd15618
Location:213 → 270

PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
XM_017316082.3 → XP_017171571.1 histone acetyltransferase KAT6B isoform X2

UniProtKB/TrEMBL

Q3UH94

Conserved Domains (4) summary

smart00526
Location:94 → 168

H15; Domain in histone families 1 and 5

PLN00104
Location:721 → 989

PLN00104; MYST -like histone acetyltransferase; Provisional

cd15527
Location:272 → 318

PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

cd15618
Location:213 → 270

PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
XM_006519263.5 → XP_006519326.1 histone acetyltransferase KAT6B isoform X1

See identical proteins and their annotated locations for XP_006519326.1

UniProtKB/TrEMBL

A0A5F8MQ39, Q3UH94

Conserved Domains (4) summary

smart00526
Location:94 → 168

H15; Domain in histone families 1 and 5

PLN00104
Location:721 → 989

PLN00104; MYST -like histone acetyltransferase; Provisional

cd15527
Location:272 → 318

PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

cd15618
Location:213 → 270

PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
XM_036158757.1 → XP_036014650.1 histone acetyltransferase KAT6B isoform X3

UniProtKB/TrEMBL

Q3UH94

Conserved Domains (4) summary

smart00526
Location:94 → 168

H15; Domain in histone families 1 and 5

PLN00104
Location:584 → 852

PLN00104; MYST -like histone acetyltransferase; Provisional

cd15527
Location:272 → 318

PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

cd15618
Location:213 → 270

PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
XM_017316084.3 → XP_017171573.1 histone acetyltransferase KAT6B isoform X7

UniProtKB/TrEMBL

Q3UH94

Conserved Domains (4) summary

smart00526
Location:94 → 168

H15; Domain in histone families 1 and 5

PLN00104
Location:367 → 635

PLN00104; MYST -like histone acetyltransferase; Provisional

cd15527
Location:272 → 310

PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

cd15689
Location:213 → 271

PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)
XM_006519269.5 → XP_006519332.1 histone acetyltransferase KAT6B isoform X5

UniProtKB/TrEMBL

Q3UH94

Conserved Domains (2) summary

PLN00104
Location:436 → 704

PLN00104; MYST -like histone acetyltransferase; Provisional

cd15527
Location:1 → 33

PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
XM_030247888.2 → XP_030103748.1 histone acetyltransferase KAT6B isoform X8

Conserved Domains (1) summary

PLN00104
Location:5 → 57

PLN00104; MYST -like histone acetyltransferase; Provisional