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    Tekt5 tektin 5 [ Mus musculus (house mouse) ]

    Gene ID: 70426, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tekt5provided by MGI
    Official Full Name
    tektin 5provided by MGI
    Primary source
    MGI:MGI:1917676
    See related
    Ensembl:ENSMUSG00000039179 AllianceGenome:MGI:1917676
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3300001K11Rik
    Summary
    Involved in flagellated sperm motility. Is active in axonemal A tubule inner sheath and sperm flagellum. Orthologous to human TEKT5 (tektin 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 92.6) and cerebellum adult (RPKM 4.3) See more
    Orthologs
    human all
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    Genomic context

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    See Tekt5 in Genome Data Viewer
    Location:
    16 A1; 16 5.58 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (10175816..10213319, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (10357952..10395455, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene 1600 Neighboring gene predicted gene, 30724 Neighboring gene predicted gene, 41419 Neighboring gene STARR-positive B cell enhancer ABC_E10886 Neighboring gene nucleotide binding protein 1 Neighboring gene trans-golgi network vesicle protein 23A Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:10469529-10469712 Neighboring gene predicted gene, 41420

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comprehensive Analysis of Mouse Cancer/Testis Antigen Functions in Cancer Cells and Roles of TEKT5 in Cancer Cells and Testicular Germ Cells. Aoki N, et al. Mol Cell Biol, 2019 Sep 1. PMID 31208979, Free PMC Article
    2. Characterization of a novel tektin member, TEKT5, in mouse sperm. Cao W, et al. J Androl, 2011 Jan-Feb. PMID 20378928, Free PMC Article
    3. De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking. Chen Z, et al. Cell, 2023 Nov 9. PMID 37865089, Free PMC Article
    4. In-cell structural insight into the stability of sperm microtubule doublet. Tai L, et al. Cell Discov, 2023 Nov 21. PMID 37989994, Free PMC Article
    5. Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility. Zhou L, et al. Cell, 2023 Jun 22. PMID 37295417

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results showed that TEKT5 controls tubulin stability to enhance the growth and survival of cancer cells and to promote sperm morphogenesis.
      Title: Comprehensive Analysis of Mouse Cancer/Testis Antigen Functions in Cancer Cells and Roles of TEKT5 in Cancer Cells and Testicular Germ Cells.
    2. TEKT5 protein was highly expressed in mouse spermatids and was localized in the flagellar accessory structures.
      Title: Characterization of a novel tektin member, TEKT5, in mouse sperm.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC144895

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in flagellated sperm motility IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axonemal A tubule inner sheath IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in sperm flagellum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tektin-5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291001.2 → NP_001277930.1  tektin-5

      See identical proteins and their annotated locations for NP_001277930.1

      Status: VALIDATED

      Source sequence(s)
      AC154311
      Consensus CDS
      CCDS70683.1
      UniProtKB/Swiss-Prot
      D5HP88, G5E8A8, Q14BE9
      Related
      ENSMUSP00000046824.7, ENSMUST00000043415.13
      Conserved Domains (1) summary
      pfam03148
      Location:95 → 474
      Tektin; Tektin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      10175816..10213319 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001099275.1: Suppressed sequence

      Description
      NM_001099275.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5E8A8.1 GenPept UniProtKB/Swiss-Prot:G5E8A8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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