Psme4 proteasome (prosome, macropain) activator subunit 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Psme4provided by MGI
Official Full Name: proteasome (prosome, macropain) activator subunit 4provided by MGI
Primary source: MGI:MGI:2143994
See related: Ensembl:ENSMUSG00000040850 AllianceGenome:MGI:2143994
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TEMO; Blm10; mBlm10; mKIAA0077
Summary: Enables lysine-acetylated histone binding activity and peptidase activator activity. Involved in DNA repair; proteasomal ubiquitin-independent protein catabolic process; and sperm DNA condensation. Located in cytosol and nucleus. Part of spermatoproteasome complex. Is expressed in craniocervical region bone; nervous system; sensory organ; and submandibular gland primordium. Used to study visceral heterotaxy. Orthologous to human PSME4 (proteasome activator subunit 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 36.4), heart adult (RPKM 19.6) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A4; 11 18.16 cM

Exon count:: 50

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (30721753..30831150)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (30771775..30881150)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockout of PA200 improves proteasomal degradation and myelination in a proteotoxic neuropathy.
Title: Knockout of PA200 improves proteasomal degradation and myelination in a proteotoxic neuropathy.
Proteasome activator PA200 regulates myofibroblast differentiation.
Title: Proteasome activator PA200 regulates myofibroblast differentiation.
Study demonstrated that Psme3/Psme4 double KO (dKO) male mice are completely infertile and showed the up-regulation of several proteins involved in oxidative stress response in dKO sperms. These results suggest the important role of PA28gamma and PA200 in male fertility.
Title: Proteasome activators, PA28γ and PA200, play indispensable roles in male fertility.
PA200/Blm10 specifically targets the core histones for acetylation-mediated degradation by proteasomes, providing mechanisms by which acetylation regulates histone degradation, DNA repair, and spermatogenesis.
Title: Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125843 (e-PCR)
- UniSTS:162586

AU041366 (e-PCR)
- UniSTS:160078

RH124856 (e-PCR)
- UniSTS:161678

fl05f06.x1 (e-PCR)
- UniSTS:201902

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lysine-acetylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables lysine-acetylated histone binding	IDA Inferred from Direct Assay more info	PubMed
enables peptidase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables proteasome binding	IBA Inferred from Biological aspect of Ancestor more info
enables proteasome binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasomal ubiquitin-independent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasomal ubiquitin-independent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in sperm DNA condensation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of spermatoproteasome complex	IBA Inferred from Biological aspect of Ancestor more info
part_of spermatoproteasome complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: proteasome activator complex subunit 4

Names: proteasome activator PA200; protein BLM10 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134013.3 → NP_598774.2 proteasome activator complex subunit 4

Status: VALIDATED

Source sequence(s)

AF296169, AK131932, AK169447, AL662891, BE944080, CV557020, CV557303, CX566261

Consensus CDS

CCDS36124.1

UniProtKB/Swiss-Prot

C4IXU5, Q3TER7, Q3V2B7, Q5SSW2, Q6ZQJ7, Q7TMY9, Q8K0K0, Q99KM2, Q9ESY1

Related

ENSMUSP00000045460.8, ENSMUST00000041231.14

Conserved Domains (3) summary

sd00044
Location:1571 → 1591

HEAT; HEAT repeat [structural motif]

pfam11919
Location:1757 → 1842

DUF3437; Domain of unknown function (DUF3437)

pfam16507
Location:330 → 828

BLM10_mid; Proteasome-substrate-size regulator, mid region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

30721753..30831150

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011243649.4 → XP_011241951.1 proteasome activator complex subunit 4 isoform X1

Conserved Domains (1) summary

pfam16507
Location:330 → 828

BLM10_mid; Proteasome-substrate-size regulator, mid region
XM_036156189.1 → XP_036012082.1 proteasome activator complex subunit 4 isoform X2

Conserved Domains (3) summary

sd00044
Location:1380 → 1400

HEAT; HEAT repeat [structural motif]

pfam11919
Location:1566 → 1651

DUF3437; Domain of unknown function (DUF3437)

pfam16507
Location:139 → 637

BLM10_mid; Proteasome-substrate-size regulator, mid region
XM_030245449.1 → XP_030101309.1 proteasome activator complex subunit 4 isoform X3

Conserved Domains (2) summary

sd00044
Location:729 → 749

HEAT; HEAT repeat [structural motif]

pfam11919
Location:915 → 1000

DUF3437; Domain of unknown function (DUF3437)