Matn2 matrilin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Matn2provided by MGI
Official Full Name: matrilin 2provided by MGI
Primary source: MGI:MGI:109613
See related: Ensembl:ENSMUSG00000022324 AllianceGenome:MGI:109613
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Crtm2; matrilin-2
Summary: Predicted to enable calcium ion binding activity. Predicted to be an extracellular matrix structural constituent. Acts upstream of or within neurogenesis and response to axon injury. Located in basement membrane. Part of matrilin complex. Is expressed in several structures, including brain; chondrocranium; forelimb; genitourinary system; and spinal cord meninges. Orthologous to human MATN2 (matrilin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in bladder adult (RPKM 46.5), subcutaneous fat pad adult (RPKM 34.4) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 B3.1; 15 13.98 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (34306827..34436388)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (34306681..34436242)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that the mRNA and protein levels of matrilin-2 were increased after irradiation treatment in both mouse lung tissue and human pulmonary alveolar epithelial cells (HPAEpiC).
Title: Matrilin-2 regulates proliferation, apoptosis and cell cycle during radiation-induced injury in HPAEpiC cell.
Matrilin-2 induces post-burn inflammatory responses as an endogenous danger signal, partly through a TLR4-mediated mechanism
Title: The extracellular matrix protein matrilin-2 induces post-burn inflammatory responses as an endogenous danger signal.
Matn2 functions as a tumor suppressor in hepatocarcinogenesis, and in this process activation of EGFR together with that of Erk1/2, as well as inactivation of GSK-3beta, play strategic roles.
Title: Lack of Matrilin-2 favors liver tumor development via Erk1/2 and GSK-3β pathways in vivo.
The absence of matrilin-2 has no effect on hepatic stellate cell activation and regression kinetics, synthetic activity, proliferative capacity, motility, or HSC apoptosis.
Title: Upregulation of matrilin-2 expression in murine hepatic stellate cells during liver injury has no effect on fibrosis formation and resolution.
MATN2 is a deleterious endogenous neuroaxonal injury response signal that activates innate immune cells.
Title: Axonally derived matrilin-2 induces proinflammatory responses that exacerbate autoimmune neuroinflammation.
Matrilin-2 may play an important role in the communication of matrix to matrix and matrix to cells and will be used as a potential biomarker in the early stage of osteoarthritis of articular cartilage.
Title: Matrilin-2 is a widely distributed extracellular matrix protein and a potential biomarker in the early stage of osteoarthritis in articular cartilage.
matrilin 2 is a permissive substrate for axonal growth and cell migration, and that it is required for successful nerve regeneration.
Title: The extracellular-matrix protein matrilin 2 participates in peripheral nerve regeneration.
Expression of matrilin-2 during maturation of mouse skeletal tissues
Title: Expression of matrilins during maturation of mouse skeletal tissues.
Matrilin-2 null mice show no gross abnormalities during embryonic or adult development, are fertile, and have a normal lifespan.
Title: Mice lacking the extracellular matrix adaptor protein matrilin-2 develop without obvious abnormalities.
matrilin-2, a filament-forming protein widely distributed in extracellular matrices.
Title: Comparative analysis of the mouse and human genes (Matn2 and MATN2) for matrilin-2, a filament-forming protein widely distributed in extracellular matrices.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_15781-15782:1033153405:3 (e-PCR)
- UniSTS:267902

MARC_15781-15782:1041966675:1 (e-PCR)
- UniSTS:267902

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dendrite regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extracellular matrix organization	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within glial cell migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuron migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuron projection development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to axon injury	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in collagen-containing extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	HDA more info	PubMed
part_of matrilin complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: matrilin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001358780.1 → NP_001345709.1 matrilin-2 isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC126028, AC133101, AC144632

Consensus CDS

CCDS88747.1

UniProtKB/Swiss-Prot

E9QPK9, O08746, Q8R542

UniProtKB/TrEMBL

Q99K64

Related

ENSMUSP00000154040.2, ENSMUST00000227759.2

Conserved Domains (4) summary

cd01475
Location:54 → 276

vWA_Matrilin; VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. ...

pfam10393
Location:911 → 953

Matrilin_ccoil; Trimeric coiled-coil oligomerization domain of matrilin

pfam14670
Location:570 → 605

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00057
Location:652 → 892

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
NM_001427153.1 → NP_001414082.1 matrilin-2 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC133101, AC144632

UniProtKB/TrEMBL

A0A2I3BRF3

Related

ENSMUSP00000154572.2, ENSMUST00000228570.2
NM_016762.2 → NP_058042.2 matrilin-2 isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AK138211, AK163818, BY146293

Consensus CDS

CCDS37056.1

UniProtKB/TrEMBL

Q569V0

Related

ENSMUSP00000022947.6, ENSMUST00000022947.7

Conserved Domains (4) summary

cd01475
Location:54 → 276

vWA_Matrilin; VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. ...

pfam10393
Location:892 → 934

Matrilin_ccoil; Trimeric coiled-coil oligomerization domain of matrilin

pfam14670
Location:570 → 605

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00057
Location:652 → 873

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...