Sec62 SEC62 homolog, preprotein translocation [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sec62provided by MGI
Official Full Name: SEC62 homolog, preprotein translocationprovided by MGI
Primary source: MGI:MGI:1916526
See related: Ensembl:ENSMUSG00000027706 AllianceGenome:MGI:1916526
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HTP1; Dtrp1; Tloc1; 3100002M17Rik
Summary: Predicted to be involved in post-translational protein targeting to membrane, translocation. Predicted to act upstream of or within post-translational protein targeting to endoplasmic reticulum membrane. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum and membrane. Orthologous to human SEC62 (SEC62 homolog, preprotein translocation factor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 31.7), frontal lobe adult (RPKM 26.4) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 A3; 3 14.29 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (30847025..30875412)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (30792876..30821263)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

identify Sec62 as a critical molecular component in maintenance and recovery of endoplasmic reticulum homeostasis
Title: Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery.
Interaction of ribosomes and Sec62 with the core Sec61 translocon is mutually exclusive.
Title: Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation.
The Sec62 protein plays a role in post-translational transport of presecretory proteins into endoplasmic reticulum.
Title: Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D3Dcr1 (e-PCR), detects polymorphism
- UniSTS:507659

MARC_17479-17480:1016465460:1 (e-PCR)
- UniSTS:268312

AI844545 (e-PCR)
- UniSTS:164204

AW545092 (e-PCR)
- UniSTS:178821

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within post-translational protein targeting to endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info	PubMed
involved_in post-translational protein targeting to membrane, translocation	IBA Inferred from Biological aspect of Ancestor more info
involved_in post-translational protein targeting to membrane, translocation	ISO Inferred from Sequence Orthology more info
involved_in post-translational protein targeting to membrane, translocation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: translocation protein SEC62

Names: SEC62 homolog; TP-1; translocation protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357528.1 → NP_001344457.1 translocation protein SEC62 isoform 1

Status: VALIDATED

Source sequence(s)

AC158135

Conserved Domains (2) summary

pfam03839
Location:170 → 304

Sec62; Translocation protein Sec62

cl27000
Location:290 → 369

TFIIFa; Transcription initiation factor IIF, alpha subunit, N-terminal region of RAP74. Subunit of transcription initiation complex involved in initiation, elongation and promoter escape.Tetramer of 2 alpha and 2 beta TFIIF subunits interacts directly with RNA ...
NM_027016.2 → NP_081292.1 translocation protein SEC62 isoform 2

See identical proteins and their annotated locations for NP_081292.1

Status: VALIDATED

Source sequence(s)

AC158135, DV657309

Consensus CDS

CCDS17286.1

UniProtKB/Swiss-Prot

Q6NX81, Q8BU14

Related

ENSMUSP00000029256.8, ENSMUST00000029256.9

Conserved Domains (1) summary

pfam03839
Location:170 → 292

Sec62; Translocation protein Sec62