Pnliprp2 pancreatic lipase-related protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pnliprp2provided by MGI
Official Full Name: pancreatic lipase-related protein 2provided by MGI
Primary source: MGI:MGI:1336202
See related: Ensembl:ENSMUSG00000025091 AllianceGenome:MGI:1336202
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PLRP2
Summary: Enables triacylglycerol lipase activity. Acts upstream of or within cellular defense response; intestinal lipid catabolic process; and response to bacterium. Predicted to be located in neuron projection and zymogen granule membrane. Predicted to be active in extracellular space. Is expressed in pancreas tip epithelium. Orthologous to human PNLIPRP2 (pancreatic lipase related protein 2 (gene/pseudogene)). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in small intestine adult (RPKM 66.4), stomach adult (RPKM 31.6) and 4 other tissues See more
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Genomic context

Location:: 19 D2; 19 54.5 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (58748155..58765966)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (58759723..58777534)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pancreatic lipase-related protein 2 is selectively expressed by peritubular myoid cells in the murine testis and sustains long-term spermatogenesis.
Title: Pancreatic lipase-related protein 2 is selectively expressed by peritubular myoid cells in the murine testis and sustains long-term spermatogenesis.
PLRP2 selectively localizes synaptic membrane proteins via acyl-chain remodeling of phospholipids.
Title: PLRP2 selectively localizes synaptic membrane proteins via acyl-chain remodeling of phospholipids.
Decreased T-cell mediated hepatic injury in concanavalin A-treated PLRP2-deficient mice.
Title: Decreased T-cell mediated hepatic injury in concanavalin A-treated PLRP2-deficient mice.
Our results indicate that Plrp2 can be activated in the liver and is responsible for the increased RE hydrolases (REH) activity in the liver of mice fed vitamin A-deficient diet (VAD)
Title: Pancreatic lipase-related protein 2 is responsible for the increased hepatic retinyl ester hydrolase activity in vitamin A-deficient mice.
Data suggest that the conditional expression of mPlrp2 and mClps is involved in the hydrolysis of retinyl esters in the mouse liver.
Title: The mPlrp2 and mClps genes are involved in the hydrolysis of retinyl esters in the mouse liver.
PLRP2 induction by IL-4 in cytotoxic T-lymphocytes (CTLs) and reevaluation of the negative effects of its gene ablation on cytotoxicity are reported.
Title: Pancreatic lipase-related protein 2 (PLRP2) induction by IL-4 in cytotoxic T lymphocytes (CTLs) and reevaluation of the negative effects of its gene ablation on cytotoxicity.
BSSL and PLRP2 responsible for fat digestion as long as milk is the main food. Milk-borne BSSL is able to compensate for a slower ontogeny of pancreatic BSSL expression in the mouse.
Title: Bile salt-stimulated lipase and pancreatic lipase-related protein 2 are the dominating lipases in neonatal fat digestion in mice and rats.
study concluded that pancreatic lipase-related protein 2 is the major colipase-dependent lipase in the pancreas of newborn mice
Title: Pancreatic lipase-related protein 2 is the major colipase-dependent pancreatic lipase in suckling mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

General gene information

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Markers

D19Mgc10 (e-PCR)
- UniSTS:256835

Pnliprp2 (e-PCR), detects polymorphism
- UniSTS:546958

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables galactolipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables galactolipase activity	ISO Inferred from Sequence Orthology more info
enables galactolipase activity	ISS Inferred from Sequence or Structural Similarity more info
enables lipase activity	ISO Inferred from Sequence Orthology more info
enables lipoprotein lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables monoacylglycerol lipase activity	ISO Inferred from Sequence Orthology more info
enables monoacylglycerol lipase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phospholipase A1 activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase activity	ISO Inferred from Sequence Orthology more info
enables phospholipase activity	ISS Inferred from Sequence or Structural Similarity more info
enables triacylglycerol lipase activity	IDA Inferred from Direct Assay more info	PubMed
enables triacylglycerol lipase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular defense response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cholesterol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in galactolipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in galactolipid catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in high-density lipoprotein particle remodeling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intestinal lipid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylcholine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phospholipid catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phospholipid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in triglyceride catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in triglyceride catabolic process	IEA Inferred from Electronic Annotation more info
involved_in triglyceride catabolic process	ISO Inferred from Sequence Orthology more info
involved_in triglyceride catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISS Inferred from Sequence or Structural Similarity more info
located_in zymogen granule membrane	IEA Inferred from Electronic Annotation more info
located_in zymogen granule membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pancreatic lipase-related protein 2

Names: PL-RP2; cytotoxic T-lymphocyte lipase; galactolipase; triacylglycerol lipase

NP_035258.2

EC 3.1.1.26

EC 3.1.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011128.2 → NP_035258.2 pancreatic lipase-related protein 2 precursor

See identical proteins and their annotated locations for NP_035258.2

Status: VALIDATED

Source sequence(s)

AK008021, AK131882, BC094923

Consensus CDS

CCDS38030.1

UniProtKB/Swiss-Prot

P17892, Q4VBW7

Related

ENSMUSP00000026081.4, ENSMUST00000026081.5

Conserved Domains (3) summary

cd00707
Location:65 → 363

Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

cd01759
Location:370 → 482

PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...

pfam00151
Location:31 → 367

Lipase; Lipase