Sulf2 sulfatase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sulf2provided by MGI
Official Full Name: sulfatase 2provided by MGI
Primary source: MGI:MGI:1919293
See related: Ensembl:ENSMUSG00000006800 AllianceGenome:MGI:1919293
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MSulf-2; mKIAA1247; 2010004N24Rik
Summary: Enables N-acetylglucosamine-6-sulfatase activity. Involved in several processes, including esophagus smooth muscle contraction; glomerular filtration; and skeletal system development. Acts upstream of or within several processes, including liver regeneration; positive regulation of canonical Wnt signaling pathway; and regulation of hepatocyte proliferation. Located in plasma membrane. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; limb; and sensory organ. Orthologous to human SULF2 (sulfatase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in ovary adult (RPKM 145.3), limb E14.5 (RPKM 91.2) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 86.31 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (165915819..165997603, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (166073899..166155683, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SULF2 enhances GDF15-SMAD axis to facilitate the initiation and progression of pancreatic cancer.
Title: SULF2 enhances GDF15-SMAD axis to facilitate the initiation and progression of pancreatic cancer.
Regulation of fractone heparan sulfate composition in young and aged subventricular zone neurogenic niches.
Title: Regulation of fractone heparan sulfate composition in young and aged subventricular zone neurogenic niches.
ON-bipolar cell gene expression during retinal degeneration: Implications for optogenetic visual restoration.
Title: ON-bipolar cell gene expression during retinal degeneration: Implications for optogenetic visual restoration.
Knockout of sulfatase 2 is associated with decreased steatohepatitis and fibrosis in a mouse model of nonalcoholic fatty liver disease.
Title: Knockout of sulfatase 2 is associated with decreased steatohepatitis and fibrosis in a mouse model of nonalcoholic fatty liver disease.
The extracellular sulfatase SULF2 promotes liver tumorigenesis by stimulating assembly of a promoter-looping GLI1-STAT3 transcriptional complex.
Title: The extracellular sulfatase SULF2 promotes liver tumorigenesis by stimulating assembly of a promoter-looping GLI1-STAT3 transcriptional complex.
At initiation of gliogenesis in mouse, Sulf2 is expressed in ventral neural progenitors of the embryonic spinal cord, including in Olig2-expressing cells of the pMN domain. We found that sulf2 deletion, while not affecting oligodendrocyte precursor cells production, impairs generation of a previously unknown Olig2-expressing pMN-derived cell subtype that does not upregulate Sox10, PDGFRalpha or Olig1.
Title: Sulfatase 2 promotes generation of a spinal cord astrocyte subtype that stands out through the expression of Olig2.
Shh signaling requires the coordinated activity of Sulf1 and Sulf2 in order to reach that threshold in the mouse ventral spinal cord
Title: Sulfatase 2 Modulates Fate Change from Motor Neurons to Oligodendrocyte Precursor Cells through Coordinated Regulation of Shh Signaling with Sulfatase 1.
sulfate 6-O-endosulfatase 2 expression in type II alveolar epithelial cells plays a protective role in epithelial injury, inflammation and mortality
Title: Epithelial Deletion of Sulf2 Exacerbates Bleomycin-Induced Lung Injury, Inflammation, and Mortality.
Sulf1 and Sulf2 play indispensable roles to maintain glomerular integrity and protective roles in diabetic nephropathy, probably by growth factor modulation.
Title: Heparan sulfate 6-O-endosulfatases, Sulf1 and Sulf2, regulate glomerular integrity by modulating growth factor signaling.
Expression of the heparan sulfate 6-O-endosulfatases, Sulf1 and Sulf2, in the avian and mammalian inner ear suggests a role for sulfation during inner ear development.
Title: Expression of the heparan sulfate 6-O-endosulfatases, Sulf1 and Sulf2, in the avian and mammalian inner ear suggests a role for sulfation during inner ear development.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (3) 1 citation
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sulf2 (e-PCR), detects polymorphism
- UniSTS:498730

Sulf2 (e-PCR), detects polymorphism
- UniSTS:498510

RH127484 (e-PCR)
- UniSTS:210794

NoName (e-PCR)
- UniSTS:234604

RH136389 (e-PCR)
- UniSTS:210379

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-acetylglucosamine-6-sulfatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acetylglucosamine-6-sulfatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables N-acetylglucosamine-6-sulfatase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables arylsulfatase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables arylsulfatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables glycosaminoglycan binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in bone development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chondrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic skeletal system development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in esophagus smooth muscle contraction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in glial cell-derived neurotrophic factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in glomerular basement membrane development	IBA Inferred from Biological aspect of Ancestor more info
involved_in glomerular basement membrane development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in glomerular filtration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in heparan sulfate proteoglycan metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in heparan sulfate proteoglycan metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heparan sulfate proteoglycan metabolic process	ISO Inferred from Sequence Orthology more info
involved_in innervation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in kidney development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within liver regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endothelin production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelin production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial growth factor production	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of vascular endothelial growth factor production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of hepatocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sulfur compound metabolic process	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi stack	IEA Inferred from Electronic Annotation more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: extracellular sulfatase Sulf-2

Names: N-acetylglucosamine-6-sulfatase; arylsulfatase

NP_001239507.1

EC 3.1.6.1

EC 3.1.6.14

NP_001239508.1

EC 3.1.6.1

EC 3.1.6.14

NP_001342548.1

EC 3.1.6.1

EC 3.1.6.14

NP_082348.2

EC 3.1.6.1

EC 3.1.6.14

XP_006500272.1

EC 3.1.6.1

EC 3.1.6.14

XP_006500274.1

EC 3.1.6.1

EC 3.1.6.14

XP_030107960.1

EC 3.1.6.1

EC 3.1.6.14

XP_030107961.1

EC 3.1.6.1

EC 3.1.6.14

XP_036018478.1

EC 3.1.6.1

EC 3.1.6.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252578.1 → NP_001239507.1 extracellular sulfatase Sulf-2 isoform 1 precursor

See identical proteins and their annotated locations for NP_001239507.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 4 all encode the same isoform (1).

Source sequence(s)

AL589873

Consensus CDS

CCDS17086.1

UniProtKB/Swiss-Prot

B2RUD5, Q3TNM3, Q8BM68, Q8BUZ4, Q8BX28, Q8BZ51, Q8C169, Q8CFG0, Q9D8E2

UniProtKB/TrEMBL

Q6ZPV3

Related

ENSMUSP00000085405.4, ENSMUST00000088086.4

Conserved Domains (3) summary

cd16147
Location:43 → 385

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

pfam12548
Location:533 → 666

DUF3740; Sulfatase protein

cl23718
Location:754 → 803

ALP_like; alkaline phosphatases and sulfatases
NM_001252579.1 → NP_001239508.1 extracellular sulfatase Sulf-2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate upstream start codon compared to variant 1. The encoded isoform (2) is longer and has a distinct N-terminus compared to isoform 1.

Source sequence(s)

AK034712, AL589873, CF736722

UniProtKB/TrEMBL

Q6ZPV3

Conserved Domains (4) summary

COG3119
Location:76 → 420

AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]

pfam12548
Location:573 → 699

DUF3740; Sulfatase protein

cd16147
Location:76 → 418

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

cl23718
Location:787 → 836

ALP_like; alkaline phosphatases and sulfatases
NM_001355619.1 → NP_001342548.1 extracellular sulfatase Sulf-2 isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 all encode the same isoform (1).

Source sequence(s)

AL589873

Consensus CDS

CCDS17086.1

UniProtKB/Swiss-Prot

B2RUD5, Q3TNM3, Q8BM68, Q8BUZ4, Q8BX28, Q8BZ51, Q8C169, Q8CFG0, Q9D8E2

UniProtKB/TrEMBL

Q6ZPV3

Conserved Domains (3) summary

cd16147
Location:43 → 385

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

pfam12548
Location:533 → 666

DUF3740; Sulfatase protein

cl23718
Location:754 → 803

ALP_like; alkaline phosphatases and sulfatases
NM_028072.5 → NP_082348.2 extracellular sulfatase Sulf-2 isoform 1 precursor

See identical proteins and their annotated locations for NP_082348.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 all encode the same isoform (1).

Source sequence(s)

AK036685, AL589873, CF736722

Consensus CDS

CCDS17086.1

UniProtKB/Swiss-Prot

B2RUD5, Q3TNM3, Q8BM68, Q8BUZ4, Q8BX28, Q8BZ51, Q8C169, Q8CFG0, Q9D8E2

UniProtKB/TrEMBL

Q6ZPV3

Related

ENSMUSP00000104872.3, ENSMUST00000109249.9

Conserved Domains (3) summary

cd16147
Location:43 → 385

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

pfam12548
Location:533 → 666

DUF3740; Sulfatase protein

cl23718
Location:754 → 803

ALP_like; alkaline phosphatases and sulfatases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

165915819..165997603 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006500209.5 → XP_006500272.1 extracellular sulfatase Sulf-2 isoform X1

See identical proteins and their annotated locations for XP_006500272.1

UniProtKB/Swiss-Prot

B2RUD5, Q3TNM3, Q8BM68, Q8BUZ4, Q8BX28, Q8BZ51, Q8C169, Q8CFG0, Q9D8E2

UniProtKB/TrEMBL

Q6ZPV3

Conserved Domains (3) summary

cd16147
Location:43 → 385

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

pfam12548
Location:533 → 666

DUF3740; Sulfatase protein

cl23718
Location:754 → 803

ALP_like; alkaline phosphatases and sulfatases
XM_006500211.4 → XP_006500274.1 extracellular sulfatase Sulf-2 isoform X1

See identical proteins and their annotated locations for XP_006500274.1

UniProtKB/Swiss-Prot

B2RUD5, Q3TNM3, Q8BM68, Q8BUZ4, Q8BX28, Q8BZ51, Q8C169, Q8CFG0, Q9D8E2

UniProtKB/TrEMBL

Q6ZPV3

Conserved Domains (3) summary

cd16147
Location:43 → 385

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

pfam12548
Location:533 → 666

DUF3740; Sulfatase protein

cl23718
Location:754 → 803

ALP_like; alkaline phosphatases and sulfatases
XM_030252100.1 → XP_030107960.1 extracellular sulfatase Sulf-2 isoform X1

UniProtKB/Swiss-Prot

B2RUD5, Q3TNM3, Q8BM68, Q8BUZ4, Q8BX28, Q8BZ51, Q8C169, Q8CFG0, Q9D8E2

UniProtKB/TrEMBL

Q6ZPV3

Conserved Domains (3) summary

cd16147
Location:43 → 385

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

pfam12548
Location:533 → 666

DUF3740; Sulfatase protein

cl23718
Location:754 → 803

ALP_like; alkaline phosphatases and sulfatases
XM_036162585.1 → XP_036018478.1 extracellular sulfatase Sulf-2 isoform X1

UniProtKB/Swiss-Prot

B2RUD5, Q3TNM3, Q8BM68, Q8BUZ4, Q8BX28, Q8BZ51, Q8C169, Q8CFG0, Q9D8E2

UniProtKB/TrEMBL

Q6ZPV3

Conserved Domains (3) summary

cd16147
Location:43 → 385

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

pfam12548
Location:533 → 666

DUF3740; Sulfatase protein

cl23718
Location:754 → 803

ALP_like; alkaline phosphatases and sulfatases
XM_030252101.1 → XP_030107961.1 extracellular sulfatase Sulf-2 isoform X1

UniProtKB/Swiss-Prot

B2RUD5, Q3TNM3, Q8BM68, Q8BUZ4, Q8BX28, Q8BZ51, Q8C169, Q8CFG0, Q9D8E2

UniProtKB/TrEMBL

Q6ZPV3

Conserved Domains (3) summary

cd16147
Location:43 → 385

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

pfam12548
Location:533 → 666

DUF3740; Sulfatase protein

cl23718
Location:754 → 803

ALP_like; alkaline phosphatases and sulfatases