Med1 mediator complex subunit 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Med1provided by MGI
Official Full Name: mediator complex subunit 1provided by MGI
Primary source: MGI:MGI:1100846
See related: Ensembl:ENSMUSG00000018160 AllianceGenome:MGI:1100846
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PBP; Pparbp; TRIP-2; CRSP210; DRIP205; TRAP220; l11Jus15
Summary: Enables several functions, including nuclear receptor binding activity; promoter-specific chromatin binding activity; and transcription coregulator activity. Involved in several processes, including camera-type eye development; circulatory system development; and myeloid cell development. Acts upstream of or within several processes, including hemopoiesis; mammary gland development; and regulation of signal transduction. Located in nucleus. Part of mediator complex. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system gland; and lung. Used to study congestive heart failure and dilated cardiomyopathy. Orthologous to human MED1 (mediator complex subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 9.6), CNS E11.5 (RPKM 7.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 61.75 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (98042980..98084121, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (98152154..98193313, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mediator complex subunit 1 architects a tumorigenic Treg cell program independent of inflammation.
Title: Mediator complex subunit 1 architects a tumorigenic Treg cell program independent of inflammation.
Effect of Med1 on T cell development and CD4[+] T cell differentiation in immune response.
Title: Effect of Med1 on T cell development and CD4(+) T cell differentiation in immune response.
Mediator 1 ablation induces enamel-to-hair lineage conversion in mice through enhancer dynamics.
Title: Mediator 1 ablation induces enamel-to-hair lineage conversion in mice through enhancer dynamics.
Mediator1 involved in functional integration of Smad3 and Notch1 promoting enamel mineralization.
Title: Mediator1 involved in functional integration of Smad3 and Notch1 promoting enamel mineralization.
MED1 Ablation Promotes Oral Mucosal Wound Healing via JNK Signaling Pathway.
Title: MED1 Ablation Promotes Oral Mucosal Wound Healing via JNK Signaling Pathway.
MED1 Regulates BMP/TGF-beta in Endothelium: Implication for Pulmonary Hypertension.
Title: MED1 Regulates BMP/TGF-β in Endothelium: Implication for Pulmonary Hypertension.
Med1 Controls Effector CD8(+) T Cell Differentiation and Survival through C/EBPbeta-Mediated Transcriptional Control of T-bet.
Title: Med1 Controls Effector CD8(+) T Cell Differentiation and Survival through C/EBPβ-Mediated Transcriptional Control of T-bet.
MED1 Deficiency in Macrophages Aggravates Isoproterenol-Induced Cardiac Fibrosis in Mice.
Title: MED1 Deficiency in Macrophages Aggravates Isoproterenol-Induced Cardiac Fibrosis in Mice.
MED1 mediator subunit is a key regulator of hepatic autophagy and lipid metabolism.
Title: MED1 mediator subunit is a key regulator of hepatic autophagy and lipid metabolism.
MED1 Deficiency in Macrophages Accelerates Intimal Hyperplasia via ROS Generation and Inflammation.
Title: MED1 Deficiency in Macrophages Accelerates Intimal Hyperplasia via ROS Generation and Inflammation.

Submit: New GeneRIF Correction See all GeneRIFs (69)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (11) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH64892 (e-PCR)
- UniSTS:38518

AI480703 (e-PCR)
- UniSTS:164481

NoName (e-PCR)
- UniSTS:236727

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables LBD domain binding	IEA Inferred from Electronic Annotation more info
enables LBD domain binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables chromatin DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables general transcription initiation factor binding	IEA Inferred from Electronic Annotation more info
enables general transcription initiation factor binding	ISO Inferred from Sequence Orthology more info
enables histone acetyltransferase binding	IEA Inferred from Electronic Annotation more info
enables histone acetyltransferase binding	ISO Inferred from Sequence Orthology more info
enables nuclear estrogen receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info
enables nuclear receptor coactivator activity	ISS Inferred from Sequence or Structural Similarity more info
enables nuclear retinoic acid receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear retinoic acid receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear retinoic acid receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear thyroid hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear thyroid hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear thyroid hormone receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables nuclear vitamin D receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear vitamin D receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear vitamin D receptor binding	ISO Inferred from Sequence Orthology more info
enables peroxisome proliferator activated receptor binding	IEA Inferred from Electronic Annotation more info
enables peroxisome proliferator activated receptor binding	ISO Inferred from Sequence Orthology more info
enables promoter-specific chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	TAS Traceable Author Statement more info	PubMed
enables transcription coactivator binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator binding	ISO Inferred from Sequence Orthology more info
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coregulator activity	ISO Inferred from Sequence Orthology more info
enables transcription coregulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables transcription corepressor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
contributes_to ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of G0 to G1 transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in RNA polymerase II preinitiation complex assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in androgen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in androgen biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within animal organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within animal organ regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to epidermal growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to epidermal growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to hepatocyte growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to steroid hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to thyroid hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to thyroid hormone stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to thyroid hormone stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic heart tube development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic hindlimb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic placenta development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within enucleate erythrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cell proliferation involved in mammary gland duct elongation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within erythrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in erythrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fat cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in keratinocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within lactation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lens development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mammary gland branching involved in pregnancy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mammary gland branching involved in thelarche	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mammary gland epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in megakaryocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of keratinocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear receptor-mediated steroid hormone signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in nuclear receptor-mediated steroid hormone signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within peroxisome proliferator activated receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of G0 to G1 transition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of erythrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of hepatocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of intracellular estrogen receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of keratinocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription elongation by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of transcription initiation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription initiation by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription initiation by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of type II interferon-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in regulation of RNA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of RNA biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of vitamin D receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinal pigment epithelium development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within thyroid hormone generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thyroid hormone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in thyroid hormone receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within transcription by RNA polymerase II	IC Inferred by Curator more info	PubMed
involved_in transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed
involved_in ventricular trabecula myocardium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IEA Inferred from Electronic Annotation more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
part_of core mediator complex	ISO Inferred from Sequence Orthology more info
part_of mediator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mediator complex	IDA Inferred from Direct Assay more info	PubMed
part_of mediator complex	ISO Inferred from Sequence Orthology more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-DNA complex	IEA Inferred from Electronic Annotation more info
part_of protein-DNA complex	ISO Inferred from Sequence Orthology more info
part_of ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mediator of RNA polymerase II transcription subunit 1

Names: PPAR-binding protein; Ppar binding protein; TR-interacting protein 2; peroxisome proliferator-activated receptor-binding protein; thyroid hormone receptor-associated protein complex 220 kDa component; thyroid receptor-interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080118.2 → NP_001073587.1 mediator of RNA polymerase II transcription subunit 1 isoform 3

See identical proteins and their annotated locations for NP_001073587.1

Status: VALIDATED

Source sequence(s)

AL591205

Consensus CDS

CCDS36300.1

UniProtKB/Swiss-Prot

A2A526, A2A528, O88323, Q3UHV0, Q6AXD5, Q8BW37, Q8BX19, Q8VDQ7, Q925J9, Q925K0

Related

ENSMUSP00000103169.3, ENSMUST00000107545.9

Conserved Domains (1) summary

pfam10744
Location:60 → 426

Med1; Mediator of RNA polymerase II transcription subunit 1
NM_001361950.2 → NP_001348879.1 mediator of RNA polymerase II transcription subunit 1 isoform 4

Status: VALIDATED

Source sequence(s)

AL591205

Consensus CDS

CCDS88244.1

UniProtKB/TrEMBL

B1AQH6

Related

ENSMUSP00000090411.6, ENSMUST00000092735.12

Conserved Domains (1) summary

pfam10744
Location:60 → 426

Med1; Mediator of RNA polymerase II transcription subunit 1
NM_001361951.2 → NP_001348880.1 mediator of RNA polymerase II transcription subunit 1 isoform 5

Status: VALIDATED

Source sequence(s)

AL591205

Conserved Domains (1) summary

pfam10744
Location:60 → 426

Med1; Mediator of RNA polymerase II transcription subunit 1
NM_013634.3 → NP_038662.2 mediator of RNA polymerase II transcription subunit 1 isoform 1

See identical proteins and their annotated locations for NP_038662.2

Status: VALIDATED

Source sequence(s)

AL591205

Consensus CDS

CCDS25341.1

UniProtKB/Swiss-Prot

Q925J9

Related

ENSMUSP00000018304.6, ENSMUST00000018304.7

Conserved Domains (1) summary

pfam10744
Location:45 → 411

Med1; Mediator of RNA polymerase II transcription subunit 1
NM_134027.3 → NP_598788.2 mediator of RNA polymerase II transcription subunit 1 isoform 2

See identical proteins and their annotated locations for NP_598788.2

Status: VALIDATED

Source sequence(s)

AL591205

UniProtKB/Swiss-Prot

Q925J9

Conserved Domains (1) summary

pfam10744
Location:60 → 426

Med1; Mediator of RNA polymerase II transcription subunit 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

98042980..98084121 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532504.3 → XP_006532567.1 mediator of RNA polymerase II transcription subunit 1 isoform X1

Conserved Domains (1) summary

pfam10744
Location:60 → 426

Med1; Mediator of RNA polymerase II transcription subunit 1
XM_006532505.3 → XP_006532568.1 mediator of RNA polymerase II transcription subunit 1 isoform X2

Conserved Domains (1) summary

pfam10744
Location:60 → 426

Med1; Mediator of RNA polymerase II transcription subunit 1