Grip2 glutamate receptor interacting protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Grip2provided by MGI
Official Full Name: glutamate receptor interacting protein 2provided by MGI
Primary source: MGI:MGI:2681173
See related: Ensembl:ENSMUSG00000030098 AllianceGenome:MGI:2681173
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable glutamate receptor binding activity. Involved in neurotransmitter receptor transport, endosome to postsynaptic membrane and vesicle-mediated transport in synapse. Acts upstream of or within Notch signaling pathway; artery smooth muscle contraction; and positive regulation of blood pressure. Is active in glutamatergic synapse. Is expressed in diencephalon lateral wall mantle layer; olfactory cortex mantle layer; and tongue. Orthologous to human GRIP2 (glutamate receptor interacting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in frontal lobe adult (RPKM 10.3), CNS E18 (RPKM 10.0) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 D1; 6 40.8 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (91738433..91820884, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (91761452..91843954, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variants of innate CD8(+) T cells are associated with Grip2 and Klf15 genes.
Title: Variants of innate CD8(+) T cells are associated with Grip2 and Klf15 genes.
Results indicate that loss of Grip1/2 in cerebellar Purkinje cells contributes to increased repetitive self-grooming, a core autism behavior in mice
Title: Purkinje cell-specific Grip1/2 knockout mice show increased repetitive self-grooming and enhanced mGluR5 signaling in cerebellum.
Study performed social behavioral testing on neuron-specific Grip1/2-double knockout (DKO) and wild type (WT) mice and determined the expression profile of key signaling proteins in AMPAR, mGluR, mTOR, and GABA pathways in brain. Data Grip1/2-mediated AMPA signaling in regulating social behaviors and disturbance of glutamate- and GABA-signaling in specialized brain regions in autism-related social behavioral deficits.
Title: Mice lacking GRIP1/2 show increased social interactions and enhanced phosphorylation at GluA2-S880.
This study demonistrated that deletion of accumbal GRIP2 increases vulnerability to cue-induced cocaine relapse without altering the reinforcing properties of the drug or the response to natural rewards
Title: Disruption of glutamate receptor-interacting protein in nucleus accumbens enhances vulnerability to cocaine relapse.
Identify Grip2 and Notch3 target regulating myogenic response of cerebral vessels.
Title: Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature.
GRIP1 and 2 regulate activity-dependent AMPA receptor recycling via exocyst complex interactions.
Title: GRIP1 and 2 regulate activity-dependent AMPA receptor recycling via exocyst complex interactions.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Markers

RH136997 (e-PCR)
- UniSTS:219086

RH124443 (e-PCR)
- UniSTS:161265

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within artery smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane	IEP Inferred from Expression Pattern more info	PubMed
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of AMPA glutamate receptor clustering	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron maturation	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport in synapse	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle-mediated transport in synapse	IEP Inferred from Expression Pattern more info	PubMed
involved_in vesicle-mediated transport in synapse	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in neuron spine	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density, intracellular component	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutamate receptor-interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159507.2 → NP_001152979.1 glutamate receptor-interacting protein 2 isoform 1

See identical proteins and their annotated locations for NP_001152979.1

Status: VALIDATED

Source sequence(s)

AC162914

Consensus CDS

CCDS51852.1

UniProtKB/TrEMBL

E0CXS4, G3XA20

Related

ENSMUSP00000124709.2, ENSMUST00000162300.8

Conserved Domains (1) summary

cd00992
Location:657 → 737

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001411663.1 → NP_001398592.1 glutamate receptor-interacting protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC162914, AC168852

UniProtKB/TrEMBL

E0CXS4
NM_001411664.1 → NP_001398593.1 glutamate receptor-interacting protein 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC162914

UniProtKB/TrEMBL

E0CXS4

RNA

NR_177446.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC162914
NR_177447.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC162914

Related

ENSMUST00000162293.8
NR_177448.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC162914

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

91738433..91820884 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506103.4 → XP_006506166.1 glutamate receptor-interacting protein 2 isoform X2

UniProtKB/TrEMBL

E0CXS4

Conserved Domains (1) summary

cd00992
Location:664 → 744

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...