Rfng RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rfngprovided by MGI
Official Full Name: RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferaseprovided by MGI
Primary source: MGI:MGI:894275
See related: Ensembl:ENSMUSG00000025158 AllianceGenome:MGI:894275
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity. Involved in regulation of Notch signaling pathway. Acts upstream of or within positive regulation of Notch signaling pathway. Predicted to be located in Golgi membrane. Is expressed in several structures, including central nervous system; genitourinary system; limb; retina; and small intestine. Orthologous to human RFNG (RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in duodenum adult (RPKM 67.3), adrenal adult (RPKM 54.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 84.53 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (120671571..120675077, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (120780745..120784251, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fringe modifications at EGF8 and EGF12 enhanced Notch1 binding to and activation from Delta-like 1, while modifications at EGF6 and EGF36 (added by Manic and Lunatic but not Radical) inhibited Notch1 activation from Jagged1.
Title: Deciphering the Fringe-Mediated Notch Code: Identification of Activating and Inhibiting Sites Allowing Discrimination between Ligands.
each Fringe contributes to T and B cell development, and Fringe is required for optimal in vitro stimulation of T and B cells.
Title: Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development.
No obvious synergistic defects in mice in the absence of two, or all three, fringe genes during development of the axial skeleton, limbs, hindbrain, and cranial nerves.
Title: Manic fringe is not required for embryonic development, and fringe family members do not exhibit redundant functions in the axial skeleton, limb, or hindbrain.
Jag1/fringe genes (Lfng, Rfng, and Mfng) may regulate postnatal bile duct growth and remodeling, and serve as candidate modifiers of the hepatic phenotype in Alagille syndrome.
Title: Bile duct proliferation in Jag1/fringe heterozygous mice identifies candidate modifiers of the Alagille syndrome hepatic phenotype.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in pattern specification process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: beta-1,3-N-acetylglucosaminyltransferase radical fringe

Names: O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; radical fringe gene homolog

NP_033079.1

EC 2.4.1.222

XP_006532669.1

EC 2.4.1.222

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009053.2 → NP_033079.1 beta-1,3-N-acetylglucosaminyltransferase radical fringe

See identical proteins and their annotated locations for NP_033079.1

Status: VALIDATED

Source sequence(s)

BC066023

Consensus CDS

CCDS25757.1

UniProtKB/Swiss-Prot

B1ATU3, O09009

Related

ENSMUSP00000026156.8, ENSMUST00000026156.8

Conserved Domains (1) summary

pfam02434
Location:56 → 306

Fringe; Fringe-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

120671571..120675077 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532606.3 → XP_006532669.1 beta-1,3-N-acetylglucosaminyltransferase radical fringe isoform X1

Conserved Domains (1) summary

pfam02434
Location:56 → 249

Fringe; Fringe-like