FRE1 ferric/cupric-chelate reductase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: FRE1
Official Full Name: ferric/cupric-chelate reductase
Primary source: SGD:S000004204
Locus tag: YLR214W
See related: AllianceGenome:SGD:S000004204; FungiDB:YLR214W; VEuPathDB:YLR214W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables ferric-chelate reductase activity. Involved in copper ion import and iron ion transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See FRE1 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (568567..570627)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data support the conclusion that FRE1 mRNA is immune to nonsense-mediated mRNA decay-mediated degradation under both inducing and non-inducing conditions.
Title: Nonsense-mediated mRNA decay of the ferric and cupric reductase mRNAs FRE1 and FRE2 in Saccharomyces cerevisiae.
Inhibition of Fre1 by nitric oxide also inhibited yeast growth in low-iron medium.
Title: Inhibition of the yeast metal reductase heme protein fre1 by nitric oxide (NO): a model for inhibition of NADPH oxidase by NO.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ferric-chelate reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables ferric-chelate reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ferric-chelate reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables ferric-chelate reductase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in copper ion import	IBA Inferred from Biological aspect of Ancestor more info
involved_in copper ion import	IDA Inferred from Direct Assay more info	PubMed
involved_in copper ion transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular iron ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in iron ion transport	IEA Inferred from Electronic Annotation more info
involved_in transition metal ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ferric/cupric-chelate reductase

NP_013315.1

EC 1.16.1.9

Ferric reductase and cupric reductase; reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

568567..570627

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182101.1 → NP_013315.1 TPA: ferric/cupric-chelate reductase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013315.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VYL5, P32791

UniProtKB/TrEMBL

A7A1A2, C8ZDH8, G2WJ44, N1P1C4

Conserved Domains (3) summary

cd06186
Location:414 → 684

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

pfam01794
Location:261 → 374

Ferric_reduct; Ferric reductase like transmembrane component

pfam05730
Location:26 → 84

CFEM; CFEM domain