Tram1 translocating chain-associating membrane protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tram1provided by MGI
Official Full Name: translocating chain-associating membrane protein 1provided by MGI
Primary source: MGI:MGI:1919515
See related: Ensembl:ENSMUSG00000025935 AllianceGenome:MGI:1919515
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TRAMP; 1810049E02Rik
Summary: This gene encodes a multi-pass transmembrane protein of the endoplasmic reticulum (ER). It is involved in the process of cotranslational translocation of secretory proteins into the ER. [provided by RefSeq, Dec 2014]
Expression: Ubiquitous expression in placenta adult (RPKM 47.6), testis adult (RPKM 32.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 A3; 1 4.18 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (13634917..13660134, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (13564693..13589910, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRAM1 plays an essential role in the M1 polarization of microglia. TRAM1 increases M1-related gene expression.
Title: TRAM1 Promotes Microglia M1 Polarization.
These data indicate that TRAM is recognized by the signal recognition particle and translocon components, and suggest a membrane topology with eight transmembrane segments, including several poorly hydrophobic segments.
Title: Membrane insertion and topology of the translocating chain-associating membrane protein (TRAM).

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation	IEA Inferred from Electronic Annotation more info
involved_in cotranslational protein targeting to membrane	ISO Inferred from Sequence Orthology more info
involved_in cotranslational protein targeting to membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein insertion into ER membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein insertion into ER membrane	ISO Inferred from Sequence Orthology more info
involved_in protein insertion into ER membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to unfolded protein	ISO Inferred from Sequence Orthology more info
involved_in response to unfolded protein	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: translocating chain-associated membrane protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028173.5 → NP_082449.1 translocating chain-associated membrane protein 1

See identical proteins and their annotated locations for NP_082449.1

Status: REVIEWED

Source sequence(s)

AC157769

Consensus CDS

CCDS14822.1

UniProtKB/Swiss-Prot

Q91V04

UniProtKB/TrEMBL

Q3UAT2, Q3UQ93, Q4FK14

Related

ENSMUSP00000027068.5, ENSMUST00000027068.11

Conserved Domains (2) summary

smart00724
Location:117 → 326

TLC; TRAM, LAG1 and CLN8 homology domains

pfam08390
Location:47 → 115

TRAM1; TRAM1-like protein