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    Krt35 keratin 35 [ Mus musculus (house mouse) ]

    Gene ID: 53617, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Krt35provided by MGI
    Official Full Name
    keratin 35provided by MGI
    Primary source
    MGI:MGI:1858899
    See related
    Ensembl:ENSMUSG00000048013 AllianceGenome:MGI:1858899
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ha5; Krtha5; Krt1-24
    Summary
    Predicted to enable structural molecule activity. Predicted to be involved in epithelial cell differentiation and intermediate filament organization. Predicted to be located in intermediate filament. Predicted to be active in cytoskeleton. Is expressed in filiform papillae; skin; and tongue. Orthologous to human KRT35 (keratin 35). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Krt35 in Genome Data Viewer
    Location:
    11 D; 11 63.4 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (99983018..99987050, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100092192..100096224, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene keratin 31 Neighboring gene predicted gene 11571 Neighboring gene keratin 32 Neighboring gene STARR-seq mESC enhancer starr_30712 Neighboring gene keratin 36 Neighboring gene keratin 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transcriptional activation of a subset of hair keratin genes by the NF-kappaB effector p65/RelA. Gilon M, et al. Differentiation, 2008 May. PMID 18021261
    2. Pax9 is required for filiform papilla development and suppresses skin-specific differentiation of the mammalian tongue epithelium. Jonker L, et al. Mech Dev, 2004 Nov. PMID 15454262
    3. Dlx3 is a crucial regulator of hair follicle differentiation and cycling. Hwang J, et al. Development, 2008 Sep. PMID 18684741, Free PMC Article
    4. Bcl11b/Ctip2 is required for development of lingual papillae in mice. Nishiguchi Y, et al. Dev Biol, 2016 Aug 1. PMID 27287879
    5. Deletion of the epidermis derived laminin γ1 chain leads to defects in the regulation of late hair morphogenesis. Fleger-Weckmann A, et al. Matrix Biol, 2016 Dec. PMID 27234308

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transfected human p65 induces transcriptional activation of mouse Ha5.
      Title: Transcriptional activation of a subset of hair keratin genes by the NF-kappaB effector p65/RelA.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in epithelial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    keratin, type I cuticular Ha5
    Names
    K35
    hair keratin acidic 5
    hair keratin, type I Ha5
    keratin complex 1, acidic, gene 24
    keratin complex 1, gene 24
    keratin, hair, acidic, 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016880.2 → NP_058576.2  keratin, type I cuticular Ha5

      See identical proteins and their annotated locations for NP_058576.2

      Status: VALIDATED

      Source sequence(s)
      BC100542
      Consensus CDS
      CCDS25407.2
      UniProtKB/Swiss-Prot
      B2RU48, Q497I4, Q9Z2T8
      Related
      ENSMUSP00000099416.4, ENSMUST00000103127.4
      Conserved Domains (3) summary
      pfam00038
      Location:96 → 407
      Filament; Intermediate filament protein
      pfam16888
      Location:305 → 408
      DUF5082; Domain of unknown function (DUF5082)
      cl00459
      Location:192 → 334
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      99983018..99987050 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q497I4.1 GenPept UniProtKB/Swiss-Prot:Q497I4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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