Ankrd17 ankyrin repeat domain 17 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ankrd17provided by MGI
Official Full Name: ankyrin repeat domain 17provided by MGI
Primary source: MGI:MGI:1932101
See related: Ensembl:ENSMUSG00000055204 AllianceGenome:MGI:1932101
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Foe; Gtar; Mask; mKIAA0697; A930008M01; 4933425K22Rik; A130069E23Rik
Summary: This gene encodes a protein with ankyrin repeats, which are associated with protein-protein interactions. Studies suggest that this protein is involved in liver development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in placenta adult (RPKM 15.9), whole brain E14.5 (RPKM 11.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 E1; 5 44.32 cM

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (90375025..90517133, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (90227166..90368693, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ANKRD17 expression was predominantly restricted to pachytene spermatocytes and round spermatids. ANKRD17 was diffusely distributed throughout the nucleus of pachytene cells but excluded from the XY body and other heterochromatic regions.
Title: Experimental validation of Ankrd17 and Anapc10, two novel meiotic genes predicted by computational models in mice.
Data demonstrate the indispensability of Ankrd17 functioning for vascular maturation during early development.
Title: Ankrd17, an ubiquitously expressed ankyrin factor, is essential for the vascular integrity during embryogenesis.
Ankrd17 is an important downstream effector of cyclin E/Cdk2 and positively regulates G(1)/S transition
Title: Identification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17.
there are overlapping reading frames in the mouse and human genes for 4E-BP3 and MASK
Title: Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU017193 (e-PCR)
- UniSTS:179200

G34499 (e-PCR)
- UniSTS:50180

D11Bhm20 (e-PCR), detects polymorphism
- UniSTS:141619

RH127459 (e-PCR)
- UniSTS:210769

RH124614 (e-PCR)
- UniSTS:161436

AU040470 (e-PCR)
- UniSTS:159391

RH124407 (e-PCR)
- UniSTS:161229

NoName (e-PCR)
- UniSTS:235214

NoName (e-PCR)
- UniSTS:235215

Ankrd17 (e-PCR), detects polymorphism
- UniSTS:468187

Ankrd17 (e-PCR), detects polymorphism
- UniSTS:468188

Ankrd17 (e-PCR), detects polymorphism
- UniSTS:468189

D5Wsu152e (e-PCR), detects polymorphism
- UniSTS:142569

RH126512 (e-PCR)
- UniSTS:209655

RH126622 (e-PCR)
- UniSTS:167423

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood vessel maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within endoderm development	TAS Traceable Author Statement more info	PubMed
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of smooth muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of MDA-5 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MDA-5 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of RIG-I signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of RIG-I signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA replication	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in male germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ankyrin repeat domain-containing protein 17

Names: ankyrin repeat domain containing protein FOE; gene trap ankyrin repeat protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401341.1 → NP_001388270.1 ankyrin repeat domain-containing protein 17 isoform c

Status: REVIEWED

Source sequence(s)

AC117578, AC162171
NM_030886.2 → NP_112148.2 ankyrin repeat domain-containing protein 17 isoform a

See identical proteins and their annotated locations for NP_112148.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AC140220, AC162171

Consensus CDS

CCDS57354.1

UniProtKB/Swiss-Prot

Q3TV99, Q5F4T7, Q6PG69, Q6ZQ66, Q8CHT4, Q99NH0

UniProtKB/TrEMBL

E9Q804

Related

ENSMUSP00000014421.9, ENSMUST00000014421.15

Conserved Domains (9) summary

TIGR02926
Location:801 → 877

AhaH; ATP synthase archaeal, H subunit

smart00248
Location:1078 → 1106

ANK; ankyrin repeats

COG0666
Location:1042 → 1268

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00105
Location:1723 → 1785

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd00204
Location:392 → 516

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam03938
Location:790 → 889

OmpH; Outer membrane protein (OmpH-like)

pfam12796
Location:301 → 390

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:1349 → 1402

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:431 → 460

ANK; ANK repeat [structural motif]
NM_198010.2 → NP_932127.2 ankyrin repeat domain-containing protein 17 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AC140220, AC162171

Consensus CDS

CCDS57353.1

UniProtKB/TrEMBL

E9Q804, E9QKG6

Related

ENSMUSP00000080587.7, ENSMUST00000081914.13

Conserved Domains (6) summary

COG0666
Location:791 → 1017

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00105
Location:1472 → 1534

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd00204
Location:392 → 516

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:301 → 390

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:1098 → 1151

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:431 → 460

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

90375025..90517133 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006535289.5 → XP_006535352.3 ankyrin repeat domain-containing protein 17 isoform X3

UniProtKB/TrEMBL

E9Q804

Conserved Domains (7) summary

smart00248
Location:1117 → 1145

ANK; ankyrin repeats

PHA03095
Location:1132 → 1395

PHA03095; ankyrin-like protein; Provisional

PHA03247
Location:2147 → 2483

PHA03247; large tegument protein UL36; Provisional

cd00105
Location:1762 → 1824

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

sd00045
Location:722 → 751

ANK; ANK repeat [structural motif]

pfam03154
Location:1931 → 2359

Atrophin-1; Atrophin-1 family

pfam12796
Location:855 → 946

Ank_2; Ankyrin repeats (3 copies)
XM_006535287.5 → XP_006535350.3 ankyrin repeat domain-containing protein 17 isoform X1

UniProtKB/TrEMBL

E9Q804

Related

ENSMUSP00000128960.4, ENSMUST00000168058.7

Conserved Domains (8) summary

PHA03095
Location:1383 → 1646

PHA03095; ankyrin-like protein; Provisional

PHA03247
Location:2398 → 2734

PHA03247; large tegument protein UL36; Provisional

cd00105
Location:2013 → 2075

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

sd00045
Location:722 → 751

ANK; ANK repeat [structural motif]

pfam03154
Location:2182 → 2610

Atrophin-1; Atrophin-1 family

pfam12796
Location:855 → 946

Ank_2; Ankyrin repeats (3 copies)

pfam03938
Location:1081 → 1180

OmpH; Outer membrane protein (OmpH-like)

cl39094
Location:1361 → 1399

Ank_2; Ankyrin repeats (3 copies)
XM_006535288.5 → XP_006535351.3 ankyrin repeat domain-containing protein 17 isoform X2

UniProtKB/TrEMBL

E9Q804

Conserved Domains (8) summary

PHA03095
Location:1384 → 1647

PHA03095; ankyrin-like protein; Provisional

PHA03247
Location:2399 → 2735

PHA03247; large tegument protein UL36; Provisional

cd00105
Location:2014 → 2076

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

sd00045
Location:722 → 751

ANK; ANK repeat [structural motif]

pfam03154
Location:2183 → 2611

Atrophin-1; Atrophin-1 family

pfam12796
Location:855 → 946

Ank_2; Ankyrin repeats (3 copies)

pfam03938
Location:1081 → 1180

OmpH; Outer membrane protein (OmpH-like)

cl39094
Location:1362 → 1400

Ank_2; Ankyrin repeats (3 copies)
XM_006535290.4 → XP_006535353.1 ankyrin repeat domain-containing protein 17 isoform X5

UniProtKB/TrEMBL

A0A0G2JDZ9, E9Q804

Related

ENSMUSP00000142575.2, ENSMUST00000197021.2

Conserved Domains (7) summary

PHA03095
Location:984 → 1247

PHA03095; ankyrin-like protein; Provisional

PHA03247
Location:1953 → 2335

PHA03247; large tegument protein UL36; Provisional

cd00105
Location:1614 → 1676

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

sd00045
Location:322 → 351

ANK; ANK repeat [structural motif]

pfam12796
Location:455 → 546

Ank_2; Ankyrin repeats (3 copies)

pfam03938
Location:681 → 780

OmpH; Outer membrane protein (OmpH-like)

cl39094
Location:962 → 1000

Ank_2; Ankyrin repeats (3 copies)
XM_036165629.1 → XP_036021522.1 ankyrin repeat domain-containing protein 17 isoform X6

UniProtKB/TrEMBL

E9Q804

Conserved Domains (7) summary

PHA03095
Location:967 → 1230

PHA03095; ankyrin-like protein; Provisional

PHA03247
Location:1936 → 2318

PHA03247; large tegument protein UL36; Provisional

sd00045
Location:305 → 334

ANK; ANK repeat [structural motif]

pfam03938
Location:664 → 763

OmpH; Outer membrane protein (OmpH-like)

pfam12796
Location:438 → 529

Ank_2; Ankyrin repeats (3 copies)

cd22502
Location:1596 → 1666

KH-I_ANKRD17; type I K homology (KH) RNA-binding domain found in ankyrin repeat domain-containing protein 17 (ANKRD17) and similar proteins

cl39094
Location:945 → 983

Ank_2; Ankyrin repeats (3 copies)
XM_011249595.4 → XP_011247897.3 ankyrin repeat domain-containing protein 17 isoform X4

UniProtKB/TrEMBL

E9Q804

Conserved Domains (8) summary

smart00248
Location:1369 → 1397

ANK; ankyrin repeats

PHA03095
Location:1384 → 1647

PHA03095; ankyrin-like protein; Provisional

PHA03247
Location:2142 → 2510

PHA03247; large tegument protein UL36; Provisional

cd00105
Location:2014 → 2076

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

sd00045
Location:722 → 751

ANK; ANK repeat [structural motif]

pfam03154
Location:2352 → 2606

Atrophin-1; Atrophin-1 family

pfam12796
Location:855 → 946

Ank_2; Ankyrin repeats (3 copies)

pfam03938
Location:1081 → 1180

OmpH; Outer membrane protein (OmpH-like)