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    TXLNA taxilin alpha [ Homo sapiens (human) ]

    Gene ID: 200081, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TXLNAprovided by HGNC
    Official Full Name
    taxilin alphaprovided by HGNC
    Primary source
    HGNC:HGNC:30685
    See related
    Ensembl:ENSG00000084652 MIM:608676; AllianceGenome:HGNC:30685
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IL14; TXLN; IL-14
    Summary
    Predicted to enable syntaxin binding activity. Predicted to be involved in exocytosis. Predicted to act upstream of or within B cell activation. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 17.8), skin (RPKM 14.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TXLNA in Genome Data Viewer
    Location:
    1p35.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (32179675..32198285)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (32037572..32056187)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (32645276..32663886)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene transmembrane protein 39B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32557367-32557892 Neighboring gene microRNA 5585 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:32573351-32573869 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:32573870-32574387 Neighboring gene Sharpr-MPRA regulatory region 5670 Neighboring gene karyopherin subunit alpha 6 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:32644454-32645213 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:32645214-32645972 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32664855-32665413 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32665414-32665971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 672 Neighboring gene H3K4me1 hESC enhancers GRCh37_chr1:32666522-32667041 and GRCh37_chr1:32667042-32667562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32670259-32670760 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 675 Neighboring gene coiled-coil domain containing 28B Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:32681346-32682545 Neighboring gene doublecortin domain containing 2B Neighboring gene IQ motif containing C Neighboring gene transmembrane protein 234

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of a cDNA for a human high-molecular-weight B-cell growth factor. Ambrus JL Jr, et al. Proc Natl Acad Sci U S A, 1993 Jul 1. PMID 8327514, Free PMC Article
    2. Identification of a cDNA for a human high molecular-weight B-cell growth factor. Ambrus JL Jr, et al. Proc Natl Acad Sci U S A, 1996 Jul 23. PMID 8755619, Free PMC Article
    3. High TXLNA Expression Predicts Favourable Outcome for Pancreatic Adenocarcinoma Patients. Lv S, et al. Biomed Res Int, 2020. PMID 32185195, Free PMC Article
    4. Characterization of α-taxilin as a novel factor controlling the release of hepatitis C virus. Elgner F, et al. Biochem J, 2016 Jan 15. PMID 26527738
    5. Identification of α-taxilin as an essential factor for the life cycle of hepatitis B virus. Hoffmann J, et al. J Hepatol, 2013 Nov. PMID 23816704

    See all (114) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. alpha-/gamma-Taxilin are required for centriolar subdistal appendage assembly and microtubule organization.
      Title: α-/γ-Taxilin are required for centriolar subdistal appendage assembly and microtubule organization.
    2. High TXLNA Expression Predicts Favourable Outcome for Pancreatic Adenocarcinoma Patients.
      Title: High TXLNA Expression Predicts Favourable Outcome for Pancreatic Adenocarcinoma Patients.
    3. intrathyroidal production of IL-14 and IL-16 associated with the pathogenesis of autoimmune thyroid disease
      Title: IL-14 and IL-16 are expressed in the thyroid of patients with either Graves' disease or Hashimoto's thyroiditis.
    4. Silencing of alpha-taxilin expression leads to increased release of infectious hepatitis C virus particles.
      Title: Characterization of α-taxilin as a novel factor controlling the release of hepatitis C virus.
    5. alpha-taxilin interacts with SNX4 and plays a role in the recycling pathway of TfnR.
      Title: α-Taxilin interacts with sorting nexin 4 and participates in the recycling pathway of transferrin receptor.
    6. alpha-taxilin plays an essential role for release of HBV-DNA containing particles.
      Title: Identification of α-taxilin as an essential factor for the life cycle of hepatitis B virus.
    7. Alpha-taxilin is localized on intracellular components in a syntaxin-independent manner and that the alpha-taxilin-containing intracellular components are associated with the microtubule cytoskeleton.
      Title: Interaction of α-taxilin localized on intracellular components with the microtubule cytoskeleton.
    8. Increased alpha-taxilin protein expression is associated with the metastatic and invasive potential of renal cell cancer.
      Title: Increased alpha-taxilin protein expression is associated with the metastatic and invasive potential of renal cell cancer.
    9. alpha-taxilin may be involved in cell proliferation of hepatocellular carcinoma(HCC), and its expression can be a marker of malignant potential of HCC.
      Title: Expression of α-taxilin in hepatocellular carcinoma correlates with growth activity and malignant potential of the tumor.
    10. analysis of a novel monoclonal antibody against interleukin-14alpha
      Title: Characteristics of a novel monoclonal antibody against interleukin-14alpha.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118870, MGC118871, DKFZp451J0118

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables syntaxin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in B cell activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane HDA PubMed 

    General protein information

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    Preferred Names
    alpha-taxilin
    Names
    interleukin 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001376857.1 → NP_001363786.1  alpha-taxilin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL049795
      Consensus CDS
      CCDS353.1
      UniProtKB/Swiss-Prot
      D3DPP6, P40222, Q5TFJ6, Q66K62, Q86T54, Q86T85, Q86T86, Q86Y86, Q86YW3, Q8N2Y3
      Related
      ENSP00000362711.1, ENST00000373609.1
      Conserved Domains (2) summary
      PRK07764
      Location:9 → 161
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      pfam09728
      Location:172 → 477
      Taxilin; Myosin-like coiled-coil protein

    2. NM_001376858.1 → NP_001363787.1  alpha-taxilin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL049795
      Conserved Domains (1) summary
      pfam09728
      Location:1 → 302
      Taxilin; Myosin-like coiled-coil protein

    3. NM_001376859.1 → NP_001363788.1  alpha-taxilin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL049795
      Conserved Domains (1) summary
      pfam09728
      Location:1 → 302
      Taxilin; Myosin-like coiled-coil protein

    4. NM_175852.4 → NP_787048.1  alpha-taxilin isoform 1

      See identical proteins and their annotated locations for NP_787048.1

      Status: VALIDATED

      Source sequence(s)
      AL049795, AL832338, BC029686, BC046565
      Consensus CDS
      CCDS353.1
      UniProtKB/Swiss-Prot
      D3DPP6, P40222, Q5TFJ6, Q66K62, Q86T54, Q86T85, Q86T86, Q86Y86, Q86YW3, Q8N2Y3
      Related
      ENSP00000362712.3, ENST00000373610.8
      Conserved Domains (2) summary
      PRK07764
      Location:9 → 161
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      pfam09728
      Location:172 → 477
      Taxilin; Myosin-like coiled-coil protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      32179675..32198285
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017000563.2 → XP_016856052.1  alpha-taxilin isoform X1

    2. XM_011540932.3 → XP_011539234.1  alpha-taxilin isoform X2

      See identical proteins and their annotated locations for XP_011539234.1

      Conserved Domains (1) summary
      pfam09728
      Location:40 → 318
      Taxilin; Myosin-like coiled-coil protein

    3. XM_017000561.2 → XP_016856050.1  alpha-taxilin isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      32037572..32056187
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334933.1 → XP_054190908.1  alpha-taxilin isoform X1

    2. XM_054334934.1 → XP_054190909.1  alpha-taxilin isoform X2

    3. XM_054334932.1 → XP_054190907.1  alpha-taxilin isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40222.3 GenPept UniProtKB/Swiss-Prot:P40222

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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