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    C11orf86 chromosome 11 open reading frame 86 [ Homo sapiens (human) ]

    Gene ID: 254439, updated on 10-Dec-2024

    Summary

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    Official Symbol
    C11orf86provided by HGNC
    Official Full Name
    chromosome 11 open reading frame 86provided by HGNC
    Primary source
    HGNC:HGNC:34442
    See related
    Ensembl:ENSG00000173237 AllianceGenome:HGNC:34442
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FACI
    Expression
    Biased expression in duodenum (RPKM 30.9), small intestine (RPKM 29.9) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See C11orf86 in Genome Data Viewer
    Location:
    11q13.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (66975304..66977009)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (66969804..66971509)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (66742775..66744480)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene pyruvate carboxylase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5060 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:66688620-66689560 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66690541-66691041 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:66691815-66692466 Neighboring gene RNA, U7 small nuclear 23 pseudogene Neighboring gene microRNA 3163 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5061 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3607 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5062 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3608 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:66743456-66743959 Neighboring gene Sharpr-MPRA regulatory region 11253 Neighboring gene uncharacterized LOC124902849 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:66769673-66770332 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:66788895-66790094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66791036-66791536 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66791537-66792037 Neighboring gene synaptotagmin 12 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5064 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66799719-66800558 Neighboring gene microRNA 6860

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. FACI Is a Novel CREB-H-Induced Protein That Inhibits Intestinal Lipid Absorption and Reverses Diet-Induced Obesity. Cheng Y, et al. Cell Mol Gastroenterol Hepatol, 2022. PMID 35093589, Free PMC Article
    2. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Psychiatric GWAS Consortium Bipolar Disorder Working Group. Nat Genet, 2011 Sep 18. PMID 21926972, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Homology

    Clone Names

    • FLJ22675

    General protein information

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    Preferred Names
    uncharacterized protein C11orf86
    Names
    fasting and CREB-H induced

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136485.3 → NP_001129957.1  uncharacterized protein C11orf86 isoform 2

      See identical proteins and their annotated locations for NP_001129957.1

      Status: VALIDATED

      Source sequence(s)
      AK026328, AP003176
      Consensus CDS
      CCDS44656.1
      UniProtKB/Swiss-Prot
      A6NJI1
      Related
      ENSP00000311479.4, ENST00000308963.4
      Conserved Domains (1) summary
      pfam15464
      Location:1 → 114
      DUF4633; Domain of unknown function (DUF4633)

    2. NM_001353554.2 → NP_001340483.1  uncharacterized protein C11orf86 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AK026328, AP003176, HY168701
      Consensus CDS
      CCDS91512.1
      UniProtKB/TrEMBL
      A0A804HHS3
      Related
      ENSP00000506734.1, ENST00000683896.1
      Conserved Domains (1) summary
      pfam15464
      Location:1 → 115
      DUF4633; Domain of unknown function (DUF4633)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      66975304..66977009
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      66969804..66971509
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NJI1.2 GenPept UniProtKB/Swiss-Prot:A6NJI1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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