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    Ints6 integrator complex subunit 6 [ Mus musculus (house mouse) ]

    Gene ID: 18130, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ints6provided by MGI
    Official Full Name
    integrator complex subunit 6provided by MGI
    Primary source
    MGI:MGI:1202397
    See related
    Ensembl:ENSMUSG00000035161 AllianceGenome:MGI:1202397
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HDB; DICE1; Ddx26; Notch2l; 2900075H24Rik
    Summary
    Predicted to be involved in snRNA 3'-end processing. Predicted to be located in actin cytoskeleton and nucleoplasm. Predicted to be part of integrator complex. Is expressed in neural retina and neural retinal epithelium. Orthologous to human INTS6 (integrator complex subunit 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 6.7), placenta adult (RPKM 5.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ints6 in Genome Data Viewer
    Location:
    14 D1; 14 33.23 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (62913774..62998617, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (62676325..62761163, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23816 Neighboring gene serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 Neighboring gene predicted gene, 25162 Neighboring gene 60S ribosomal protein L38 pseudogene Neighboring gene STARR-seq mESC enhancer starr_36903 Neighboring gene RIKEN cDNA 4931440J10 gene Neighboring gene STARR-positive B cell enhancer ABC_E756 Neighboring gene predicted gene, 35678 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7323 Neighboring gene predicted gene, 26536 Neighboring gene microRNA 8098 Neighboring gene WD repeat and FYVE domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DBI-1, a novel gene related to the notch family, modulates mitogenic response to insulin-like growth factor 1. Hoff HB 3rd, et al. Exp Cell Res, 1998 Feb 1. PMID 9473344
    2. Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. Lachke SA, et al. Science, 2011 Mar 25. PMID 21436445, Free PMC Article
    3. The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer. Vervoort SJ, et al. Cell, 2021 Jun 10. PMID 34004147, Free PMC Article
    4. A large-scale in situ screen provides molecular evidence for the induction of eye anterior segment structures by the developing lens. Thut CJ, et al. Dev Biol, 2001 Mar 1. PMID 11180952
    5. Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks. Latos PA, et al. Genes Dev, 2015 Dec 1. PMID 26584622, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Transgenic (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in snRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of integrator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    integrator complex subunit 6
    Names
    DBI-1
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26
    int6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008715.2 → NP_032741.2  integrator complex subunit 6

      See identical proteins and their annotated locations for NP_032741.2

      Status: PROVISIONAL

      Source sequence(s)
      BC059263
      Consensus CDS
      CCDS27191.1
      UniProtKB/Swiss-Prot
      Q3TA02, Q61204, Q6PCM2, Q6PDL7, Q8BQZ7
      Related
      ENSMUSP00000086788.5, ENSMUST00000053959.7
      Conserved Domains (2) summary
      pfam15300
      Location:806 → 864
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
      pfam13519
      Location:4 → 131
      VWA_2; von Willebrand factor type A domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      62913774..62998617 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315909.3 → XP_017171398.1  integrator complex subunit 6 isoform X3

      UniProtKB/Swiss-Prot
      Q6PCM2
      Conserved Domains (2) summary
      pfam15300
      Location:797 → 855
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
      pfam13519
      Location:4 → 131
      VWA_2; von Willebrand factor type A domain

    2. XM_006518680.5 → XP_006518743.1  integrator complex subunit 6 isoform X1

      See identical proteins and their annotated locations for XP_006518743.1

      Conserved Domains (2) summary
      pfam15300
      Location:807 → 865
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
      pfam13519
      Location:4 → 131
      VWA_2; von Willebrand factor type A domain

    3. XM_017315908.3 → XP_017171397.1  integrator complex subunit 6 isoform X1

      Conserved Domains (2) summary
      pfam15300
      Location:807 → 865
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
      pfam13519
      Location:4 → 131
      VWA_2; von Willebrand factor type A domain

    4. XM_011244985.4 → XP_011243287.1  integrator complex subunit 6 isoform X1

      See identical proteins and their annotated locations for XP_011243287.1

      Conserved Domains (2) summary
      pfam15300
      Location:807 → 865
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
      pfam13519
      Location:4 → 131
      VWA_2; von Willebrand factor type A domain

    5. XM_011244986.4 → XP_011243288.1  integrator complex subunit 6 isoform X2

      See identical proteins and their annotated locations for XP_011243288.1

      UniProtKB/Swiss-Prot
      Q3TA02, Q61204, Q6PCM2, Q6PDL7, Q8BQZ7
      Related
      ENSMUSP00000152954.2, ENSMUST00000223585.2
      Conserved Domains (2) summary
      pfam15300
      Location:806 → 864
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
      pfam13519
      Location:4 → 131
      VWA_2; von Willebrand factor type A domain

    6. XM_006518682.5 → XP_006518745.1  integrator complex subunit 6 isoform X3

      See identical proteins and their annotated locations for XP_006518745.1

      UniProtKB/Swiss-Prot
      Q6PCM2
      Conserved Domains (2) summary
      pfam15300
      Location:797 → 855
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
      pfam13519
      Location:4 → 131
      VWA_2; von Willebrand factor type A domain

    7. XM_036158504.1 → XP_036014397.1  integrator complex subunit 6 isoform X5

      Conserved Domains (1) summary
      pfam15300
      Location:618 → 677
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    8. XM_006518683.4 → XP_006518746.1  integrator complex subunit 6 isoform X4

      Conserved Domains (1) summary
      pfam15300
      Location:629 → 687
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PCM2.1 GenPept UniProtKB/Swiss-Prot:Q6PCM2

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