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    NDUFA3 NADH:ubiquinone oxidoreductase subunit A3 [ Homo sapiens (human) ]

    Gene ID: 4696, updated on 10-Dec-2024

    Summary

    Official Symbol
    NDUFA3provided by HGNC
    Official Full Name
    NADH:ubiquinone oxidoreductase subunit A3provided by HGNC
    Primary source
    HGNC:HGNC:7686
    See related
    Ensembl:ENSG00000170906 MIM:603832; AllianceGenome:HGNC:7686
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B9; CI-B9
    Summary
    Involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Part of mitochondrial inner membrane and respiratory chain complex I. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney (RPKM 30.6), fat (RPKM 26.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NDUFA3 in Genome Data Viewer
    Location:
    19q13.42
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (54102855..54107568)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (57180922..57186265)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (54606163..54610875)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene T cell-interacting, activating receptor on myeloid cells 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54605952-54606928 Neighboring gene osteoclast associated Ig-like receptor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54617323-54618196 Neighboring gene TCF3 fusion partner Neighboring gene PRPF31 antisense RNA 1 Neighboring gene pre-mRNA processing factor 31 Neighboring gene CCR4-NOT transcription complex subunit 3 Neighboring gene uncharacterized LOC102724273

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    General protein information

    Preferred Names
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
    Names
    NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
    NADH-ubiquinone oxidoreductase B9 subunit
    complex I B9 subunit
    complex I-B9
    NP_004533.1
    XP_054177044.1
    XP_054185658.1
    XP_054186153.1
    XP_054186450.1
    XP_054186933.1
    XP_054187214.1
    XP_054187489.1
    XP_054189529.1
    XP_054189630.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004542.4 → NP_004533.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

      See identical proteins and their annotated locations for NP_004533.1

      Status: VALIDATED

      Source sequence(s)
      AC245052, BC061644
      Consensus CDS
      CCDS12877.1
      UniProtKB/Swiss-Prot
      O95167
      UniProtKB/TrEMBL
      Q6FGG4
      Related
      ENSP00000418438.1, ENST00000485876.6
      Conserved Domains (1) summary
      pfam14987
      Location:7 → 84
      NADHdh_A3; NADH dehydrogenase 1 alpha subcomplex subunit 3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      54102855..54107568
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003571054.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      76646..81988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329683.1 → XP_054185658.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1

      UniProtKB/Swiss-Prot
      O95167
      UniProtKB/TrEMBL
      Q6FGG4

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NW_003571055.2 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      76759..81988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330178.1 → XP_054186153.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1

      UniProtKB/Swiss-Prot
      O95167
      UniProtKB/TrEMBL
      Q6FGG4

    Reference GRCh38.p14 ALT_REF_LOCI_3

    Genomic

    1. NW_003571056.2 Reference GRCh38.p14 ALT_REF_LOCI_3

      Range
      76646..81988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330475.1 → XP_054186450.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1

      UniProtKB/Swiss-Prot
      O95167
      UniProtKB/TrEMBL
      Q6FGG4

    Reference GRCh38.p14 ALT_REF_LOCI_4

    Genomic

    1. NW_003571057.2 Reference GRCh38.p14 ALT_REF_LOCI_4

      Range
      77276..81988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_5

    Genomic

    1. NW_003571058.2 Reference GRCh38.p14 ALT_REF_LOCI_5

      Range
      76646..81988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330958.1 → XP_054186933.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1

      UniProtKB/Swiss-Prot
      O95167
      UniProtKB/TrEMBL
      Q6FGG4

    Reference GRCh38.p14 ALT_REF_LOCI_6

    Genomic

    1. NW_003571059.2 Reference GRCh38.p14 ALT_REF_LOCI_6

      Range
      76646..81988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331239.1 → XP_054187214.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1

      UniProtKB/Swiss-Prot
      O95167
      UniProtKB/TrEMBL
      Q6FGG4

    Reference GRCh38.p14 ALT_REF_LOCI_7

    Genomic

    1. NW_003571060.1 Reference GRCh38.p14 ALT_REF_LOCI_7

      Range
      76646..81988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331514.1 → XP_054187489.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1

      UniProtKB/Swiss-Prot
      O95167
      UniProtKB/TrEMBL
      Q6FGG4

    Reference GRCh38.p14 ALT_REF_LOCI_8

    Genomic

    1. NW_003571061.2 Reference GRCh38.p14 ALT_REF_LOCI_8

      Range
      76759..81988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333554.1 → XP_054189529.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1

      UniProtKB/Swiss-Prot
      O95167
      UniProtKB/TrEMBL
      Q6FGG4

    Reference GRCh38.p14 ALT_REF_LOCI_9

    Genomic

    1. NT_187693.1 Reference GRCh38.p14 ALT_REF_LOCI_9

      Range
      76646..81988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333655.1 → XP_054189630.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1

      UniProtKB/Swiss-Prot
      O95167
      UniProtKB/TrEMBL
      Q6FGG4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      57180922..57186265
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321069.1 → XP_054177044.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1

      UniProtKB/Swiss-Prot
      O95167
      UniProtKB/TrEMBL
      Q6FGG4
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