Fgf14 fibroblast growth factor 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fgf14provided by MGI
Official Full Name: fibroblast growth factor 14provided by MGI
Primary source: MGI:MGI:109189
See related: Ensembl:ENSMUSG00000025551 AllianceGenome:MGI:109189
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fhf4; FHF-4; Fgf1b; FGF-14; mFHF-4(1B); Tg(tetO-MAPT*P301L)4510Kha
Summary: Predicted to enable growth factor activity; heparin binding activity; and sodium channel regulator activity. Acts upstream of or within several processes, including adult locomotory behavior; neuromuscular process; and positive regulation of sodium ion transport. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; respiratory system; and sensory organ. Used to study Alzheimer's disease; frontotemporal dementia; and spinocerebellar ataxia type 27. Human ortholog(s) of this gene implicated in autosomal dominant cerebellar ataxia. Orthologous to human FGF14 (fibroblast growth factor 14). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 4.3), cortex adult (RPKM 2.4) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 E5; 14 66.18 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (124211257..124915098, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (123974441..124677686, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TNFR1 signaling converging on FGF14 controls neuronal hyperactivity and sickness behavior in experimental cerebral malaria.
Title: TNFR1 signaling converging on FGF14 controls neuronal hyperactivity and sickness behavior in experimental cerebral malaria.
Nav1.3 and FGF14 are primary determinants of the TTX-sensitive sodium current in mouse adrenal chromaffin cells.
Title: Nav1.3 and FGF14 are primary determinants of the TTX-sensitive sodium current in mouse adrenal chromaffin cells.
JAK2 regulates Nav1.6 channel function via FGF14(Y158) phosphorylation.
Title: JAK2 regulates Nav1.6 channel function via FGF14(Y158) phosphorylation.
Effects of FGF14 and NaVbeta4 deletion on transient and resurgent Na current in cerebellar Purkinje neurons.
Title: Effects of FGF14 and Na(V)β4 deletion on transient and resurgent Na current in cerebellar Purkinje neurons.
These new insights into the biology of FGF14 in neurogenesis shed light into the signaling pathways associated with disrupted functions in complex brain diseases.
Title: Fibroblast Growth Factor 14 Modulates the Neurogenesis of Granule Neurons in the Adult Dentate Gyrus.
These results indicate that Fgf14(-/-) mice recapitulate salient molecular, cellular, functional and behavioral features associated with human cognitive impairment, and FGF14 loss of function might be associated with the biology of complex brain disorders such as schizophrenia.
Title: Genetic deletion of fibroblast growth factor 14 recapitulates phenotypic alterations underlying cognitive impairment associated with schizophrenia.
TWEAK/Fn14 pathway instrumental in the pathogenesis of spontaneous lupus nephritis
Title: Deficiency of fibroblast growth factor-inducible 14 (Fn14) preserves the filtration barrier and ameliorates lupus nephritis.
The results of this study demonstrated that iFGF14 is required for spontaneous and evoked action potential firing in adult Purkinje neurons, thereby controlling the output of these cells and the regulation of motor coordination and balance.
Title: Intracellular FGF14 (iFGF14) Is Required for Spontaneous and Evoked Firing in Cerebellar Purkinje Neurons and for Motor Coordination and Balance.
These data suggest that the FGF14b N-terminus is a potent regulator of resurgent NaV current in cerebellar Purkinje neurons.
Title: FGF14 modulates resurgent sodium current in mouse cerebellar Purkinje neurons.
FGF14 is localized in a decreasing proximal to distal gradient along the axon initial segment of Purkinje neurons.
Title: FGF14 localization and organization of the axon initial segment.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (1) 1 citation
Transgenic (1) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:484865

RH126827 (e-PCR)
- UniSTS:207395

Fgf14 (e-PCR), detects polymorphism
- UniSTS:258260

Fgf14 (e-PCR), detects polymorphism
- UniSTS:507872

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables fibroblast growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables sodium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within JNK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adult locomotory behavior	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within chemical synaptic transmission	IGI Inferred from Genetic Interaction more info	PubMed
NOT acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuromuscular process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of high voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of sodium ion transport	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of synaptic vesicle recycling	ISO Inferred from Sequence Orthology more info
involved_in regulation of voltage-gated sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fibroblast growth factor 14

Names: fibroblast growth factor 1b; fibroblast growth factor homologous factor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010201.5 → NP_034331.2 fibroblast growth factor 14 isoform a

See identical proteins and their annotated locations for NP_034331.2

Status: VALIDATED

Source sequence(s)

AC154195, AC161001

Consensus CDS

CCDS27356.1

UniProtKB/Swiss-Prot

P70379, Q3KNZ6, Q8BST0, Q9JHL9

UniProtKB/TrEMBL

A0A0R4J063

Related

ENSMUSP00000026631.6, ENSMUST00000026631.6

Conserved Domains (1) summary

pfam00167
Location:72 → 197

FGF; Fibroblast growth factor
NM_207667.4 → NP_997550.1 fibroblast growth factor 14 isoform b

See identical proteins and their annotated locations for NP_997550.1

Status: VALIDATED

Source sequence(s)

AC154195, AC161001, AC164978

Consensus CDS

CCDS27355.1

UniProtKB/TrEMBL

O89096

Related

ENSMUSP00000093185.4, ENSMUST00000095529.10

Conserved Domains (1) summary

pfam00167
Location:77 → 202

FGF; Fibroblast growth factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

124211257..124915098 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017315845.2 → XP_017171334.1 fibroblast growth factor 14 isoform X1

Conserved Domains (1) summary

smart00442
Location:22 → 152

FGF; Acidic and basic fibroblast growth factor family
XM_011244952.4 → XP_011243254.1 fibroblast growth factor 14 isoform X2

See identical proteins and their annotated locations for XP_011243254.1

UniProtKB/Swiss-Prot

P70379

Conserved Domains (1) summary

pfam00167
Location:1 → 113

FGF; Fibroblast growth factor
XM_006518549.5 → XP_006518612.1 fibroblast growth factor 14 isoform X3

Conserved Domains (1) summary

cl00060
Location:74 → 141

FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...