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    Ppp1r42 protein phosphatase 1, regulatory subunit 42 [ Mus musculus (house mouse) ]

    Gene ID: 69312, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ppp1r42provided by MGI
    Official Full Name
    protein phosphatase 1, regulatory subunit 42provided by MGI
    Primary source
    MGI:MGI:1921138
    See related
    Ensembl:ENSMUSG00000025916 AllianceGenome:MGI:1921138
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TLRR; Lrrc67; 1700011J18Rik; 4930418G15Rik
    Summary
    Enables actin binding activity; dynein complex binding activity; and tubulin binding activity. Involved in regulation of phosphatase activity. Located in centrosome and manchette. Is expressed in 4th ventricle lateral recess and lateral ventricle choroid plexus. Orthologous to human PPP1R42 (protein phosphatase 1 regulatory subunit 42). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 1.4), liver E18 (RPKM 0.1) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Ppp1r42 in Genome Data Viewer
    Location:
    1 A2; 1 2.25 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (10038847..10083766, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (9968622..10013541, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4304 Neighboring gene small nucleolar RNA, C/D box 87 Neighboring gene small nucleolar RNA host gene 6 Neighboring gene transcription factor 24 Neighboring gene STARR-seq mESC enhancer starr_00178 Neighboring gene STARR-seq mESC enhancer starr_00179 Neighboring gene predicted gene, 24674 Neighboring gene STARR-positive B cell enhancer ABC_E270 Neighboring gene COP9 signalosome subunit 5 Neighboring gene centrosome and spindle pole associated protein 1 Neighboring gene STARR-seq mESC enhancer starr_00181 Neighboring gene ARF guanine nucleotide exchange factor 1 Neighboring gene STARR-seq mESC enhancer starr_00182

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PP1 forms an active complex with TLRR (lrrc67), a putative PP1 regulatory subunit, during the early stages of spermiogenesis in mice. Wang R, et al. PLoS One, 2011. PMID 21738792, Free PMC Article
    2. Identification of a novel Leucine-rich repeat protein and candidate PP1 regulatory subunit expressed in developing spermatids. Wang R, et al. BMC Cell Biol, 2008 Jan 31. PMID 18237440, Free PMC Article
    3. TLRR (lrrc67) interacts with PP1 and is associated with a cytoskeletal complex in the testis. Wang R, et al. Biol Cell, 2010 Jan 13. PMID 19886865, Free PMC Article
    4. Gene-deficient mouse model established by CRISPR/Cas9 system reveals 15 reproductive organ-enriched genes dispensable for male fertility. Nguyen TTT, et al. Front Cell Dev Biol, 2024. PMID 38835510, Free PMC Article
    5. Tissue expression patterns identify mouse cilia genes. McClintock TS, et al. Physiol Genomics, 2008 Jan 17. PMID 17971504

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our finding that TLRR is associated with microtubules in cultured cells suggests that TLRR may play a common role in modulating the cytoskeleton in other cell types besides male germ cells.
      Title: TLRR (lrrc67) interacts with PP1 and is associated with a cytoskeletal complex in the testis.
    2. Identification of a previously uncharacterized leucine-rich repeat protein that is expressed abundantly in the testis.[TLRR; NM_027033.1, NM_145692.1]
      Title: Identification of a novel Leucine-rich repeat protein and candidate PP1 regulatory subunit expressed in developing spermatids.
    3. 4930418G15Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
      Title: Tissue expression patterns identify mouse cilia genes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2)  1 citation
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dynein complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tubulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in manchette IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule organizing center IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein phosphatase 1 regulatory subunit 42
    Names
    leucine rich repeat containing 67
    testis leucine-rich repeat protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145692.2 → NP_663730.1  protein phosphatase 1 regulatory subunit 42

      See identical proteins and their annotated locations for NP_663730.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript and encodes the protein.
      Source sequence(s)
      AK076637, AV253491
      Consensus CDS
      CCDS14817.1
      UniProtKB/Swiss-Prot
      Q8R1Z4, Q9D5M1, Q9DAF9
      Related
      ENSMUSP00000027049.4, ENSMUST00000027049.10
      Conserved Domains (3) summary
      sd00033
      Location:31 → 51
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:72 → 106
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:50 → 106
      LRR_8; Leucine rich repeat

    RNA

    1. NR_110971.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate 3' exons, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK015164, AK076637, AV253491
      Related
      ENSMUST00000130102.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      10038847..10083766 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495566.3 → XP_006495629.1  protein phosphatase 1 regulatory subunit 42 isoform X2

      UniProtKB/TrEMBL
      E9PUJ7
      Related
      ENSMUSP00000115309.2, ENSMUST00000124874.8
      Conserved Domains (2) summary
      sd00031
      Location:30 → 51
      LRR_1; leucine-rich repeat [structural motif]
      NF033189
      Location:27 → 180
      internalin_A; class 1 internalin InlA

    2. XM_006495565.2 → XP_006495628.1  protein phosphatase 1 regulatory subunit 42 isoform X1

      UniProtKB/TrEMBL
      E9PUJ7
      Conserved Domains (2) summary
      sd00031
      Location:30 → 51
      LRR_1; leucine-rich repeat [structural motif]
      NF033189
      Location:27 → 180
      internalin_A; class 1 internalin InlA

    RNA

    1. XR_003946510.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_027033.4: Suppressed sequence

      Description
      NM_027033.4: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R1Z4.1 GenPept UniProtKB/Swiss-Prot:Q8R1Z4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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