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    Spin1 spindlin 1 [ Mus musculus (house mouse) ]

    Gene ID: 20729, updated on 27-Nov-2024

    Summary

    Official Symbol
    Spin1provided by MGI
    Official Full Name
    spindlin 1provided by MGI
    Primary source
    MGI:MGI:109242
    See related
    Ensembl:ENSMUSG00000021395 AllianceGenome:MGI:109242
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Spin; SSEC P
    Summary
    Predicted to enable methylated histone binding activity. Predicted to be involved in positive regulation of DNA-templated transcription; positive regulation of Wnt signaling pathway; and rRNA transcription. Predicted to act upstream of or within female meiotic nuclear division. Located in spindle. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human SPIN1 (spindlin 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 12.2), whole brain E14.5 (RPKM 10.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Spin1 in Genome Data Viewer
    Location:
    13 A5; 13 26.04 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (51254523..51306588)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (51097934..51152562)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene 8779 Neighboring gene predicted gene, 32613 Neighboring gene STARR-seq mESC enhancer starr_34498 Neighboring gene STARR-seq mESC enhancer starr_34499 Neighboring gene STARR-seq mESC enhancer starr_34501 Neighboring gene STARR-seq mESC enhancer starr_34502 Neighboring gene STARR-seq mESC enhancer starr_34504 Neighboring gene RIKEN cDNA 9430083A17 gene Neighboring gene STARR-seq mESC enhancer starr_34507 Neighboring gene STARR-seq mESC enhancer starr_34508 Neighboring gene STARR-seq mESC enhancer starr_34509 Neighboring gene nucleoredoxin-like 2 Neighboring gene H2A histone family, pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (4)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC27756

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone reader activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables methylated histone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    spindlin-1
    Names
    30000 Mr metaphase complex
    spindlin1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001283028.2NP_001269957.1  spindlin-1 isoform 2

      See identical proteins and their annotated locations for NP_001269957.1

      Status: VALIDATED

      Source sequence(s)
      AC160122
      Consensus CDS
      CCDS26510.1
      UniProtKB/Swiss-Prot
      Q3TLC3, Q3UT05, Q61142, Q91VG8
      UniProtKB/TrEMBL
      Q3UX91
      Conserved Domains (1) summary
      pfam02513
      Location:54102
      Spin-Ssty; Spin/Ssty Family
    2. NM_001283029.2NP_001269958.1  spindlin-1 isoform 2

      See identical proteins and their annotated locations for NP_001269958.1

      Status: VALIDATED

      Source sequence(s)
      AC160122
      Consensus CDS
      CCDS26510.1
      UniProtKB/Swiss-Prot
      Q3TLC3, Q3UT05, Q61142, Q91VG8
      UniProtKB/TrEMBL
      Q3UX91
      Conserved Domains (1) summary
      pfam02513
      Location:54102
      Spin-Ssty; Spin/Ssty Family
    3. NM_001283030.2NP_001269959.1  spindlin-1 isoform 3

      See identical proteins and their annotated locations for NP_001269959.1

      Status: VALIDATED

      Source sequence(s)
      AC160122
      UniProtKB/TrEMBL
      Q3UX91
      Conserved Domains (1) summary
      pfam02513
      Location:2977
      Spin-Ssty; Spin/Ssty Family
    4. NM_001419135.1NP_001406064.1  spindlin-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC160122
      UniProtKB/Swiss-Prot
      Q3TLC3, Q3UT05, Q61142, Q91VG8
    5. NM_001419139.1NP_001406068.1  spindlin-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC160122
      UniProtKB/Swiss-Prot
      Q3TLC3, Q3UT05, Q61142, Q91VG8
    6. NM_001419140.1NP_001406069.1  spindlin-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC160122
      UniProtKB/Swiss-Prot
      Q3TLC3, Q3UT05, Q61142, Q91VG8
    7. NM_001419141.1NP_001406070.1  spindlin-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC160122
      UniProtKB/Swiss-Prot
      Q3TLC3, Q3UT05, Q61142, Q91VG8
    8. NM_011462.4NP_035592.1  spindlin-1 isoform 1

      See identical proteins and their annotated locations for NP_035592.1

      Status: VALIDATED

      Source sequence(s)
      AC160122
      UniProtKB/TrEMBL
      Q3TQU6
      Related
      ENSMUST00000223152.2
      Conserved Domains (1) summary
      pfam02513
      Location:3280
      Spin-Ssty; Spin/Ssty Family
    9. NM_146043.5NP_666155.1  spindlin-1 isoform 2

      See identical proteins and their annotated locations for NP_666155.1

      Status: VALIDATED

      Source sequence(s)
      AC160122
      Consensus CDS
      CCDS26510.1
      UniProtKB/Swiss-Prot
      Q3TLC3, Q3UT05, Q61142, Q91VG8
      UniProtKB/TrEMBL
      Q3UX91
      Related
      ENSMUSP00000093473.6, ENSMUST00000095797.6
      Conserved Domains (1) summary
      pfam02513
      Location:54102
      Spin-Ssty; Spin/Ssty Family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      51254523..51306588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315469.3XP_017170958.1  spindlin-1 isoform X1

      UniProtKB/Swiss-Prot
      Q3TLC3, Q3UT05, Q61142, Q91VG8
      UniProtKB/TrEMBL
      Q3UX91
      Conserved Domains (1) summary
      pfam02513
      Location:54102
      Spin-Ssty; Spin/Ssty Family