Ncdn neurochondrin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ncdnprovided by MGI
Official Full Name: neurochondrinprovided by MGI
Primary source: MGI:MGI:1347351
See related: Ensembl:ENSMUSG00000028833 AllianceGenome:MGI:1347351
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ms10ae; norbin; MMS10-AE; mKIAA0607
Summary: Involved in neuron projection development and regulation of postsynaptic neurotransmitter receptor internalization. Acts upstream of or within bone resorption. Located in neuron projection. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including central nervous system; dorsal root ganglion; femur; and tendon. Orthologous to human NCDN (neurochondrin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in frontal lobe adult (RPKM 191.8), cortex adult (RPKM 179.9) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4; 4 D2.2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (126637548..126647203, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (126743750..126753765, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of Metabotropic Glutamate Receptor Internalization and Synaptic AMPA Receptor Endocytosis by the Postsynaptic Protein Norbin.
Title: Regulation of Metabotropic Glutamate Receptor Internalization and Synaptic AMPA Receptor Endocytosis by the Postsynaptic Protein Norbin.
The GPCR adaptor protein norbin suppresses the neutrophil-mediated immunity of mice to pneumococcal infection.
Title: The GPCR adaptor protein norbin suppresses the neutrophil-mediated immunity of mice to pneumococcal infection.
A novel mechanism of P-Rex1 regulation through the GPCR-adaptor protein Norbin.
Title: Norbin Stimulates the Catalytic Activity and Plasma Membrane Localization of the Guanine-Nucleotide Exchange Factor P-Rex1.
Norbin is a regulator of adult hippocampal neurogenesis and that its deletion causes depressive-like behaviors.
Title: Norbin ablation results in defective adult hippocampal neurogenesis and depressive-like behavior in mice.
In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
Title: In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
study reports that Norbin, a neuron-specific protein, physically interacts with mGluR5 in vivo, increases the cell surface localization of the receptor, and positively regulates mGluR5 signaling
Title: Norbin is an endogenous regulator of metabotropic glutamate receptor 5 signaling.
results showed that neurochondrin is a negative regulator of Ca(2+)/calmodulin-dependent protein kinase II phosphorylation and specific homozygous gene disruption resulted in epileptic seizure
Title: Neurochondrin negatively regulates CaMKII phosphorylation, and nervous system-specific gene disruption results in epileptic seizure.
Neurochondrin expression pattern in the developing and adult brain.
Title: Expression of neurochondrin in the developing and adult mouse brain.
neurochondrin/norbin gene function is essential for the early embryogenesis
Title: Targeted disruption of the neurochondrin/norbin gene results in embryonic lethality.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within bone resorption	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of neuronal synaptic plasticity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of neuronal synaptic plasticity	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
NOT located_in axon	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info
NOT located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in postsynapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neurochondrin

Names: M-Sema F-associating protein of 75 kDa; minisatellite 10ae detected by probe MMS10; neurochondrin-1; neurochondrin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355412.2 → NP_001342341.1 neurochondrin isoform 2

Status: VALIDATED

Source sequence(s)

AL606908

Conserved Domains (1) summary

pfam05536
Location:13 → 620

Neurochondrin
NM_001355413.2 → NP_001342342.1 neurochondrin isoform 2

Status: VALIDATED

Source sequence(s)

AL606908

Conserved Domains (1) summary

pfam05536
Location:13 → 620

Neurochondrin
NM_001424941.1 → NP_001411870.1 neurochondrin isoform 1

Status: VALIDATED

Source sequence(s)

AL606908

UniProtKB/Swiss-Prot

Q3TCW4, Q80TW1, Q91YH7, Q9CW81, Q9QUQ0, Q9Z0E0

Related

ENSMUSP00000101722.2, ENSMUST00000106116.2
NM_001424942.1 → NP_001411871.1 neurochondrin isoform 2

Status: VALIDATED

Source sequence(s)

AL606908
NM_001424943.1 → NP_001411872.1 neurochondrin isoform 3

Status: VALIDATED

Source sequence(s)

AL606908
NM_001424944.1 → NP_001411873.1 neurochondrin isoform 4

Status: VALIDATED

Source sequence(s)

AL606908
NM_001424945.1 → NP_001411874.1 neurochondrin isoform 4

Status: VALIDATED

Source sequence(s)

AL606908
NM_011986.5 → NP_036116.3 neurochondrin isoform 1

See identical proteins and their annotated locations for NP_036116.3

Status: VALIDATED

Source sequence(s)

AL606908

Consensus CDS

CCDS18659.1

UniProtKB/Swiss-Prot

Q3TCW4, Q80TW1, Q91YH7, Q9CW81, Q9QUQ0, Q9Z0E0

Related

ENSMUSP00000030637.8, ENSMUST00000030637.14

Conserved Domains (1) summary

pfam05536
Location:30 → 637

Neurochondrin