Tnfaip2 tumor necrosis factor, alpha-induced protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnfaip2provided by MGI
Official Full Name: tumor necrosis factor, alpha-induced protein 2provided by MGI
Primary source: MGI:MGI:104960
See related: Ensembl:ENSMUSG00000021281 AllianceGenome:MGI:104960
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B94; M-sec; Tnfip2; tnfb94; Exoc3l3
Summary: Predicted to enable SNARE binding activity. Predicted to be involved in exocyst localization and exocytosis. Predicted to be part of exocyst. Is expressed in several structures, including embryo mesenchyme; future brain; genitourinary system; immune system; and sensory organ. Used to study focal segmental glomerulosclerosis. Orthologous to human TNFAIP2 (TNF alpha induced protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in bladder adult (RPKM 39.6), liver E14.5 (RPKM 31.1) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 F1; 12 60.99 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (111408898..111421452)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (111442450..111455018)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Screening UFMylation-associated genes in heart tissues of Ufm1-transgenic mice.
Title: Screening UFMylation-associated genes in heart tissues of Ufm1-transgenic mice.
Tnfaip2 promotes atherogenesis by enhancing oxidative stress induced inflammation.
Title: Tnfaip2 promotes atherogenesis by enhancing oxidative stress induced inflammation.
Knockdown of TNFaip2 in Raw264.7 cells inhibited formation of tunneling nanotubes.
Title: M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

General gene information

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Markers

L24118 (e-PCR)
- UniSTS:124884

L24118 (e-PCR)
- UniSTS:180479

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in exocyst localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in exocytosis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of exocyst	IBA Inferred from Biological aspect of Ancestor more info
part_of exocyst	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tumor necrosis factor alpha-induced protein 2

Names: TNF alpha-induced protein 2; primary response gene B94 protein; tumor necrosis factor induced protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009396.2 → NP_033422.2 tumor necrosis factor alpha-induced protein 2

See identical proteins and their annotated locations for NP_033422.2

Status: VALIDATED

Source sequence(s)

BP767166, BY202445, L24118

Consensus CDS

CCDS26178.2

UniProtKB/Swiss-Prot

Q3T9B0, Q3TCH9, Q61333, Q922G1

UniProtKB/TrEMBL

D3Z4L9

Related

ENSMUSP00000099806.4, ENSMUST00000102745.10

Conserved Domains (1) summary

pfam06046
Location:157 → 688

Sec6; Exocyst complex component Sec6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

111408898..111421452

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006515793.5 → XP_006515856.1 tumor necrosis factor alpha-induced protein 2 isoform X2

Conserved Domains (1) summary

cl19885
Location:157 → 412

Sec6; Exocyst complex component Sec6
XM_036157378.1 → XP_036013271.1 tumor necrosis factor alpha-induced protein 2 isoform X1