Nfkbib nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nfkbibprovided by MGI
Official Full Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, betaprovided by MGI
Primary source: MGI:MGI:104752
See related: Ensembl:ENSMUSG00000030595 AllianceGenome:MGI:104752
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IkB; IkBb; ikB-B; IKB-beta; IKappaBbeta; NF-kappa-BIB; I-kappa-B-beta; I(Kappa)B(beta)
Summary: This gene encodes an inhibitor of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB). The encoded protein prevents NF-kappaB-mediated transcription activation by sequestering it in the cytosol. In response to signals that induce NF-kappaB, such as cytokines and growth factors, the encoded protein undergoes phosphorylation, triggering its rapid ubiquitination and proteasomal degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression: Ubiquitous expression in testis adult (RPKM 35.6), duodenum adult (RPKM 28.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B1; 7 16.91 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (28457676..28466069, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (28758251..28766644, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CpG-ODN-mediated TLR9 innate immune signalling and calcium dyshomeostasis converge on the NFkappaB inhibitory protein IkappaBbeta to drive IL1alpha and IL1beta expression.
Title: CpG-ODN-mediated TLR9 innate immune signalling and calcium dyshomeostasis converge on the NFκB inhibitory protein IκBβ to drive IL1α and IL1β expression.
IkappaBbeta has essential functions within the Rel-NFkappaB generation module, specifically for the RelA:RelA homodimer, which controls a subset of NFkappaB target genes.
Title: IκBβ enhances the generation of the low-affinity NFκB/RelA homodimer.
these results mechanistically link the innate immune response mediated by IkappaBbeta/NF-kappaB to ET-1 expression and potentially reveal therapeutic targets for patients with Gram-negative septic shock.
Title: Endotoxemia Induces IκBβ/NF-κB-Dependent Endothelin-1 Expression in Hepatic Macrophages.
Dengue virus protease interacts with both IkappaBalpha and IkappaBbeta cleaving them in a mouse hemorrhage model.
Title: Dengue viral protease interaction with NF-κB inhibitor α/β results in endothelial cell apoptosis and hemorrhage development.
sustained NF-kappaB activity mediated by IkappaBbeta protects against hyperoxic lung injury through increased expression of antiapoptotic genes
Title: IκBβ-mediated NF-κB activation confers protection against hyperoxic lung injury.
Findings represent a necessary but not sufficient role of IkappaBbeta in preventing oxidant stress-induced cell death.
Title: Nuclear factor-κB (NF-κB) inhibitory protein IκBβ determines apoptotic cell death following exposure to oxidative stress.
IkappaBbeta is an essential co-activator for LPS-induced IL-1beta transcription in vivo.
Title: IkappaBbeta is an essential co-activator for LPS-induced IL-1beta transcription in vivo.
IkappaBbeta acts through p65:c-Rel dimers to maintain prolonged expression of TNF-alpha
Title: IkappaBbeta acts to inhibit and activate gene expression during the inflammatory response.
These results show that mitochondrial stress signaling uses an IkappaBbeta-initiated NFkappaB pathway that is distinct from the other known NFkappaB pathways.
Title: A distinctive physiological role for IkappaBbeta in the propagation of mitochondrial respiratory stress signaling.
In vivo degradation rate constants were measured for NF-kappaB-bound & -unbound IkappaB. Models suggest differential degradation rates of free & bound IkappaB may be a new cross-regulation mechanism imparting functional robustness to the signaling module.
Title: A homeostatic model of IkappaB metabolism to control constitutive NF-kappaB activity.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within inflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of canonical NF-kappaB signal transduction	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NF-kappa-B inhibitor beta

Names: nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001306222.1 → NP_001293151.1 NF-kappa-B inhibitor beta

See identical proteins and their annotated locations for NP_001293151.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC171210, AK010218, AK038631, BM899229

Consensus CDS

CCDS21054.1

UniProtKB/Swiss-Prot

Q564F1, Q60778, Q9D6L5

UniProtKB/TrEMBL

Q8VC27

Related

ENSMUSP00000083012.6, ENSMUST00000085851.12

Conserved Domains (4) summary

cd00204
Location:202 → 298

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:211 → 298

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:58 → 113

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:206 → 237

ANK; ANK repeat [structural motif]
NM_010908.5 → NP_035038.2 NF-kappa-B inhibitor beta

See identical proteins and their annotated locations for NP_035038.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC171210, AK038631

Consensus CDS

CCDS21054.1

UniProtKB/Swiss-Prot

Q564F1, Q60778, Q9D6L5

UniProtKB/TrEMBL

Q8VC27

Related

ENSMUSP00000032815.5, ENSMUST00000032815.11

Conserved Domains (4) summary

cd00204
Location:202 → 298

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:211 → 298

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:58 → 113

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:206 → 237

ANK; ANK repeat [structural motif]