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    RER1 protein retrieval receptor [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850354, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RER1
    Official Full Name
    protein retrieval receptor
    Primary source
    SGD:S000000507
    Locus tag
    YCL001W
    See related
    AllianceGenome:SGD:S000000507; FungiDB:YCL001W; VEuPathDB:YCL001W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in protein retention in ER lumen and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in COPI-coated vesicle; COPII-coated ER to Golgi transport vesicle; and fungal-type vacuole. Orthologous to human RER1 (retention in endoplasmic reticulum sorting receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RER1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (111916..112482)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Kex2-dependent invertase secretion as a tool to study the targeting of transmembrane proteins which are involved in ER-->Golgi transport in yeast. Boehm J, et al. EMBO J, 1994 Aug 15. PMID 8070399, Free PMC Article
    2. Rer1p, a retrieval receptor for endoplasmic reticulum membrane proteins, is dynamically localized to the Golgi apparatus by coatomer. Sato K, et al. J Cell Biol, 2001 Mar 5. PMID 11238450, Free PMC Article
    3. Endoplasmic reticulum quality control of unassembled iron transporter depends on Rer1p-mediated retrieval from the golgi. Sato M, et al. Mol Biol Cell, 2004 Mar. PMID 14699055, Free PMC Article
    4. Rer1p, a retrieval receptor for ER membrane proteins, recognizes transmembrane domains in multiple modes. Sato K, et al. Mol Biol Cell, 2003 Sep. PMID 12972550, Free PMC Article
    5. Endoplasmic reticulum localization of Sec12p is achieved by two mechanisms: Rer1p-dependent retrieval that requires the transmembrane domain and Rer1p-independent retention that involves the cytoplasmic domain. Sato M, et al. J Cell Biol, 1996 Jul. PMID 8707815, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein retention in ER lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein retention in ER lumen IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in COPI-coated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in COPI-coated vesicle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in COPII-coated ER to Golgi transport vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein retrieval receptor
    NP_009925.1
    • Protein involved in retention of membrane proteins; including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      111916..112482
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178651.1 → NP_009925.1  TPA: protein retrieval receptor [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009925.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR09, P25560
      UniProtKB/TrEMBL
      A6ZTI1, B3LU71, B5VEU9, C8Z483, G2WA17, N1PAP7
      Conserved Domains (1) summary
      COG5249
      Location:1 → 183
      RER1; Golgi protein involved in Golgi-to-ER retrieval [Intracellular trafficking and secretion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25560.2

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