Donson downstream neighbor of SON [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Donsonprovided by MGI
Official Full Name: downstream neighbor of SONprovided by MGI
Primary source: MGI:MGI:1890621
See related: Ensembl:ENSMUSG00000022960 AllianceGenome:MGI:1890621
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ORF60; 1110025J21Rik
Summary: Predicted to be involved in DNA-templated DNA replication and mitotic G2/M transition checkpoint. Predicted to be located in replication fork. Predicted to be part of replisome. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; limb; and sensory organ. Human ortholog(s) of this gene implicated in microcephaly, short stature, and limb abnormalities and microcephaly-micromelia syndrome. Orthologous to human DONSON (DNA replication fork stabilization factor DONSON). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 13.4), liver E14 (RPKM 10.6) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C3.3- C4; 16 53.25 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (91463744..91485702, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (91666856..91688932, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The microcephaly gene Donson is essential for progenitors of cortical glutamatergic and GABAergic neurons.
Title: The microcephaly gene Donson is essential for progenitors of cortical glutamatergic and GABAergic neurons.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Targeted (2) 1 citation

General gene information

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Markers

RH125830 (e-PCR)
- UniSTS:162574

Donson (e-PCR), detects polymorphism
- UniSTS:259604

RH127092 (e-PCR)
- UniSTS:209249

RH124814 (e-PCR)
- UniSTS:161636

AI845729 (e-PCR)
- UniSTS:166020

GDB:335409 (e-PCR)
- UniSTS:156598

NoName (e-PCR)
- UniSTS:237547

Donson (e-PCR), detects polymorphism
- UniSTS:259070

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in DNA damage checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA replication	ISO Inferred from Sequence Orthology more info
involved_in DNA replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic DNA replication checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in mitotic DNA replication checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic G2 DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in mitotic G2 DNA damage checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in nuclear DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in replication fork processing	ISO Inferred from Sequence Orthology more info
involved_in replication fork processing	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in replication fork	ISO Inferred from Sequence Orthology more info
located_in replication fork	ISS Inferred from Sequence or Structural Similarity more info
part_of replisome	ISO Inferred from Sequence Orthology more info
part_of replisome	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: protein downstream neighbor of Son

Names: protein 3SG

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.