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    Tlcd2 TLC domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 380712, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tlcd2provided by MGI
    Official Full Name
    TLC domain containing 2provided by MGI
    Primary source
    MGI:MGI:1917141
    See related
    Ensembl:ENSMUSG00000038217 AllianceGenome:MGI:1917141
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be involved in several processes, including membrane assembly; phospholipid homeostasis; and regulation of membrane lipid distribution. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system and retina. Orthologous to human TLCD2 (TLC domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 69.7), duodenum adult (RPKM 20.6) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tlcd2 in Genome Data Viewer
    Location:
    11 B5; 11 45.91 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (75358771..75361725)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (75468024..75470899)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene WD repeat domain 81 Neighboring gene STARR-positive B cell enhancer ABC_E3973 Neighboring gene STARR-positive B cell enhancer ABC_E10687 Neighboring gene STARR-seq mESC enhancer starr_29995 Neighboring gene Mir22 host gene (non-protein coding) Neighboring gene microRNA 22 Neighboring gene STARR-positive B cell enhancer ABC_E591 Neighboring gene pre-mRNA processing factor 8 Neighboring gene STARR-positive B cell enhancer ABC_E7017 Neighboring gene Rab interacting lysosomal protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • 2010305C02Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in membrane assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipid homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in plasma membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in plasma membrane organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in plasma membrane organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of membrane lipid distribution IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of membrane lipid distribution IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of membrane lipid distribution ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TLC domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291156.1 → NP_001278085.1  TLC domain-containing protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AI549721, AK008522, CO044816, CV562896
      Consensus CDS
      CCDS70238.1
      UniProtKB/Swiss-Prot
      Q8VC26
      Related
      ENSMUSP00000104074.2, ENSMUST00000108435.2
      Conserved Domains (1) summary
      cl02759
      Location:33 → 143
      TRAM_LAG1_CLN8; TLC domain

    2. NM_027249.3 → NP_081525.1  TLC domain-containing protein 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI549721, AL591496, CO044816, CV562896
      Consensus CDS
      CCDS48850.1
      UniProtKB/Swiss-Prot
      Q8VC26, Q9D837
      Related
      ENSMUSP00000042958.8, ENSMUST00000043598.14
      Conserved Domains (1) summary
      smart00724
      Location:33 → 225
      TLC; TRAM, LAG1 and CLN8 homology domains

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      75358771..75361725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249099.2 → XP_011247401.1  TLC domain-containing protein 2 isoform X1

      Conserved Domains (1) summary
      cl02759
      Location:33 → 143
      TRAM_LAG1_CLN8; TLC domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VC26.1 GenPept UniProtKB/Swiss-Prot:Q8VC26

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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