Stau2 staufen double-stranded RNA binding protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stau2provided by MGI
Official Full Name: staufen double-stranded RNA binding protein 2provided by MGI
Primary source: MGI:MGI:1352508
See related: Ensembl:ENSMUSG00000025920 AllianceGenome:MGI:1352508
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable several functions, including Hsp70 protein binding activity; RNA binding activity; and kinesin binding activity. Predicted to be involved in several processes, including anterograde dendritic transport of messenger ribonucleoprotein complex; positive regulation of long-term synaptic depression; and positive regulation of nervous system development. Predicted to be located in axon; dendritic shaft; and nuclear membrane. Predicted to be part of protein-containing complex. Predicted to be active in several cellular components, including cytoplasmic stress granule; neuron projection; and neuronal cell body. Is expressed in several structures, including central nervous system; olfactory epithelium; retina; submandibular gland primordium; and tooth. Orthologous to human STAU2 (staufen double-stranded RNA binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in CNS E18 (RPKM 14.6), cortex adult (RPKM 11.5) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 A3; 1 5.05 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (16299027..16591228, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (16228803..16520332, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNF216 affects the stability of STAU2 in the hypothalamus.
Title: RNF216 affects the stability of STAU2 in the hypothalamus.
An in vivo genome-wide CRISPR screen identifies the RNA-binding protein Staufen2 as a key regulator of myeloid leukemia.
Title: An in vivo genome-wide CRISPR screen identifies the RNA-binding protein Staufen2 as a key regulator of myeloid leukemia.
Pumilio2 and Staufen2 selectively balance the synaptic proteome.
Title: Pumilio2 and Staufen2 selectively balance the synaptic proteome.
STAU2 binds a complex RNA cargo that changes temporally with production of diverse intermediate progenitor cells during mouse corticogenesis.
Title: STAU2 binds a complex RNA cargo that changes temporally with production of diverse intermediate progenitor cells during mouse corticogenesis.
Together, our data suggest that Stau2 contributes to novelty preference and explorative behavior that is a driver for proper spatial learning in mice.
Title: Staufen2 deficiency leads to impaired response to novelty in mice.
Stau2 downregulation (Stau2(GT)) led to an increase of glutamate receptor ionotropic delta subunit 2 (GluD2) in Purkinje cells when animals performed physical activity by voluntary wheel running compared with the age-matched wildtype (WT) mice (C57Bl/6J).
Title: Altered Glutamate Receptor Ionotropic Delta Subunit 2 Expression in Stau2-Deficient Cerebellar Purkinje Cells in the Adult Brain.
Study shows that double-stranded RNA binding domains (dsRBDs) 1 and 2 of mStau2 bind RNA with similar affinities and kinetics as dsRBDs 3 and 4. While RNA binding by these tandem domains is transient, all four dsRBDs recognize their target RNAs with high stability. Rescue experiments in Drosophila oocytes demonstrate that mStau2 partially rescues dmStau-dependent mRNA localization.
Title: Staufen2-mediated RNA recognition and localization requires combinatorial action of multiple domains.
Staufen2 interacts with intron i16 containing CaMKIIalpha mRNA and enhances its distal dendritic localization.
Title: Recruitment of Staufen2 Enhances Dendritic Localization of an Intron-Containing CaMKIIα mRNA.
Stau2 is required for spindle formation and timely meiotic progression in mouse oocytes.
Title: RNA- binding protein Stau2 is important for spindle integrity and meiosis progression in mouse oocytes.
Stau2 is distributed asymmetrically during progenitor divisions in the developing mouse cortex, preferentially segregating into the Tbr2( ) neuroblast daughter, taking with it a subset of RNAs.
Title: Asymmetric segregation of the double-stranded RNA binding protein Staufen2 during mammalian neural stem cell divisions promotes lineage progression.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Stau2 (e-PCR), detects polymorphism
- UniSTS:479283

Stau2 (e-PCR), detects polymorphism
- UniSTS:547731

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Hsp70 protein binding	IEA Inferred from Electronic Annotation more info
enables Hsp70 protein binding	ISO Inferred from Sequence Orthology more info
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info	PubMed
enables kinesin binding	IEA Inferred from Electronic Annotation more info
enables kinesin binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mitogen-activated protein kinase binding	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase binding	ISO Inferred from Sequence Orthology more info
enables ribosome binding	IEA Inferred from Electronic Annotation more info
enables ribosome binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in anterograde dendritic transport of messenger ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in anterograde dendritic transport of messenger ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
involved_in anterograde dendritic transport of messenger ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in eye morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in eye morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in germ cell development	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular mRNA localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of dendritic spine morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of long-term synaptic depression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of long-term synaptic depression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in protein localization to synapse	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of filopodium assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic stress granule	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendritic shaft	IEA Inferred from Electronic Annotation more info
located_in dendritic shaft	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: double-stranded RNA-binding protein Staufen homolog 2

Names: staufen (RNA binding protein) homolog 2; staufen 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001111272.1 → NP_001104742.1 double-stranded RNA-binding protein Staufen homolog 2 isoform 2

See identical proteins and their annotated locations for NP_001104742.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate segment in the 5' end, compared to variant 1. This difference causes translation initiation at an upstream AUG and a protein (isoform 2) with a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AK031102, BI987531, BY290411, CN665159

Consensus CDS

CCDS48223.1

UniProtKB/TrEMBL

E2QRQ3

Related

ENSMUSP00000027052.7, ENSMUST00000027052.13

Conserved Domains (5) summary

pfam16482
Location:433 → 491

Staufen_C; Staufen C-terminal domain

cd19882
Location:66 → 147

DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19884
Location:174 → 240

DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19886
Location:272 → 357

DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cl00054
Location:6 → 38

DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
NM_001347044.1 → NP_001333973.1 double-stranded RNA-binding protein Staufen homolog 2 isoform 4

Status: VALIDATED

Source sequence(s)

AC115952, AC116695, AC162448

Consensus CDS

CCDS83528.1

UniProtKB/TrEMBL

D3Z6D2, E2QRQ3

Related

ENSMUSP00000122410.3, ENSMUST00000128957.9
NM_001347045.1 → NP_001333974.1 double-stranded RNA-binding protein Staufen homolog 2 isoform 5

Status: VALIDATED

Source sequence(s)

AC115952, AC116695, AC162448

Consensus CDS

CCDS83529.1

UniProtKB/TrEMBL

E2QRQ3

Related

ENSMUSP00000124303.2, ENSMUST00000162007.8

Conserved Domains (5) summary

pfam16482
Location:433 → 479

Staufen_C; Staufen C-terminal domain

cd19882
Location:66 → 147

DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19884
Location:174 → 240

DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19886
Location:272 → 357

DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cl00054
Location:6 → 38

DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
NM_025303.3 → NP_079579.2 double-stranded RNA-binding protein Staufen homolog 2 isoform 3

See identical proteins and their annotated locations for NP_079579.2

Status: VALIDATED

Description

Transcript Variant: This variant (3) has multiple differences in the presence and absence of exons, compared to variant 1. These differences produce a unique 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 3) is shorter than isoform 1.

Source sequence(s)

AC115952, AC116695, AC162448, AC167117

Consensus CDS

CCDS14831.2

UniProtKB/Swiss-Prot

Q8BSY8, Q8CJ66, Q8CJ67, Q8R175, Q91Z19, Q9D5N7

UniProtKB/TrEMBL

E2QRQ3

Related

ENSMUSP00000124505.2, ENSMUST00000162751.8

Conserved Domains (5) summary

pfam16482
Location:465 → 523

Staufen_C; Staufen C-terminal domain

cd19880
Location:3 → 70

DSRM_STAU2_rpt1; first double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19882
Location:98 → 179

DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19884
Location:206 → 272

DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19886
Location:304 → 389

DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

16299027..16591228 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006495532.5 → XP_006495595.1 double-stranded RNA-binding protein Staufen homolog 2 isoform X3

See identical proteins and their annotated locations for XP_006495595.1

UniProtKB/TrEMBL

E2QRQ3

Related

ENSMUSP00000123827.2, ENSMUST00000162435.8

Conserved Domains (5) summary

pfam16482
Location:433 → 491

Staufen_C; Staufen C-terminal domain

cd19882
Location:66 → 147

DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19884
Location:174 → 240

DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19886
Location:272 → 357

DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cl00054
Location:6 → 38

DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
XM_006495528.5 → XP_006495591.1 double-stranded RNA-binding protein Staufen homolog 2 isoform X1

See identical proteins and their annotated locations for XP_006495591.1

UniProtKB/Swiss-Prot

Q8BSY8, Q8CJ66, Q8CJ67, Q8R175, Q91Z19, Q9D5N7

UniProtKB/TrEMBL

E2QRQ3

Conserved Domains (5) summary

pfam16482
Location:465 → 523

Staufen_C; Staufen C-terminal domain

cd19880
Location:3 → 70

DSRM_STAU2_rpt1; first double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19882
Location:98 → 179

DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19884
Location:206 → 272

DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19886
Location:304 → 389

DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
XM_011238390.3 → XP_011236692.1 double-stranded RNA-binding protein Staufen homolog 2 isoform X4

UniProtKB/TrEMBL

E2QRQ3

Conserved Domains (5) summary

pfam16482
Location:465 → 511

Staufen_C; Staufen C-terminal domain

cd19880
Location:3 → 70

DSRM_STAU2_rpt1; first double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19882
Location:98 → 179

DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19884
Location:206 → 272

DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19886
Location:304 → 389

DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
XM_017321109.3 → XP_017176598.1 double-stranded RNA-binding protein Staufen homolog 2 isoform X5

UniProtKB/TrEMBL

E2QRQ3

Conserved Domains (5) summary

pfam16482
Location:433 → 479

Staufen_C; Staufen C-terminal domain

cd19882
Location:66 → 147

DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19884
Location:174 → 240

DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19886
Location:272 → 357

DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cl00054
Location:6 → 38

DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
XM_017321102.3 → XP_017176591.1 double-stranded RNA-binding protein Staufen homolog 2 isoform X1

UniProtKB/Swiss-Prot

Q8BSY8, Q8CJ66, Q8CJ67, Q8R175, Q91Z19, Q9D5N7

UniProtKB/TrEMBL

E2QRQ3

Conserved Domains (5) summary

pfam16482
Location:465 → 523

Staufen_C; Staufen C-terminal domain

cd19880
Location:3 → 70

DSRM_STAU2_rpt1; first double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19882
Location:98 → 179

DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19884
Location:206 → 272

DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19886
Location:304 → 389

DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
XM_011238387.2 → XP_011236689.1 double-stranded RNA-binding protein Staufen homolog 2 isoform X1

See identical proteins and their annotated locations for XP_011236689.1

UniProtKB/Swiss-Prot

Q8BSY8, Q8CJ66, Q8CJ67, Q8R175, Q91Z19, Q9D5N7

UniProtKB/TrEMBL

E2QRQ3

Conserved Domains (5) summary

pfam16482
Location:465 → 523

Staufen_C; Staufen C-terminal domain

cd19880
Location:3 → 70

DSRM_STAU2_rpt1; first double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19882
Location:98 → 179

DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19884
Location:206 → 272

DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19886
Location:304 → 389

DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
XM_036165647.1 → XP_036021540.1 double-stranded RNA-binding protein Staufen homolog 2 isoform X3

UniProtKB/TrEMBL

E2QRQ3

Conserved Domains (5) summary

pfam16482
Location:433 → 491

Staufen_C; Staufen C-terminal domain

cd19882
Location:66 → 147

DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19884
Location:174 → 240

DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19886
Location:272 → 357

DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cl00054
Location:6 → 38

DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
XM_036165648.1 → XP_036021541.1 double-stranded RNA-binding protein Staufen homolog 2 isoform X3

UniProtKB/TrEMBL

E2QRQ3

Conserved Domains (5) summary

pfam16482
Location:433 → 491

Staufen_C; Staufen C-terminal domain

cd19882
Location:66 → 147

DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19884
Location:174 → 240

DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19886
Location:272 → 357

DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cl00054
Location:6 → 38

DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
XM_011238389.3 → XP_011236691.1 double-stranded RNA-binding protein Staufen homolog 2 isoform X3

See identical proteins and their annotated locations for XP_011236691.1

UniProtKB/TrEMBL

E2QRQ3

Conserved Domains (5) summary

pfam16482
Location:433 → 491

Staufen_C; Staufen C-terminal domain

cd19882
Location:66 → 147

DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19884
Location:174 → 240

DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19886
Location:272 → 357

DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cl00054
Location:6 → 38

DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
XM_030254814.2 → XP_030110674.1 double-stranded RNA-binding protein Staufen homolog 2 isoform X1

UniProtKB/Swiss-Prot

Q8BSY8, Q8CJ66, Q8CJ67, Q8R175, Q91Z19, Q9D5N7

UniProtKB/TrEMBL

E2QRQ3

Conserved Domains (5) summary

pfam16482
Location:465 → 523

Staufen_C; Staufen C-terminal domain

cd19880
Location:3 → 70

DSRM_STAU2_rpt1; first double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19882
Location:98 → 179

DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19884
Location:206 → 272

DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19886
Location:304 → 389

DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
XM_011238388.3 → XP_011236690.1 double-stranded RNA-binding protein Staufen homolog 2 isoform X2

UniProtKB/TrEMBL

E2QRQ3

Conserved Domains (5) summary

pfam16482
Location:465 → 512

Staufen_C; Staufen C-terminal domain

cd19880
Location:3 → 70

DSRM_STAU2_rpt1; first double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19882
Location:98 → 179

DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19884
Location:206 → 272

DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19886
Location:304 → 389

DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins