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    Dimt1 DIM1 rRNA methyltransferase and ribosome maturation factor [ Mus musculus (house mouse) ]

    Gene ID: 66254, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dimt1provided by MGI
    Official Full Name
    DIM1 rRNA methyltransferase and ribosome maturation factorprovided by MGI
    Primary source
    MGI:MGI:1913504
    See related
    Ensembl:ENSMUSG00000021692 AllianceGenome:MGI:1913504
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dimt1l; 1500031M22Rik
    Summary
    Predicted to enable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity. Predicted to be involved in positive regulation of rRNA processing; rRNA methylation; and ribosomal small subunit biogenesis. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Is expressed in telencephalon ventricular layer. Orthologous to human DIMT1 (DIM1 rRNA methyltransferase and ribosome maturation factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 7.5), limb E14.5 (RPKM 6.9) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Dimt1 in Genome Data Viewer
    Location:
    13 D2.1; 13 58.06 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (107083637..107097833)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (106947071..106961325)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene Ipo11-lrrc70 readthrough Neighboring gene importin 11 Neighboring gene STARR-seq mESC enhancer starr_35565 Neighboring gene leucine rich repeat containing 70 Neighboring gene STARR-seq mESC enhancer starr_35568 Neighboring gene STARR-seq mESC enhancer starr_35569 Neighboring gene STARR-seq mESC enhancer starr_35570 Neighboring gene predicted gene, 57603 Neighboring gene STARR-positive B cell enhancer ABC_E1165 Neighboring gene STARR-positive B cell enhancer ABC_E7276 Neighboring gene kinesin family member 2A Neighboring gene RIKEN cDNA 3830408C21 gene Neighboring gene STARR-positive B cell enhancer ABC_E11558 Neighboring gene STARR-seq mESC enhancer starr_35572 Neighboring gene STARR-seq mESC enhancer starr_35573 Neighboring gene STARR-positive B cell enhancer ABC_E5414 Neighboring gene predicted gene, 31715

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in positive regulation of rRNA processing  
    involved_in positive regulation of rRNA processing  
    involved_in rRNA methylation  
    involved_in rRNA methylation  
    involved_in rRNA methylation  
    involved_in ribosomal small subunit biogenesis  
    involved_in ribosomal small subunit biogenesis  
    Component Evidence Code Pubs
    located_in cytosol  
    located_in cytosol  
    is_active_in nucleolus  
    located_in nucleolus  
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleoplasm  
    part_of small-subunit processome  
    part_of small-subunit processome  

    General protein information

    Preferred Names
    dimethyladenosine transferase; probable dimethyladenosine transferase
    Names
    18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase
    18S rRNA dimethylase
    DIM1 dimethyladenosine transferase 1 homolog
    DIM1 dimethyladenosine transferase 1-like
    S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase
    probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase
    probable 18S rRNA dimethylase
    probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase
    NP_079723.1
    XP_036013995.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025447.4NP_079723.1  dimethyladenosine transferase

      See identical proteins and their annotated locations for NP_079723.1

      Status: VALIDATED

      Source sequence(s)
      AK011544, AK078186, BF608861
      Consensus CDS
      CCDS26758.1
      UniProtKB/Swiss-Prot
      Q3TTJ5, Q8BVH8, Q9D0D4
      UniProtKB/TrEMBL
      Q3UK38
      Related
      ENSMUSP00000022203.9, ENSMUST00000022203.10
      Conserved Domains (1) summary
      PTZ00338
      Location:27312
      PTZ00338; dimethyladenosine transferase-like protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      107083637..107097833
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158102.1XP_036013995.1  probable dimethyladenosine transferase isoform X1

      Conserved Domains (1) summary
      cl17173
      Location:1159
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
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