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    Abcb9 ATP-binding cassette, sub-family B member 9 [ Mus musculus (house mouse) ]

    Gene ID: 56325, updated on 9-Dec-2024

    Summary

    Official Symbol
    Abcb9provided by MGI
    Official Full Name
    ATP-binding cassette, sub-family B member 9provided by MGI
    Primary source
    MGI:MGI:1861729
    See related
    Ensembl:ENSMUSG00000029408 AllianceGenome:MGI:1861729
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TAPL; mKIAA1520
    Summary
    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, it may be associated with lysosome activity. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in thymus adult (RPKM 11.0), genital fat pad adult (RPKM 8.2) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Abcb9 in Genome Data Viewer
    Location:
    5 F; 5 63.36 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (124199920..124234009, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (124061857..124095955, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene huntingtin interacting protein 1 related Neighboring gene microRNA 7032 Neighboring gene vacuolar protein sorting 37B Neighboring gene STARR-positive B cell enhancer ABC_E10351 Neighboring gene predicted gene, 34086 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:124525186-124525369 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:124529132-124529326 Neighboring gene STARR-positive B cell enhancer ABC_E432 Neighboring gene predicted gene 16001 Neighboring gene 2-oxoglutarate and iron-dependent oxygenase domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4) 

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ABC-type oligopeptide transporter activity  
    enables ABC-type oligopeptide transporter activity  
    enables ABC-type peptide transporter activity  
    enables ABC-type peptide transporter activity  
    enables ABC-type peptide transporter activity  
    enables ATP binding  
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables transmembrane transporter activity  
    Process Evidence Code Pubs
    involved_in oligopeptide transmembrane transport  
    involved_in peptide metabolic process  
    involved_in peptide metabolic process  
    involved_in peptide transport  
    involved_in peptide transport  
    involved_in protein transport  
    involved_in transmembrane transport  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane PubMed 
    located_in intracellular membrane-bounded organelle  
    located_in lysosomal membrane  
    located_in lysosomal membrane  
    located_in lysosome PubMed 
    located_in lysosome  
    is_active_in membrane  
    located_in membrane  

    General protein information

    Preferred Names
    ABC-type oligopeptide transporter ABCB9
    Names
    ABC transporter 9 protein
    ATP-binding cassette transporter 9
    ATP-binding cassette, sub-family B (MDR/TAP), member 9
    TAP-like protein
    mABCB9
    NP_063928.2
    XP_017176501.1
    XP_036021222.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019875.2NP_063928.2  ABC-type oligopeptide transporter ABCB9

      See identical proteins and their annotated locations for NP_063928.2

      Status: VALIDATED

      Source sequence(s)
      AC113474, AK044140
      Consensus CDS
      CCDS19671.1
      UniProtKB/Swiss-Prot
      Q8CHA1, Q9D212, Q9JIN1, Q9JJ59
      Related
      ENSMUSP00000031354.5, ENSMUST00000031354.11
      Conserved Domains (3) summary
      cd03248
      Location:489714
      ABCC_TAP; ATP-binding cassette domain of the Transporter Associated with Antigen Processing, subfamily C
      TIGR00958
      Location:44734
      3a01208; Conjugate Transporter-2 (CT2) Family protein
      pfam00664
      Location:189451
      ABC_membrane; ABC transporter transmembrane region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      124199920..124234009 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165329.1XP_036021222.1  ABC-type oligopeptide transporter ABCB9 isoform X2

      Conserved Domains (1) summary
      TIGR00958
      Location:2444
      3a01208; Conjugate Transporter-2 (CT2) Family protein
    2. XM_017321012.1XP_017176501.1  ABC-type oligopeptide transporter ABCB9 isoform X1

      Conserved Domains (1) summary
      TIGR00958
      Location:2517
      3a01208; Conjugate Transporter-2 (CT2) Family protein

    RNA

    1. XR_001784728.3 RNA Sequence

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