Kif3c kinesin family member 3C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kif3cprovided by MGI
Official Full Name: kinesin family member 3Cprovided by MGI
Primary source: MGI:MGI:107979
See related: Ensembl:ENSMUSG00000020668 AllianceGenome:MGI:107979
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA4058
Summary: Predicted to enable ATP hydrolysis activity; cytoskeletal protein binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement and positive regulation of neuron projection development. Predicted to be located in several cellular components, including microtubule plus-end; neuronal ribonucleoprotein granule; and synaptic vesicle. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; nervous system; and sensory organ. Orthologous to human KIF3C (kinesin family member 3C). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E18 (RPKM 27.1), whole brain E14.5 (RPKM 23.3) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A1.1; 12 1.77 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (3415132..3456494)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (3365132..3406494)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KIF3A accelerates KIF3C within the kinesin-2 heterodimer to generate symmetrical phosphate release rates for each processive step.
Title: KIF3A accelerates KIF3C within the kinesin-2 heterodimer to generate symmetrical phosphate release rates for each processive step.
The mechanochemistry of the kinesin-2 KIF3AC heterodimer is related to strain-dependent kinetic properties of KIF3A and KIF3C.
Title: The mechanochemistry of the kinesin-2 KIF3AC heterodimer is related to strain-dependent kinetic properties of KIF3A and KIF3C.
Results reveal that engineered homodimeric KIF3CC is targeted to the microtubule plus-end, acts as a potent catastrophe factor through an increase in microtubule catastrophe frequency, and does so by elimination of the dependence of the catastrophe rate on microtubule lifetime. Moreover, KIF3CC accelerates the catastrophe rate without altering the microtubule growth rate.
Title: Homodimeric Kinesin-2 KIF3CC Promotes Microtubule Dynamics.
Study found that both KIF3AC and KIF3AB can traverse long distances over the microtubule track, revealing that these motors are adept and well-tuned for their specialized roles as cargo transporters
Title: Kinesin-2 KIF3AC and KIF3AB Can Drive Long-Range Transport along Microtubules.
Data suggest biocatalysis by Kif3a homodimer, Kif3c homodimer, or Kif3a/Kif3c heterodimer vary; microtubule interaction is very fast for Kif3a homodimer; Kif3c homodimer interaction is much slower; Kif3a/Kif3c heterodimer interaction is intermediate.
Title: Fast or Slow, Either Head Can Start the Processive Run of Kinesin-2 KIF3AC.
KIF3C is an injury-specific kinesin that contributes to axon growth and regeneration by regulating and organizing the microtubule cytoskeleton in the growth cone.
Title: The kinesin-2 family member KIF3C regulates microtubule dynamics and is required for axon growth and regeneration.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF390948 (e-PCR)
- UniSTS:249615

Kif3c (e-PCR), detects polymorphism
- UniSTS:143693

BB448835 (e-PCR)
- UniSTS:208768

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables kinesin binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info	PubMed
located_in microtubule plus-end	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info	PubMed
located_in neuronal ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info	PubMed
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kinesin-like protein KIF3C

Names: N-4 kinesin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008445.2 → NP_032471.2 kinesin-like protein KIF3C

See identical proteins and their annotated locations for NP_032471.2

Status: VALIDATED

Source sequence(s)

AK147572, AK220283, AW125727, BC062648, BQ175623

Consensus CDS

CCDS25783.1

UniProtKB/Swiss-Prot

O35066, O35229, Q3UH55

UniProtKB/TrEMBL

Q571A6

Related

ENSMUSP00000020999.6, ENSMUST00000020999.7

Conserved Domains (4) summary

cd01371
Location:9 → 367

KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins

pfam00225
Location:16 → 367

Kinesin; Kinesin motor domain

cd16269
Location:540 → 551

GBP_C; coiled coil [structural motif]

cl20817
Location:463 → 571

GBP_C; Guanylate-binding protein, C-terminal domain