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    Ndn necdin, MAGE family member [ Mus musculus (house mouse) ]

    Gene ID: 17984, updated on 10-Dec-2024

    Summary

    Official Symbol
    Ndnprovided by MGI
    Official Full Name
    necdin, MAGE family memberprovided by MGI
    Primary source
    MGI:MGI:97290
    See related
    Ensembl:ENSMUSG00000033585 AllianceGenome:MGI:97290
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Peg6
    Summary
    Enables gamma-tubulin binding activity and promoter-specific chromatin binding activity. Acts upstream of or within several processes, including nervous system development; neurotrophin TRK receptor signaling pathway; and regulation of DNA-templated transcription. Located in several cellular components, including centrosome; cytosol; and nucleus. Part of protein-containing complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Used to study Prader-Willi syndrome. Human ortholog(s) of this gene implicated in Prader-Willi syndrome. Orthologous to human NDN (necdin, MAGE family member). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Ndn in Genome Data Viewer
    Location:
    7 34.36 cM; 7 C
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (61998025..61999676)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (62348277..62349928)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53390 Neighboring gene microRNA 344i Neighboring gene predicted gene, 42395 Neighboring gene predicted gene, 32061 Neighboring gene MAGE family member L2 Neighboring gene makorin, ring finger protein, 3

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding  
    enables gamma-tubulin binding PubMed 
    enables promoter-specific chromatin binding PubMed 
    enables protein binding PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within axon extension PubMed 
    acts_upstream_of_or_within axonal fasciculation PubMed 
    acts_upstream_of_or_within axonogenesis PubMed 
    acts_upstream_of_or_within central nervous system development PubMed 
    acts_upstream_of_or_within genomic imprinting PubMed 
    acts_upstream_of_or_within glial cell migration PubMed 
    acts_upstream_of_or_within multicellular organismal-level homeostasis PubMed 
    acts_upstream_of_or_within negative regulation of DNA-binding transcription factor activity PubMed 
    acts_upstream_of_or_within negative regulation of DNA-binding transcription factor activity PubMed 
    involved_in negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within neuron development PubMed 
    acts_upstream_of_or_within neuron differentiation PubMed 
    acts_upstream_of_or_within neuron migration PubMed 
    acts_upstream_of_or_within neurotrophin TRK receptor signaling pathway PubMed 
    acts_upstream_of_or_within positive regulation of protein deacetylation PubMed 
    acts_upstream_of_or_within positive regulation of protein deacetylation PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within post-embryonic development PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription PubMed 
    acts_upstream_of_or_within respiratory gaseous exchange by respiratory system PubMed 
    acts_upstream_of_or_within respiratory system process PubMed 
    acts_upstream_of_or_within sensory perception of pain PubMed 
    Component Evidence Code Pubs
    located_in cell projection PubMed 
    located_in centrosome PubMed 
    located_in cytoplasm PubMed 
    located_in cytosol PubMed 
    located_in cytosol  
    located_in nuclear matrix  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    part_of protein-containing complex PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010882.3NP_035012.2  necdin

      See identical proteins and their annotated locations for NP_035012.2

      Status: VALIDATED

      Source sequence(s)
      AK135444, AU080413, BY669518
      Consensus CDS
      CCDS21326.1
      UniProtKB/Swiss-Prot
      B9EJJ5, P25233, Q542W7, Q61951
      UniProtKB/TrEMBL
      Q8C5K8
      Related
      ENSMUSP00000045369.5, ENSMUST00000038775.6
      Conserved Domains (1) summary
      pfam01454
      Location:109277
      MAGE; MAGE family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      61998025..61999676
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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