Vim vimentin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vimprovided by MGI
Official Full Name: vimentinprovided by MGI
Primary source: MGI:MGI:98932
See related: Ensembl:ENSMUSG00000026728 AllianceGenome:MGI:98932
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables RNA binding activity. A structural constituent of cytoskeleton and structural constituent of eye lens. Involved in intermediate filament organization and positive regulation of gene expression. Acts upstream of or within several processes, including astrocyte differentiation; cellular response to type II interferon; and lens fiber cell development. Located in several cellular components, including cell leading edge; intermediate filament; and phagocytic vesicle. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Used to study cataract 30. Human ortholog(s) of this gene implicated in atherosclerosis; autoimmune disease (multiple); and cataract 30. Orthologous to human VIM (vimentin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in subcutaneous fat pad adult (RPKM 622.6), mammary gland adult (RPKM 524.7) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A1; 2 10.04 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (13579122..13587637)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (13574311..13582826)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Vimentin supports cell polarization by enhancing centrosome function and microtubule acetylation.
Title: Vimentin supports cell polarization by enhancing centrosome function and microtubule acetylation.
Vimentin takes a hike - Emerging roles of extracellular vimentin in cancer and wound healing.
Title: Vimentin takes a hike - Emerging roles of extracellular vimentin in cancer and wound healing.
Co-expression of galectin-3 and vimentin in triple negative breast cancer cells promotes tumor progression, metastasis and survival.
Title: Co-expression of galectin-3 and vimentin in triple negative breast cancer cells promotes tumor progression, metastasis and survival.
Vimentin is required for tumor progression and metastasis in a mouse model of non-small cell lung cancer.
Title: Vimentin is required for tumor progression and metastasis in a mouse model of non-small cell lung cancer.
Roles of vimentin in health and disease.
Title: Roles of vimentin in health and disease.
Vimentin Inhibits Dengue Virus Type 2 Invasion of the Blood-Brain Barrier.
Title: Vimentin Inhibits Dengue Virus Type 2 Invasion of the Blood-Brain Barrier.
Vimentin Intermediate Filaments Mediate Cell Morphology on Viscoelastic Substrates.
Title: Vimentin Intermediate Filaments Mediate Cell Morphology on Viscoelastic Substrates.
RNAi-mediated suppression of vimentin or glial fibrillary acidic protein prevents the establishment of Muller glial cell hypertrophy in progressive retinal degeneration.
Title: RNAi-mediated suppression of vimentin or glial fibrillary acidic protein prevents the establishment of Müller glial cell hypertrophy in progressive retinal degeneration.
Rapid tumor recurrence in a novel murine GBM surgical model is associated with Akt/PD-L1/vimentin signaling.
Title: Rapid tumor recurrence in a novel murine GBM surgical model is associated with Akt/PD-L1/vimentin signaling.
Vimentin Association with Nuclear Grooves in Normal MEF 3T3 Cells.
Title: Vimentin Association with Nuclear Grooves in Normal MEF 3T3 Cells.

Submit: New GeneRIF Correction See all GeneRIFs (103)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8) 1 citation
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Vim (e-PCR), detects polymorphism
- UniSTS:547844

VIM (e-PCR)
- UniSTS:253717

Vim (e-PCR), detects polymorphism
- UniSTS:461982

VIM (e-PCR)
- UniSTS:527007

Vim (e-PCR), detects polymorphism
- UniSTS:527007

Vim (e-PCR), detects polymorphism
- UniSTS:507308

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables keratin filament binding	IEA Inferred from Electronic Annotation more info
enables keratin filament binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 2A binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed
enables structural constituent of cytoskeleton	ISO Inferred from Sequence Orthology more info
enables structural constituent of eye lens	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Bergmann glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within astrocyte development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to muramyl dipeptide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to muramyl dipeptide	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intermediate filament organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intermediate filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intermediate filament-based process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lens fiber cell development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of neuron projection development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of neuron projection development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of collagen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of Schwann cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA stability	IEA Inferred from Electronic Annotation more info
involved_in regulation of mRNA stability	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in intermediate filament	IBA Inferred from Biological aspect of Ancestor more info
located_in intermediate filament	IDA Inferred from Direct Assay more info	PubMed
located_in intermediate filament	ISO Inferred from Sequence Orthology more info
located_in intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear matrix	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in type III intermediate filament	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: vimentin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.