Tiam1 T cell lymphoma invasion and metastasis 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tiam1provided by MGI
Official Full Name: T cell lymphoma invasion and metastasis 1provided by MGI
Primary source: MGI:MGI:103306
See related: Ensembl:ENSMUSG00000002489 AllianceGenome:MGI:103306
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D16Ium10; D16Ium10e
Summary: Enables several functions, including guanyl-nucleotide exchange factor activity; microtubule binding activity; and signaling receptor binding activity. Involved in several processes, including activation of GTPase activity; brain-derived neurotrophic factor receptor signaling pathway; and regulation of dopaminergic neuron differentiation. Acts upstream of or within ephrin receptor signaling pathway; positive regulation of axonogenesis; and small GTPase-mediated signal transduction. Located in kinocilium; pericentriolar material; and plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; sensory organ; skin; and tooth. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with language delay and seizures. Orthologous to human TIAM1 (TIAM Rac1 associated GEF 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in cerebellum adult (RPKM 9.6), frontal lobe adult (RPKM 5.9) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C3.3; 16 51.5 cM

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (89583999..89942488, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (89787111..90145600, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

S-Nitrosylation of Septin2 Exacerbates Aortic Aneurysm and Dissection by Coupling the TIAM1-RAC1 Axis in Macrophages.
Title: S-Nitrosylation of Septin2 Exacerbates Aortic Aneurysm and Dissection by Coupling the TIAM1-RAC1 Axis in Macrophages.
Decreased Tiam1-mediated Rac1 activation is responsible for impaired directional persistence of chondrocyte migration in microtia.
Title: Decreased Tiam1-mediated Rac1 activation is responsible for impaired directional persistence of chondrocyte migration in microtia.
Tiam1 regulates proliferation, invasion, and differentiation in neuroblastoma through the Tiam1/Rac1 signaling pathway.
Title: Tiam1 regulates proliferation, invasion, and differentiation in neuroblastoma through the Tiam1/Rac1 signaling pathway.
TIAM1-mediated synaptic plasticity underlies comorbid depression-like and ketamine antidepressant-like actions in chronic pain.
Title: TIAM1-mediated synaptic plasticity underlies comorbid depression-like and ketamine antidepressant-like actions in chronic pain.
Opposite functions of STAT3 and Smad3 in regulating Tiam1 expression in Th17 cells.
Title: Opposite functions of STAT3 and Smad3 in regulating Tiam1 expression in Th17 cells.
Tiam1 mediates Rac1 activation and contraction-induced glucose uptake in skeletal muscle cells.
Title: Tiam1 mediates Rac1 activation and contraction-induced glucose uptake in skeletal muscle cells.
The Rac-GEF Tiam1 Promotes Dendrite and Synapse Stabilization of Dentate Granule Cells and Restricts Hippocampal-Dependent Memory Functions.
Title: The Rac-GEF Tiam1 Promotes Dendrite and Synapse Stabilization of Dentate Granule Cells and Restricts Hippocampal-Dependent Memory Functions.
Myoblast Migration and Directional Persistence Affected by Syndecan-4-Mediated Tiam-1 Expression and Distribution.
Title: Myoblast Migration and Directional Persistence Affected by Syndecan-4-Mediated Tiam-1 Expression and Distribution.
we generated a Tiam1 mutant knock-in mouse line in which critical residues for CaMKII binding were mutated into alanines. KI mice showed reduced Rac1 activity, had smaller spines and a diminished sLTP as compared to their wild-type littermates. novel object recognition memory of these animals was impaired. We propose that the CaMKII-Tiam1 interaction regulates spine morphology in vivo and is required for memory storage.
Title: The role of CaMKII-Tiam1 complex on learning and memory.
MiR-190a potentially ameliorates postoperative cognitive dysfunction by regulating Tiam1
Title: MiR-190a potentially ameliorates postoperative cognitive dysfunction by regulating Tiam1.

Submit: New GeneRIF Correction See all GeneRIFs (45)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

TIAM1 (e-PCR)
- UniSTS:506184

Tiam1 (e-PCR), detects polymorphism
- UniSTS:259157

AI847750 (e-PCR)
- UniSTS:166013

D1S3690 (e-PCR)
- UniSTS:474268

U05245 (e-PCR)
- UniSTS:125650

NoName (e-PCR)
- UniSTS:237542

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ephrin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables guanyl-nucleotide exchange factor activity	TAS Traceable Author Statement more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in NMDA selective glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in Rac protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in activation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in brain-derived neurotrophic factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-matrix adhesion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within ephrin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron projection extension	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Schwann cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein binding	ISO Inferred from Sequence Orthology more info
involved_in protein localization to membrane	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of dopaminergic neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in regulation of modification of postsynaptic actin cytoskeleton	ISO Inferred from Sequence Orthology more info
involved_in regulation of non-canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of postsynapse organization	ISO Inferred from Sequence Orthology more info
involved_in small GTPase-mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within small GTPase-mediated signal transduction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in axonal growth cone	ISO Inferred from Sequence Orthology more info
located_in cell-cell contact zone	ISO Inferred from Sequence Orthology more info
located_in cell-cell contact zone	ISS Inferred from Sequence or Structural Similarity more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in extrinsic component of postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in kinocilium	IDA Inferred from Direct Assay more info	PubMed
located_in main axon	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in pericentriolar material	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info
located_in somatodendritic compartment	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: rho guanine nucleotide exchange factor TIAM1

Names: T-lymphoma invasion and metastasis-inducing protein 1; TIAM-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145886.1 → NP_001139358.1 rho guanine nucleotide exchange factor TIAM1 isoform 1

See identical proteins and their annotated locations for NP_001139358.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AK017465, AK136856, AK147392, BC065126, CJ262109, CO042855

Consensus CDS

CCDS28314.1

UniProtKB/Swiss-Prot

Q60610

UniProtKB/TrEMBL

G3UWG2

Related

ENSMUSP00000132137.2, ENSMUST00000163370.8

Conserved Domains (6) summary

smart00455
Location:766 → 832

RBD; Raf-like Ras-binding domain

smart00325
Location:1044 → 1233

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:846 → 925

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1235 → 1406

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam18385
Location:572 → 669

Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
NM_001145887.1 → NP_001139359.1 rho guanine nucleotide exchange factor TIAM1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks many 5' coding exons, and initiates translation at an alternate start codon, compared to variant 1. This results in a shorter isoform (2) with a distinct N-terminus compared to isoform 1.

Source sequence(s)

AK136856, AK147392, BC065126, CJ262109, CO042855

Consensus CDS

CCDS49904.1

UniProtKB/TrEMBL

E9Q1R7, Q3UVX2

Related

ENSMUSP00000126020.3, ENSMUST00000164263.9

Conserved Domains (3) summary

smart00325
Location:75 → 264

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd01255
Location:266 → 437

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam00169
Location:314 → 426

PH; PH domain
NM_001426931.1 → NP_001413860.1 rho guanine nucleotide exchange factor TIAM1 isoform 1

Status: VALIDATED

Source sequence(s)

AC087840, AC102908, AC122218

UniProtKB/Swiss-Prot

Q60610

UniProtKB/TrEMBL

G3UWG2
NM_001426932.1 → NP_001413861.1 rho guanine nucleotide exchange factor TIAM1 isoform 1

Status: VALIDATED

Source sequence(s)

AC087840, AC102908, AC122218, AC132099

UniProtKB/Swiss-Prot

Q60610

UniProtKB/TrEMBL

G3UWG2
NM_001426933.1 → NP_001413862.1 rho guanine nucleotide exchange factor TIAM1 isoform 1

Status: VALIDATED

Source sequence(s)

AC087840, AC102908, AC122218, AC132099

UniProtKB/Swiss-Prot

Q60610

UniProtKB/TrEMBL

G3UWG2
NM_009384.4 → NP_033410.2 rho guanine nucleotide exchange factor TIAM1 isoform 1

See identical proteins and their annotated locations for NP_033410.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AC087840, AC102908, AC122218

Consensus CDS

CCDS28314.1

UniProtKB/Swiss-Prot

Q60610

UniProtKB/TrEMBL

G3UWG2

Related

ENSMUSP00000002588.4, ENSMUST00000002588.11

Conserved Domains (6) summary

smart00455
Location:766 → 832

RBD; Raf-like Ras-binding domain

smart00325
Location:1044 → 1233

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:846 → 925

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1235 → 1406

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam18385
Location:572 → 669

Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

89583999..89942488 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017316936.2 → XP_017172425.1 rho guanine nucleotide exchange factor TIAM1 isoform X1

UniProtKB/Swiss-Prot

Q60610

UniProtKB/TrEMBL

G3UWG2

Conserved Domains (6) summary

smart00455
Location:766 → 832

RBD; Raf-like Ras-binding domain

smart00325
Location:1044 → 1233

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:846 → 925

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1235 → 1406

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam18385
Location:572 → 669

Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
XM_030249040.2 → XP_030104900.1 rho guanine nucleotide exchange factor TIAM1 isoform X1

UniProtKB/Swiss-Prot

Q60610

UniProtKB/TrEMBL

G3UWG2

Conserved Domains (6) summary

smart00455
Location:766 → 832

RBD; Raf-like Ras-binding domain

smart00325
Location:1044 → 1233

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:846 → 925

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1235 → 1406

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam18385
Location:572 → 669

Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
XM_030249041.2 → XP_030104901.1 rho guanine nucleotide exchange factor TIAM1 isoform X1

UniProtKB/Swiss-Prot

Q60610

UniProtKB/TrEMBL

G3UWG2

Conserved Domains (6) summary

smart00455
Location:766 → 832

RBD; Raf-like Ras-binding domain

smart00325
Location:1044 → 1233

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:846 → 925

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1235 → 1406

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam18385
Location:572 → 669

Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
XM_036159872.1 → XP_036015765.1 rho guanine nucleotide exchange factor TIAM1 isoform X1

UniProtKB/Swiss-Prot

Q60610

UniProtKB/TrEMBL

G3UWG2

Conserved Domains (6) summary

smart00455
Location:766 → 832

RBD; Raf-like Ras-binding domain

smart00325
Location:1044 → 1233

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:846 → 925

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1235 → 1406

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam18385
Location:572 → 669

Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
XM_006522982.5 → XP_006523045.1 rho guanine nucleotide exchange factor TIAM1 isoform X1

See identical proteins and their annotated locations for XP_006523045.1

UniProtKB/Swiss-Prot

Q60610

UniProtKB/TrEMBL

G3UWG2

Conserved Domains (6) summary

smart00455
Location:766 → 832

RBD; Raf-like Ras-binding domain

smart00325
Location:1044 → 1233

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:846 → 925

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1235 → 1406

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam18385
Location:572 → 669

Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
XM_006522983.5 → XP_006523046.1 rho guanine nucleotide exchange factor TIAM1 isoform X2

UniProtKB/TrEMBL

Q3UHH6

Conserved Domains (6) summary

smart00325
Location:751 → 940

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:553 → 632

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:139 → 265

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:942 → 1113

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam02196
Location:473 → 542

RBD; Raf-like Ras-binding domain

pfam18385
Location:279 → 376

Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain