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    Kcnq1ot1 KCNQ1 overlapping transcript 1 [ Mus musculus (house mouse) ]

    Gene ID: 63830, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kcnq1ot1provided by MGI
    Official Full Name
    KCNQ1 overlapping transcript 1provided by MGI
    Primary source
    MGI:MGI:1926855
    See related
    Ensembl:ENSMUSG00000101609 AllianceGenome:MGI:1926855
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lit1; Tssc8; Kvlqt1-as
    Summary
    The distal end of mouse chromosome 7 contains two clusters of epigenetically-regulated genes that are expressed from only one chromosome in a parent-of-origin manner. Each cluster, or imprinted domain, is regulated by a functionally independent imprinting control region (ICR). The telomeric imprinted domain is regulated by an ICR located in an intron of Kcnq1, and contains at least eight genes that are expressed exclusively or preferentially from the maternally-inherited allele. The DNA of the ICR is specifically methylated on the maternally-inherited chromosome, and unmethylated on the paternally-inherited chromosome. The ICR contains the promoter of the Kcnq1ot1 gene that is exclusively expressed from the paternal allele. The Kcnq1ot1 transcript is the antisense to the Kcnq1 gene and is a unspliced long non-coding RNA. It interacts with chromatin and regulates transcription of multiple target genes through epigenetic modifications. [provided by RefSeq, Mar 2012]
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    Genomic context

    See Kcnq1ot1 in Genome Data Viewer
    Location:
    7 F5; 7 88.15 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (142766848..142850284, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (143213111..143296547, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily M, member 5 Neighboring gene VISTA enhancer mm183 Neighboring gene STARR-seq mESC enhancer starr_20525 Neighboring gene potassium voltage-gated channel, subfamily Q, member 1 Neighboring gene predicted gene 28821 Neighboring gene STARR-positive B cell enhancer ABC_E10485 Neighboring gene RIKEN cDNA 4933417O13 gene Neighboring gene STARR-seq mESC enhancer starr_20528 Neighboring gene STARR-seq mESC enhancer starr_20529 Neighboring gene STARR-seq mESC enhancer starr_20530 Neighboring gene cyclin dependent kinase inhibitor 1C

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    General gene information

    Other Names

    • KCNQ1 antisense RNA 2
    • antisense transcript of Kvlqt1
    • tumor-suppressing subchromosomal transferable fragment 8

    Gene Ontology Provided by MGI

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_001461.6 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC012540
      Related
      ENSMUST00000185789.3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      142766848..142850284 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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