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    Stat4 signal transducer and activator of transcription 4 [ Mus musculus (house mouse) ]

    Gene ID: 20849, updated on 17-Dec-2024

    Summary

    Official Symbol
    Stat4provided by MGI
    Official Full Name
    signal transducer and activator of transcription 4provided by MGI
    Primary source
    MGI:MGI:103062
    See related
    Ensembl:ENSMUSG00000062939 AllianceGenome:MGI:103062
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. Homozygous knockout mice for this gene exhibit reduced inflammation and cytokine production in response to immune challenge. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
    Expression
    Biased expression in testis adult (RPKM 66.2) and spleen adult (RPKM 2.1) See more
    Orthologs
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    Genomic context

    See Stat4 in Genome Data Viewer
    Location:
    1 C1.1; 1 26.67 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (52026265..52146348)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (51987106..52107189)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 8419 Neighboring gene ribosomal protein L15 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr1:52061000-52061301 Neighboring gene STARR-positive B cell enhancer ABC_E2542 Neighboring gene STARR-seq mESC enhancer starr_00894 Neighboring gene ribosomal protein L23A pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10010 Neighboring gene predicted gene, 31812 Neighboring gene STARR-positive B cell enhancer ABC_E3272 Neighboring gene STARR-positive B cell enhancer ABC_E3273 Neighboring gene signal transducer and activator of transcription 1 Neighboring gene transmembrane protein 209 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7722 Neighboring gene glutaminase Neighboring gene STARR-positive B cell enhancer ABC_E1992

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in T-helper 1 cell differentiation  
    involved_in cell surface receptor signaling pathway via JAK-STAT  
    involved_in cytokine-mediated signaling pathway  
    acts_upstream_of_or_within cytokine-mediated signaling pathway PubMed 
    involved_in defense response  
    acts_upstream_of_or_within hematopoietic stem cell homeostasis PubMed 
    involved_in interleukin-12-mediated signaling pathway  
    acts_upstream_of_or_within leukocyte proliferation PubMed 
    acts_upstream_of_or_within positive regulation of gene expression PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within protein phosphorylation PubMed 
    involved_in regulation of cell population proliferation  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in response to interleukin-6  
    involved_in response to peptide hormone  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex  
    part_of RNA polymerase II transcription regulator complex  
    is_active_in cytoplasm  
    located_in cytosol  
    is_active_in nucleus  
    located_in nucleus PubMed 
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    signal transducer and activator of transcription 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308266.1NP_001295195.1  signal transducer and activator of transcription 4

      See identical proteins and their annotated locations for NP_001295195.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK132675, BF020635
      Consensus CDS
      CCDS14943.1
      UniProtKB/Swiss-Prot
      P42228
      UniProtKB/TrEMBL
      Q3V157
      Related
      ENSMUSP00000130713.2, ENSMUST00000168302.8
      Conserved Domains (4) summary
      cd10375
      Location:553700
      SH2_STAT4; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 4proteins
      smart00964
      Location:2121
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:140314
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:316562
      STAT_bind; STAT protein, DNA binding domain
    2. NM_011487.5NP_035617.1  signal transducer and activator of transcription 4

      See identical proteins and their annotated locations for NP_035617.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC108840, AK132675, BF020635, BY097735, BY750146
      Consensus CDS
      CCDS14943.1
      UniProtKB/Swiss-Prot
      P42228
      UniProtKB/TrEMBL
      Q3V157
      Related
      ENSMUSP00000027277.6, ENSMUST00000027277.7
      Conserved Domains (4) summary
      cd10375
      Location:553700
      SH2_STAT4; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 4proteins
      smart00964
      Location:2121
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:140314
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:316562
      STAT_bind; STAT protein, DNA binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      52026265..52146348
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495815.2XP_006495878.1  signal transducer and activator of transcription 4 isoform X1

      UniProtKB/Swiss-Prot
      P42228
      Conserved Domains (4) summary
      cd10375
      Location:573720
      SH2_STAT4; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 4proteins
      cd16854
      Location:160332
      STAT4_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 4 (STAT4)
      cd16848
      Location:336493
      STAT4_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 4 (STAT4)
      cl03749
      Location:64141
      STAT_int; STAT protein, protein interaction domain
    2. XM_006495816.1XP_006495879.1  signal transducer and activator of transcription 4 isoform X2

      UniProtKB/Swiss-Prot
      P42228
      Conserved Domains (4) summary
      cd10375
      Location:502649
      SH2_STAT4; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 4proteins
      cd16854
      Location:89261
      STAT4_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 4 (STAT4)
      cd16848
      Location:265422
      STAT4_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 4 (STAT4)
      cl03749
      Location:1470
      STAT_int; STAT protein, protein interaction domain
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