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    Trim15 tripartite motif-containing 15 [ Mus musculus (house mouse) ]

    Gene ID: 69097, updated on 9-Dec-2024

    Summary

    Official Symbol
    Trim15provided by MGI
    Official Full Name
    tripartite motif-containing 15provided by MGI
    Primary source
    MGI:MGI:1916347
    See related
    Ensembl:ENSMUSG00000050747 AllianceGenome:MGI:1916347
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810012B10Rik
    Summary
    Predicted to enable molecular sequestering activity; transcription coactivator activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including defense response to symbiont; regulation of gene expression; and regulation of intracellular signal transduction. Predicted to be active in cytoplasm and nucleus. Orthologous to human TRIM15 (tripartite motif containing 15). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in large intestine adult (RPKM 14.4), small intestine adult (RPKM 8.1) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Trim15 in Genome Data Viewer
    Location:
    17 B1; 17 19.16 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (37171582..37179066, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (36860690..36867367, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene histocompatibility 2, M region locus 10.6 Neighboring gene STARR-positive B cell enhancer ABC_E612 Neighboring gene tripartite motif-containing 26 Neighboring gene predicted gene, 25973 Neighboring gene tripartite motif-containing 10 Neighboring gene phosphatidylethanolamine binding protein 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular sequestering activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase TRIM15
    Names
    tripartite motif protein 15
    NP_001019305.1
    NP_001171343.1
    XP_036016670.1
    XP_036016671.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024134.2NP_001019305.1  E3 ubiquitin-protein ligase TRIM15 isoform 2

      See identical proteins and their annotated locations for NP_001019305.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an additional segment in the 3' CDS, as compared to variant 1, resulting in a reading frame shift. The resulting isoform (2) is slightly shorter and has a different C-terminus, as compared to isoform 1.
      Source sequence(s)
      CR956641
      Consensus CDS
      CCDS50102.1
      UniProtKB/TrEMBL
      Q8R096
      Related
      ENSMUSP00000025329.7, ENSMUST00000025329.13
      Conserved Domains (3) summary
      cd00021
      Location:76114
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl17238
      Location:1553
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cl21478
      Location:193290
      ATP-synt_B; ATP synthase B/B' CF(0)
    2. NM_001177872.1NP_001171343.1  E3 ubiquitin-protein ligase TRIM15 isoform 1

      See identical proteins and their annotated locations for NP_001171343.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      CR956641
      Consensus CDS
      CCDS57079.1
      UniProtKB/TrEMBL
      G3UY57
      Related
      ENSMUSP00000133953.2, ENSMUST00000174195.8
      Conserved Domains (3) summary
      cd00021
      Location:76114
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl17238
      Location:1553
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cl21478
      Location:193290
      ATP-synt_B; ATP synthase B/B' CF(0)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      37171582..37179066 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160777.1XP_036016670.1  E3 ubiquitin-protein ligase TRIM15 isoform X1

      Conserved Domains (4) summary
      COG1196
      Location:122269
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00162
      Location:1553
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cl00034
      Location:76114
      Bbox_SF; B-box-type zinc finger superfamily
      cl17238
      Location:1554
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    2. XM_036160778.1XP_036016671.1  E3 ubiquitin-protein ligase TRIM15 isoform X2

    RNA

    1. XR_385361.5 RNA Sequence

    2. XR_876527.1 RNA Sequence