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    Naaa N-acylethanolamine acid amidase [ Mus musculus (house mouse) ]

    Gene ID: 67111, updated on 9-Dec-2024

    Summary

    Official Symbol
    Naaaprovided by MGI
    Official Full Name
    N-acylethanolamine acid amidaseprovided by MGI
    Primary source
    MGI:MGI:1914361
    See related
    Ensembl:ENSMUSG00000029413 AllianceGenome:MGI:1914361
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Asahl; 2210023K21Rik; 3830414F09Rik
    Summary
    Predicted to enable DNA-binding transcription factor binding activity and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. Predicted to be involved in several processes, including N-acylethanolamine metabolic process; N-acylphosphatidylethanolamine metabolic process; and sphingosine metabolic process. Located in lysosome. Is expressed in future brain and ventricular layer. Orthologous to human NAAA (N-acylethanolamine acid amidase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in mammary gland adult (RPKM 35.5), lung adult (RPKM 32.3) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Naaa in Genome Data Viewer
    Location:
    5 E2; 5 46.35 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (92405519..92426040, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (92257660..92278181, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42112 Neighboring gene protein phosphatase, EF hand calcium-binding domain 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:92674514-92674783 Neighboring gene STARR-positive B cell enhancer ABC_E10329 Neighboring gene STARR-positive B cell enhancer ABC_E2750 Neighboring gene SDA1 domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_13638 Neighboring gene predicted gene, 23031 Neighboring gene C-X-C motif chemokine ligand 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in N-acylethanolamine metabolic process  
    involved_in N-acylethanolamine metabolic process  
    involved_in N-acylphosphatidylethanolamine metabolic process  
    involved_in N-acylphosphatidylethanolamine metabolic process  
    involved_in fatty acid metabolic process  
    involved_in fatty acid metabolic process  
    involved_in fatty acid metabolic process  
    involved_in lipid catabolic process  
    involved_in sphingosine metabolic process  
    involved_in sphingosine metabolic process  
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in lysosome PubMed 
    located_in lysosome  
    located_in lysosome  
    located_in membrane  
    located_in membrane  

    General protein information

    Preferred Names
    N-acylethanolamine-hydrolyzing acid amidase
    Names
    ASAH-like protein
    acylsphingosine deacylase NAAA
    NP_001157159.1
    NP_080248.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163687.1NP_001157159.1  N-acylethanolamine-hydrolyzing acid amidase isoform 2 precursor

      See identical proteins and their annotated locations for NP_001157159.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      AC125542, AK008776, AK017141, AK133485
      Consensus CDS
      CCDS51545.1
      UniProtKB/TrEMBL
      G3XA18, Q3V023
      Related
      ENSMUSP00000124582.2, ENSMUST00000159345.8
      Conserved Domains (2) summary
      cd01903
      Location:120349
      Ntn_AC_NAAA; AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and ...
      pfam15508
      Location:36124
      NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase
    2. NM_025972.4NP_080248.2  N-acylethanolamine-hydrolyzing acid amidase isoform 1 precursor

      See identical proteins and their annotated locations for NP_080248.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AB162194, AC125542, AK008776, AK133485
      Consensus CDS
      CCDS19428.1
      UniProtKB/Swiss-Prot
      Q5KTC6, Q99KM3, Q9D6B4, Q9D7V9
      UniProtKB/TrEMBL
      Q3V023
      Related
      ENSMUSP00000108726.4, ENSMUST00000113102.10
      Conserved Domains (2) summary
      cd01903
      Location:122351
      Ntn_AC_NAAA; AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and ...
      pfam15508
      Location:36126
      NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      92405519..92426040 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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