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    Slc7a15 solute carrier family 7 (cationic amino acid transporter, y+ system), member 15 [ Mus musculus (house mouse) ]

    Gene ID: 328059, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc7a15provided by MGI
    Official Full Name
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 15provided by MGI
    Primary source
    MGI:MGI:3045351
    See related
    Ensembl:ENSMUSG00000020600 AllianceGenome:MGI:3045351
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Arpat
    Summary
    Enables amino acid transmembrane transporter activity. Acts upstream of or within amino acid transport. Part of protein-containing complex. Orthologous to human SLC7A15P (solute carrier family 7 member 15, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in small intestine adult (RPKM 25.2), duodenum adult (RPKM 22.5) and 3 other tissues See more
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    Genomic context

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    See Slc7a15 in Genome Data Viewer
    Location:
    12 A1.1; 12 3.89 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (8578481..8649066, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (8528481..8599066, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31505 Neighboring gene RIKEN cDNA 5033421B08 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:8528304-8528487 Neighboring gene ras homolog family member B Neighboring gene predicted gene, 57593 Neighboring gene STARR-seq mESC enhancer starr_31510 Neighboring gene STARR-positive B cell enhancer ABC_E3048 Neighboring gene STARR-seq mESC enhancer starr_31512 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:8680787-8680896 Neighboring gene STARR-seq mESC enhancer starr_31513 Neighboring gene pumilio RNA-binding family member 2 Neighboring gene predicted gene 4755

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and functional characterization of a novel low affinity aromatic-preferring amino acid transporter (arpAT). One of the few proteins silenced during primate evolution. Fernández E, et al. J Biol Chem, 2005 May 13. PMID 15757906
    2. Changes to gut amino acid transporters and microbiome associated with increased E/I ratio in Chd8(+/-) mouse model of ASD-like behavior. Yu Y, et al. Nat Commun, 2022 Mar 3. PMID 35241668, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. characterization of arpAT (affinity aromatic-preferring amino acid transporter)
      Title: Identification and functional characterization of a novel low affinity aromatic-preferring amino acid transporter (arpAT). One of the few proteins silenced during primate evolution.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • 2010001P20Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within amino acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aromatic-preferring amino acid transporter

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038660.2 → NP_001033749.1  aromatic-preferring amino acid transporter isoform 1

      See identical proteins and their annotated locations for NP_001033749.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC117236, AC166361, AK008024, AK033481
      Consensus CDS
      CCDS25800.1
      UniProtKB/TrEMBL
      Q50E62
      Related
      ENSMUSP00000093548.4, ENSMUST00000095863.10
      Conserved Domains (1) summary
      TIGR00911
      Location:5 → 481
      2A0308; L-type amino acid transporter

    2. NM_001286385.1 → NP_001273314.1  aromatic-preferring amino acid transporter isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC117236, AK008024
      UniProtKB/TrEMBL
      Q9D8H4
      Related
      ENSMUST00000129465.2
      Conserved Domains (1) summary
      TIGR00911
      Location:5 → 252
      2A0308; L-type amino acid transporter

    3. NM_177802.3 → NP_808470.1  aromatic-preferring amino acid transporter isoform 2

      See identical proteins and their annotated locations for NP_808470.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks part of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC117236, AC166361, AK033481
      Consensus CDS
      CCDS25801.1
      UniProtKB/TrEMBL
      Q8BZV2
      Related
      ENSMUSP00000047873.3, ENSMUST00000036938.9
      Conserved Domains (1) summary
      TIGR00911
      Location:2 → 221
      2A0308; L-type amino acid transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      8578481..8649066 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243876.3 → XP_011242178.1  aromatic-preferring amino acid transporter isoform X1

      Conserved Domains (1) summary
      TIGR00911
      Location:5 → 453
      2A0308; L-type amino acid transporter

    2. XM_006515119.4 → XP_006515182.1  aromatic-preferring amino acid transporter isoform X4

      See identical proteins and their annotated locations for XP_006515182.1

      UniProtKB/TrEMBL
      Q8BZV2
      Related
      ENSMUSP00000129806.2, ENSMUST00000165657.3
      Conserved Domains (1) summary
      TIGR00911
      Location:2 → 221
      2A0308; L-type amino acid transporter

    3. XM_006515118.5 → XP_006515181.1  aromatic-preferring amino acid transporter isoform X3

      Conserved Domains (1) summary
      TIGR00911
      Location:5 → 252
      2A0308; L-type amino acid transporter

    4. XM_011243877.3 → XP_011242179.1  aromatic-preferring amino acid transporter isoform X2

      Conserved Domains (1) summary
      TIGR00911
      Location:5 → 382
      2A0308; L-type amino acid transporter
    Nucleotide Protein Strain
    Heading Accession and Version

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