Fignl1 fidgetin-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fignl1provided by MGI
Official Full Name: fidgetin-like 1provided by MGI
Primary source: MGI:MGI:1890648
See related: Ensembl:ENSMUSG00000035455 AllianceGenome:MGI:1890648
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable ATP hydrolysis activity; magnesium ion binding activity; and microtubule severing ATPase activity. Involved in several processes, including male meiotic nuclear division; osteoblast differentiation; and osteoblast proliferation. Acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway. Located in nucleus and perinuclear region of cytoplasm. Is expressed in brain ventricular layer and inferior colliculus. Human ortholog(s) of this gene implicated in nicotine dependence. Orthologous to human FIGNL1 (fidgetin like 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver E14 (RPKM 22.0), liver E14.5 (RPKM 18.3) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A1; 11 7.08 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (11737429..11758962, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (11800288..11808983, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic DNA replication and meiotic recombination.
Title: FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic DNA replication and meiotic recombination.
The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restart.
Title: The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restart.
Microtubule-severing protein Fidgetin-like 1 promotes spindle organization during meiosis of mouse oocytes.
Title: Microtubule-severing protein Fidgetin-like 1 promotes spindle organization during meiosis of mouse oocytes.
Fignl1 as a novel actor in mammal's male meiosis dynamics
Title: Fidgetin-like1 is a strong candidate for a dynamic impairment of male meiosis leading to reduced testis weight in mice.
FIGNL1, a subfamily member of the AAA family of proteins, might play some regulatory role in osteoblast proliferation and differentiation.
Title: Fidgetin-like 1 gene inhibited by basic fibroblast growth factor regulates the proliferation and differentiation of osteoblasts.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables microtubule severing ATPase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ATP metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to ionizing radiation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to ionizing radiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in male meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in osteoblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in regulation of double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear chromosome	ISO Inferred from Sequence Orthology more info
located_in nuclear chromosome	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: fidgetin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163359.2 → NP_001156831.1 fidgetin-like protein 1 isoform 1

See identical proteins and their annotated locations for NP_001156831.1

Status: VALIDATED

Source sequence(s)

AL596450

Consensus CDS

CCDS24438.1

UniProtKB/Swiss-Prot

Q3UF48, Q8BPY9, Q8C2I6, Q9ERZ5

Related

ENSMUSP00000126340.2, ENSMUST00000171938.2

Conserved Domains (3) summary

pfam09336
Location:640 → 680

Vps4_C; Vps4 C terminal oligomerization domain

pfam17862
Location:599 → 630

AAA_lid_3; AAA+ lid domain

cd19525
Location:389 → 574

RecA-like_Figl-1; ATPase domain of Fidgetin-Like 1 (FIGL-1)
NM_001163360.1 → NP_001156832.1 fidgetin-like protein 1

See identical proteins and their annotated locations for NP_001156832.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.

Source sequence(s)

AK051874, AK143850, BY231020, CN693395

Consensus CDS

CCDS24438.1

UniProtKB/Swiss-Prot

Q3UF48, Q8BPY9, Q8C2I6, Q9ERZ5

Related

ENSMUSP00000127489.2, ENSMUST00000171080.8

Conserved Domains (3) summary

pfam09336
Location:640 → 680

Vps4_C; Vps4 C terminal oligomerization domain

pfam17862
Location:599 → 630

AAA_lid_3; AAA+ lid domain

cd19525
Location:389 → 574

RecA-like_Figl-1; ATPase domain of Fidgetin-Like 1 (FIGL-1)
NM_001425651.1 → NP_001412580.1 fidgetin-like protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AL596450
NM_001425652.1 → NP_001412581.1 fidgetin-like protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AL596450
NM_001425653.1 → NP_001412582.1 fidgetin-like protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

AL596450

UniProtKB/Swiss-Prot

Q3UF48, Q8BPY9, Q8C2I6, Q9ERZ5
NM_001425654.1 → NP_001412583.1 fidgetin-like protein 1 isoform 3

Status: VALIDATED

Source sequence(s)

AL596450
NM_001425655.1 → NP_001412584.1 fidgetin-like protein 1 isoform 3

Status: VALIDATED

Source sequence(s)

AL596450
NM_001425656.1 → NP_001412585.1 fidgetin-like protein 1 isoform 3

Status: VALIDATED

Source sequence(s)

AL596450
NM_001425657.1 → NP_001412586.1 fidgetin-like protein 1 isoform 4

Status: VALIDATED

Source sequence(s)

AL596450
NM_001425658.1 → NP_001412587.1 fidgetin-like protein 1 isoform 5

Status: VALIDATED

Source sequence(s)

AL596450
NM_001425659.1 → NP_001412588.1 fidgetin-like protein 1 isoform 6

Status: VALIDATED

Source sequence(s)

AL596450

Related

ENSMUST00000152345.8
NM_021891.4 → NP_068691.2 fidgetin-like protein 1 isoform 1

See identical proteins and their annotated locations for NP_068691.2

Status: VALIDATED

Source sequence(s)

AL596450

Consensus CDS

CCDS24438.1

UniProtKB/Swiss-Prot

Q3UF48, Q8BPY9, Q8C2I6, Q9ERZ5

Related

ENSMUSP00000036932.5, ENSMUST00000047689.11

Conserved Domains (3) summary

pfam09336
Location:640 → 680

Vps4_C; Vps4 C terminal oligomerization domain

pfam17862
Location:599 → 630

AAA_lid_3; AAA+ lid domain

cd19525
Location:389 → 574

RecA-like_Figl-1; ATPase domain of Fidgetin-Like 1 (FIGL-1)

RNA

NR_189574.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL596450

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

11737429..11758962 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156888.1 → XP_036012781.1 fidgetin-like protein 1 isoform X2

UniProtKB/Swiss-Prot

Q3UF48, Q8BPY9, Q8C2I6, Q9ERZ5

Conserved Domains (3) summary

pfam09336
Location:640 → 680

Vps4_C; Vps4 C terminal oligomerization domain

pfam17862
Location:599 → 630

AAA_lid_3; AAA+ lid domain

cd19525
Location:389 → 574

RecA-like_Figl-1; ATPase domain of Fidgetin-Like 1 (FIGL-1)
XM_036156887.1 → XP_036012780.1 fidgetin-like protein 1 isoform X1

Conserved Domains (3) summary

pfam09336
Location:649 → 689

Vps4_C; Vps4 C terminal oligomerization domain

pfam17862
Location:608 → 639

AAA_lid_3; AAA+ lid domain

cd19525
Location:398 → 583

RecA-like_Figl-1; ATPase domain of Fidgetin-Like 1 (FIGL-1)