Camk2a calcium/calmodulin-dependent protein kinase II alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Camk2aprovided by MGI
Official Full Name: calcium/calmodulin-dependent protein kinase II alphaprovided by MGI
Primary source: MGI:MGI:88256
See related: Ensembl:ENSMUSG00000024617 AllianceGenome:MGI:88256
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CaMKII; mKIAA0968
Summary: Enables calcium/calmodulin-dependent protein kinase activity; calmodulin binding activity; and glutamate receptor binding activity. Involved in several processes, including peptidyl-threonine autophosphorylation; regulation of endocannabinoid signaling pathway; and regulation of synaptic vesicle docking. Acts upstream of or within several processes, including G1/S transition of mitotic cell cycle; modulation of chemical synaptic transmission; and protein phosphorylation. Located in mitochondrion and postsynaptic density. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including alimentary system; early embryo; eye; genitourinary system; and nervous system. Used to study autism spectrum disorder and bipolar disorder. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 53 and autosomal recessive intellectual developmental disorder 63. Orthologous to human CAMK2A (calcium/calmodulin dependent protein kinase II alpha). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cortex adult (RPKM 365.9) and frontal lobe adult (RPKM 310.4) See more
Orthologs: human all
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Genomic context

Location:: 18 E1; 18 34.41 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (61058704..61121224)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (60925307..60988152)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of mitochondrial Ca[2+] response and CaMKII/ERK activation by LRRK2[R1441G] mutation correlate with impaired depolarization-induced mitophagy.
Title: Loss of mitochondrial Ca(2+) response and CaMKII/ERK activation by LRRK2(R1441G) mutation correlate with impaired depolarization-induced mitophagy.
Rem2 interacts with CaMKII at synapses and restricts long-term potentiation in hippocampus.
Title: Rem2 interacts with CaMKII at synapses and restricts long-term potentiation in hippocampus.
circADAMTS6 via stabilizing CAMK2A is involved in smoking-induced emphysema through driving M2 macrophage polarization.
Title: circADAMTS6 via stabilizing CAMK2A is involved in smoking-induced emphysema through driving M2 macrophage polarization.
TRPC6 regulates necroptosis in myocardial ischemia/reperfusion injury via Ca[2+]/CaMKII signaling pathway.
Title: TRPC6 regulates necroptosis in myocardial ischemia/reperfusion injury via Ca(2+)/CaMKII signaling pathway.
A critical role of Ca[2+]/calmodulin-dependent protein kinase II in coupling between evening and morning circadian oscillators in the suprachiasmatic nucleus.
Title: A critical role of Ca(2+)/calmodulin-dependent protein kinase II in coupling between evening and morning circadian oscillators in the suprachiasmatic nucleus.
TRPM2 and CaMKII Signaling Drives Excessive GABAergic Synaptic Inhibition Following Ischemia.
Title: TRPM2 and CaMKII Signaling Drives Excessive GABAergic Synaptic Inhibition Following Ischemia.
Deletion of CaMKIIalpha disrupts glucose metabolism, glutamate uptake, and synaptic energetics in the cerebral cortex.
Title: Deletion of CaMKIIα disrupts glucose metabolism, glutamate uptake, and synaptic energetics in the cerebral cortex.
Binding of CaMKII to the NMDA receptor is sufficient for long-term potentiation.
Title: Binding of CaMKII to the NMDA receptor is sufficient for long-term potentiation.
A critical role for CaMKII in behavioral timescale synaptic plasticity in hippocampal CA1 pyramidal neurons.
Title: A critical role for CaMKII in behavioral timescale synaptic plasticity in hippocampal CA1 pyramidal neurons.
Decreased nitrosylation of CaMKII causes aging-associated impairments in memory and synaptic plasticity in mice.
Title: Decreased nitrosylation of CaMKII causes aging-associated impairments in memory and synaptic plasticity in mice.

Submit: New GeneRIF Correction See all GeneRIFs (256)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (7) 1 citation
Targeted (11) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Camk2a (e-PCR), detects polymorphism
- UniSTS:141219

RH125135 (e-PCR)
- UniSTS:161957

UniSTS:225275 (e-PCR)
- UniSTS:225275

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activating protein binding	ISO Inferred from Sequence Orthology more info
enables calcium/calmodulin-dependent protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium/calmodulin-dependent protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium/calmodulin-dependent protein kinase activity	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in NMDA selective glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in angiotensin-activated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to interferon-beta	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interferon-beta	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in dendritic spine development	ISS Inferred from Sequence or Structural Similarity more info
involved_in ionotropic glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hydrolase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter receptor transport to plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-threonine autophosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-threonine autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cardiac muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	ISS Inferred from Sequence or Structural Similarity more info
involved_in postsynaptic neurotransmitter receptor diffusion trapping	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein autophosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of endocannabinoid signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of mitochondrial membrane permeability involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neuronal synaptic plasticity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of neuronal synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle docking	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle docking	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to ischemia	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
part_of calcium- and calmodulin-dependent protein kinase complex	ISO Inferred from Sequence Orthology more info
part_of calcium- and calmodulin-dependent protein kinase complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISS Inferred from Sequence or Structural Similarity more info
located_in glutamatergic postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic cytosol	ISO Inferred from Sequence Orthology more info
located_in postsynaptic cytosol	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic cytosol	ISO Inferred from Sequence Orthology more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: calcium/calmodulin-dependent protein kinase type II subunit alpha

Names: CaMK II; alpha-CaMKII; caM kinase II subunit alpha; caMK-II subunit alpha

NP_001273738.1

EC 2.7.11.17

NP_001390238.1

EC 2.7.11.17

NP_001390241.1

EC 2.7.11.17

NP_033922.1

EC 2.7.11.17

NP_803126.1

EC 2.7.11.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001286809.1 → NP_001273738.1 calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a significant portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 2. The resulting isoform (3) is shorter and has a distinct N-terminus, compared to isoform 2.

Source sequence(s)

AK083245, AW490258, BB659027, BC031745, BY713276

Consensus CDS

CCDS70898.1

UniProtKB/TrEMBL

F8WHB5

Related

ENSMUSP00000048325.7, ENSMUST00000039904.7

Conserved Domains (1) summary

pfam08332
Location:57 → 184

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
NM_001403309.1 → NP_001390238.1 calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 4

Status: VALIDATED

Source sequence(s)

AC124431

UniProtKB/TrEMBL

F8WIS9

Related

ENSMUSP00000025519.5, ENSMUST00000025519.11
NM_001403312.1 → NP_001390241.1 calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2

Status: VALIDATED

Source sequence(s)

AC124431
NM_009792.3 → NP_033922.1 calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 1

See identical proteins and their annotated locations for NP_033922.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR, lacks a significant portion of the 5' coding region, initiates translation at an alternate start codon, and has an additional internal exon in the coding region, compared to variant 2. The resulting isoform (1) is shorter and has a distinct N-terminus and an additional internal segment, compared to isoform 2.

Source sequence(s)

AC124431

Consensus CDS

CCDS29277.1

UniProtKB/Swiss-Prot

P11798

Related

ENSMUSP00000110950.3, ENSMUST00000115295.9

Conserved Domains (1) summary

pfam08332
Location:68 → 195

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
NM_177407.4 → NP_803126.1 calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2

See identical proteins and their annotated locations for NP_803126.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) is the longest transcript and encodes the longest isoform (2).

Source sequence(s)

AK083245, AW490258, BC031745

Consensus CDS

CCDS29276.1

UniProtKB/Swiss-Prot

P11798, Q61284, Q6ZWN4

UniProtKB/TrEMBL

Q80TN1

Related

ENSMUSP00000099952.4, ENSMUST00000102888.10

Conserved Domains (2) summary

cd14086
Location:11 → 302

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:346 → 473

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain