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    Zyg11b zyg-ll family member B, cell cycle regulator [ Mus musculus (house mouse) ]

    Gene ID: 414872, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zyg11bprovided by MGI
    Official Full Name
    zyg-ll family member B, cell cycle regulatorprovided by MGI
    Primary source
    MGI:MGI:2685277
    See related
    Ensembl:ENSMUSG00000034636 AllianceGenome:MGI:2685277
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm431; D4Mgi23; mKIAA1730; 1110046I03Rik; 2810482G21Rik
    Summary
    Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and protein quality control for misfolded or incompletely synthesized proteins. Predicted to be part of Cul2-RING ubiquitin ligase complex. Is expressed in cerebral cortex intermediate zone; cerebral cortex subventricular zone; and cortical plate. Orthologous to human ZYG11B (zyg-11 family member B, cell cycle regulator). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 15.5), whole brain E14.5 (RPKM 12.1) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zyg11b in Genome Data Viewer
    Location:
    4 C7; 4 50.35 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (108084947..108158276, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (108227755..108301125, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene enoyl Coenzyme A hydratase domain containing 2 Neighboring gene zyg-11 family member A, cell cycle regulator Neighboring gene STARR-seq mESC enhancer starr_11034 Neighboring gene predicted gene, 54249 Neighboring gene STARR-positive B cell enhancer ABC_E2701 Neighboring gene STARR-seq mESC enhancer starr_11037 Neighboring gene STARR-seq mESC enhancer starr_11038 Neighboring gene STARR-positive B cell enhancer ABC_E11249 Neighboring gene STARR-positive B cell enhancer ABC_E10246 Neighboring gene STARR-positive B cell enhancer ABC_E7979 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:108000774-108000883 Neighboring gene STARR-positive B cell enhancer ABC_E2702 Neighboring gene cytochrome c oxidase assembly factor 7 Neighboring gene predicted gene, 46889 Neighboring gene predicted gene, 54250

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
    3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    4. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ13456

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein quality control for misfolded or incompletely synthesized proteins ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein quality control for misfolded or incompletely synthesized proteins ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul2-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul2-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein zyg-11 homolog B
    Names
    zyg-ll homolog B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033634.4 → NP_001028806.2  protein zyg-11 homolog B isoform 1

      See identical proteins and their annotated locations for NP_001028806.2

      Status: VALIDATED

      Source sequence(s)
      AL627238, BX293563
      Consensus CDS
      CCDS18448.1
      UniProtKB/Swiss-Prot
      B9EID5, Q148T6, Q3TM33, Q3TMB0, Q3TRM3, Q3UFA3, Q3UFS0, Q80TA0
      Related
      ENSMUSP00000043844.7, ENSMUST00000043616.7
      Conserved Domains (3) summary
      cd00020
      Location:493 → 611
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      cd00116
      Location:177 → 299
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:188 → 213
      LRR_AMN1; leucine-rich repeat [structural motif]

    2. NM_001426993.1 → NP_001413922.1  protein zyg-11 homolog B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL627238, BX293563

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      108084947..108158276 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UFS0.2 GenPept UniProtKB/Swiss-Prot:Q3UFS0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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